Mild adenomyosis + recurrent chemical pregnancies. Anyone have success with progesterone?

I’m 27 and was diagnosed with mild/focal anterior adenomyosis after dealing with recurrent pregnancy loss. I have regular cycles, ovulate every month, and get pregnant pretty easily, but I’ve now had 5 losses, most around 4 weeks.
I had my first child without any issues, and I’ve wondered if something changed postpartum that may have contributed to the adeno. I also have basically no adenomyosis symptoms. My periods are regular, and I don’t have the heavy/painful periods I usually see people describe.
My OB has checked my progesterone over the past couple of years, and it seems to be getting progressively lower, although still high enough for me to ovulate. Everything else has looked good: eggs/ovaries, uterine lining, other bloodwork, and my husband’s semen analysis.
It feels like getting pregnant isn’t the issue, staying pregnant is.
I keep seeing women with adeno/RPL mention progesterone supplementation helping them finally maintain a pregnancy. Has anyone here with mild adenomyosis and very early/chemical losses had success with progesterone? If so, when did you start it, what dose did you use, and how long did you stay on it?
I’d really love to hear success stories or experiences from anyone with a similar situation.

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u/alwaysobserving_ — 2 days ago

Mild adenomyosis + recurrent early losses — progesterone success stories?

I’m 27 and was diagnosed with mild/focal adenomyosis after dealing with recurrent pregnancy loss. I have regular cycles, ovulate every month, and get pregnant pretty easily, but I’ve now had 5 losses, most around 4 weeks.
I had my first child without any issues, and I’ve wondered if something changed postpartum that may have contributed to the adeno. I also have basically no adenomyosis symptoms. My periods are regular, and I don’t have the heavy/painful periods I usually see people describe.
My OB has checked my progesterone over the past couple of years, and it seems to be getting progressively lower, although still high enough for me to ovulate. Everything else has looked good: eggs/ovaries, uterine lining, other bloodwork, and my husband’s semen analysis.
It feels like getting pregnant isn’t the issue, staying pregnant is.
I keep seeing women with adeno/RPL mention progesterone supplementation helping them finally maintain a pregnancy. Has anyone here with mild adenomyosis and very early/chemical losses had success with progesterone? If so, when did you start it, what dose did you use, and how long did you stay on it?
I’d really love to hear success stories or experiences from anyone with a similar situation.

reddit.com
u/alwaysobserving_ — 2 days ago

What should I expect at my first recurrent pregnancy loss specialist appointment? 5 losses

I have my first appointment with an RPL specialist coming up and I’m curious what to expect and what they may investigate beyond what a regular OB typically does.
I’ve had 5 losses total: 1 missed miscarriage and 4 chemical pregnancies. I’ve been diagnosed with mild focal adenomyosis, but otherwise my cycles are very regular, I ovulate normally, we’re both 27, husbands sperm is fine. and nothing else obvious has stood out. My progesterone has consistently been on the lower side after ovulation.
My regular OB was originally considering a diagnostic laparoscopy, but has decided to hold off and let the RPL specialist decide whether they think it’s actually necessary.
For anyone who has seen an RPL specialist:
What happened at your initial appointment?
What testing did they order that your regular OB hadn’t already done?
Did they look into uterine issues with an HSG, saline sonogram, hysteroscopy, biopsy, etc.?
Were you tested for chronic endometritis or other endometrial issues?
Did they do genetic testing on you/your partner?
Did they investigate male factors such as sperm DNA fragmentation?
If you had adenomyosis, did they think it could be contributing to the losses?
Did they recommend laparoscopy or feel it wasn’t necessary?
Did your specialist have a different approach to progesterone or monitoring very early pregnancies?
I’m mainly trying to figure out what an RPL specialist may be able to investigate that hasn’t already been covered by my regular OB. I’d love to hear what other people’s first appointments/workups looked like.

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u/alwaysobserving_ — 3 days ago

Laparoscopy after recurrent losses? What was your experience/recovery like?

