Are GLP-1s screwing with my duloxetine absorption ?
My duloxetine has not been effective for about a year now.
At first, I blamed my pharmacy switching me to a less effective generic (Ajanta)
But about a year ago, my GP put me on Metformin for pre-diabetes.
Metformin does delay stomach emptying.
Which means the duloxetine stays in the stomach longer, increasing the likelihood that duloxetine is broken down by the gastric acids before it reaches the small intestine for proper absorption.
Duloxetine is enteric coated to bypass the stomach acid, but is it enteric coated ENOUGH to withstand delayed stomach emptying caused by diabetic and weight loss meds ??
GLP-1s and diabetes meds are becoming so popular that I wonder if other folks are experiencing a reduction in the performance of their duloxetine ?
If this is a real thing, then some possible solutions would be
- stronger enteric coatings of oral duloxetine
- injectable (subcutaneous) duloxetine