u/Squintsisgod

In episode #394, PA discusses sleep pharmacology, including drugs called Dual orexin receptor antagonists (DORAs). Had anyone here tried them?

I’m considering trying as I am at a high risk for Alzheimer’s and, while I don’t have trouble falling asleep, I have some trouble staying asleep, often waking up multiple times a night.

I’ve seen some discussion about DORAs on the r/insomnia subreddit, and it seems to have mixed reviews. But people on that sub also don’t seem to appreciate that DORAs aren’t intended for people who have trouble falling asleep, but rather intended to help you stay asleep.

Would love to hear any experience with these drugs. Thanks!

In 62 games this year in AA, he’s batting .326 with a .404 OBP, 15 2Bs, 15 HR, 40 RBIs, 27 BB, and only 35 Ks. Not sure why he’s only at 5 steals with grabbing 35 steals in 2024, but I’ll ignore that.

What else does this guy need to do to get promoted to AAA??

I am a specialist and just started looking for other jobs, as the hours and unpredictability working M&A transactions is becoming difficult for both me and my wife. As background, I’m probably at least 2-3 years away from making NEP.

This position opened up at one of the big banks that is exactly what I do, just in an advisory role for the private bank’s clients (both individuals and companies). The pay is actually the same that I make now (I haven’t received the offer yet but I’m being told all-in it will be at least the same). I’m told little to no work on weekends, which is one of the main drivers of my interest in this job (that and the fact that this is a growing area and a big focus of the bank).

My concern is the exit opportunities. If I don’t like the job after a year or two, I feel like I could return to a law firm (whether biglaw or a smaller firm). But after two years, I think it would be tough to return. Thus, I’m trying to asses the long term risk in moving to a non-legal role and how that could impact future exit opportunities if I feel I want to make a move down the road).

Has anyone made the jump from biglaw to a non-legal role? How did it turn out for you? Did you ever try to go back to a law firm afterwards?

Any experience or thoughts would be appreciated!

My ApoB one year ago was 76, now it’s 100. I’m a 40M and am not on any statin. Cedars Sinai, the hospital of which my doctor is affiliated, deems 100 to be normal. But I thought it should be much lower based on what PA has been saying.

Would you discuss the possibility of a statin with your doc? FWIW, the only thing I can think of diet-wise that changed is that I started eating one cup of mush (rolled oats) per day. I eat it for the protein (15g) and fiber (7g). But it has 8g of fat and 1.5g of saturated fat (I don’t consider that to be a high amount of fat). That’s the only thing I consistently eat that I can think of that may have had an impact on ApoB.

My LP(a) is 6, so I don’t think I am high risk. Below is my lipid panel if helpful:

Total Cholesterol: 181
LDL: 126
HDL: 47
Triglycerides: 47
LDL/HDL Ratio: 3.9
VLDL: 8