Has anyone had a **laparoscopy after recurrent pregnancy losses** mainly to rule out things that weren’t showing up on extensive bloodwork or ultrasounds?
I’ve had recurrent losses and most of my testing has been normal, so I have a laparoscopy consultation coming up. I’m hoping to investigate anything that could potentially be contributing that imaging or bloodwork might have missed.
For anyone who has gone through this:
What should I expect going into the procedure and during recovery?
Is there anything you recommend doing or buying beforehand to make recovery easier?
How long did it take you to feel normal again?
If they found and removed endometriosis, adhesions, scar tissue, etc., did that make your recovery longer?
How long were you told to wait before TTC again?
Did anyone conceive naturally soon after the procedure?
I’m also planning to ask whether they can do an **HSG/chromopertubation to check my tubes, hysteroscopy to look inside the uterus, and an endometrial biopsy to test for chronic endometritis (CD138)** while they’re already investigating.
I’d especially love to hear from anyone whose bloodwork and ultrasounds looked normal but the procedures actually found something that could have been contributing to the losses. What did they find, and did treating/removing it make a difference for you?

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u/alwaysobserving_ — 6 days ago

Laparoscopy after recurrent losses? What was your experience/recovery like?

Has anyone had a laparoscopy after recurrent pregnancy losses mainly to rule out things that weren’t showing up on extensive bloodwork or ultrasounds?
I’ve had recurrent losses and most of my testing has been normal, so I have a laparoscopy consultation coming up. I’m hoping to investigate anything that could potentially be contributing that imaging or bloodwork might have missed.
For anyone who has gone through this:
What should I expect going into the procedure and during recovery?
Is there anything you recommend doing or buying beforehand to make recovery easier?
How long did it take you to feel normal again?
If they found and removed endometriosis, adhesions, scar tissue, etc., did that make your recovery longer?
How long were you told to wait before TTC again?
Did anyone conceive naturally soon after the procedure?
I’m also planning to ask whether they can do an HSG/chromopertubation to check my tubes, hysteroscopy to look inside the uterus, and an endometrial biopsy to test for chronic endometritis (CD138) while they’re already investigating.
I’d especially love to hear from anyone whose bloodwork and ultrasounds looked normal but the procedures actually found something that could have been contributing to the losses. What did they find, and did treating/removing it make a difference for you?

reddit.com
u/alwaysobserving_ — 7 days ago

Has anyone with mild/no symptoms had a laparoscopy and actually found something?

I’m dealing with secondary infertility and have mild focal adenomyosis. I’ve had 5 miscarriages in less than 2 years, usually around the same early point. I seem to have no problem getting pregnant, but staying pregnant is the issue. All my bloodwork has been normal, my cycles are regular, periods are light-moderate, and I have no spotting between periods.
I have a laparoscopy consultation coming up and asked my OB about doing a hysteroscopy and chromopertubation at the same time and treating anything they find, like endometriosis, adhesions, etc.
Did anyone have minimal symptoms/normal testing but find something during laparoscopy? And did treating it lead to a successful pregnancy afterward?

reddit.com
u/alwaysobserving_ — 12 days ago

Has anyone with mild/no symptoms had a laparoscopy and actually found something?

I’m dealing with secondary infertility and have mild focal adenomyosis. I’ve had 5 miscarriages in less than 2 years, usually around the same early point. I seem to have no problem getting pregnant, but staying pregnant is the issue. All my bloodwork has been normal, my cycles are regular, periods are light-moderate, and I have no spotting between periods.
I have a laparoscopy consultation coming up and asked my OB about doing a hysteroscopy and chromopertubation at the same time and treating anything they find, like endometriosis, adhesions, etc.
Did anyone have minimal symptoms/normal testing but find something during laparoscopy? And did treating it lead to a successful pregnancy afterward?

reddit.com
u/alwaysobserving_ — 12 days ago

5 losses in 2 years, mild focal adenomyosis, normal test results. What else should I be looking into?

Has anyone experienced something similar? I’m 28, healthy, moderately active, have normal/regular periods, and I track and confirm my ovulation every month.
I’m dealing with secondary infertility/recurrent pregnancy loss. I have a healthy child who was conceived naturally, and I had a normal pregnancy and birth with no fertility issues at the time. Since trying to have another child, I’ve had 5 pregnancy losses within the last 2 years, and almost every pregnancy ends around the exact same time, around 4 weeks 2–3 days.
I’ve had a pretty extensive workup. Clotting tests and other bloodwork have come back normal, and imaging looks good aside from mild focal adenomyosis. Nothing obvious has been found that explains why this keeps happening.
The one thing that has consistently stood out is my progesterone. My post-ovulation levels have been on the lower side and seem to have decreased over the years. Two cycles ago, I tried progesterone support, conceived naturally again, but still had another chemical pregnancy around 4 weeks.
At this point, I keep being told to continue trying, but having 5 losses happen repeatedly at almost the exact same gestational age makes me wonder if there’s something being missed.
For anyone who had recurrent very early losses/chemicals with otherwise normal testing, especially after previously having a healthy pregnancy: Did you eventually find a cause? Were there additional tests that helped, such as chronic endometritis, uterine/implantation issues, genetic testing, egg/embryo factors, or something else? Was there a treatment or change in your protocol that finally helped you carry past this point?
I’d really appreciate hearing from anyone who has been through something similar, especially those dealing with unexplained secondary infertility/recurrent loss.

reddit.com
u/alwaysobserving_ — 15 days ago

5 losses in 2 years, mild focal adenomyosis, normal testing. What else should I be looking into?

Has anyone experienced something similar? I’m 28, healthy, moderately active, have normal/regular periods, and I track and confirm my ovulation every month.
I’m dealing with secondary infertility/recurrent pregnancy loss. I have a healthy child who was conceived naturally, and I had a normal pregnancy and birth with no fertility issues at the time. Since trying to have another child, I’ve had 5 pregnancy losses within the last 2 years, and almost every pregnancy ends around the exact same time, around 4 weeks 2–3 days.
I’ve had a pretty extensive workup. Clotting tests and other bloodwork have come back normal, and imaging looks good aside from mild focal adenomyosis. Nothing obvious has been found that explains why this keeps happening.
The one thing that has consistently stood out is my progesterone. My post-ovulation levels have been on the lower side and seem to have decreased over the years. Two cycles ago, I tried progesterone support, conceived naturally again, but still had another chemical pregnancy around 4 weeks.
At this point, I keep being told to continue trying, but having 5 losses happen repeatedly at almost the exact same gestational age makes me wonder if there’s something being missed.
For anyone who had recurrent very early losses/chemicals with otherwise normal testing, especially after previously having a healthy pregnancy: Did you eventually find a cause? Were there additional tests that helped, such as chronic endometritis, uterine/implantation issues, genetic testing, egg/embryo factors, or something else? Was there a treatment or change in your protocol that finally helped you carry past this point?
I’d really appreciate hearing from anyone who has been through something similar, especially those dealing with unexplained secondary infertility/recurrent loss.

reddit.com
u/alwaysobserving_ — 16 days ago

5 losses in 2 years, mild focal adenomyosis, normal testing. What else should I be looking into?

Has anyone experienced something similar? I’m 28, healthy, moderately active, have normal/regular periods, and I track and confirm my ovulation every month.
I’m dealing with secondary infertility/recurrent pregnancy loss. I have a healthy child who was conceived naturally, and I had a normal pregnancy and birth with no fertility issues at the time. Since trying to have another child, I’ve had 5 pregnancy losses within the last 2 years, and almost every pregnancy ends around the exact same time, around 4 weeks 2–3 days.
I’ve had a pretty extensive workup. Clotting tests and other bloodwork have come back normal, and imaging looks good aside from mild focal adenomyosis. Nothing obvious has been found that explains why this keeps happening.
The one thing that has consistently stood out is my progesterone. My post-ovulation levels have been on the lower side and seem to have decreased over the years. Two cycles ago, I tried progesterone support, conceived naturally again, but still had another chemical pregnancy around 4 weeks.
At this point, I keep being told to continue trying, but having 5 losses happen repeatedly at almost the exact same gestational age makes me wonder if there’s something being missed.
For anyone who had recurrent very early losses/chemicals with otherwise normal testing, especially after previously having a healthy pregnancy: Did you eventually find a cause? Were there additional tests that helped, such as chronic endometritis, uterine/implantation issues, genetic testing, egg/embryo factors, or something else? Was there a treatment or change in your protocol that finally helped you carry past this point?
I’d really appreciate hearing from anyone who has been through something similar, especially those dealing with unexplained secondary infertility/recurrent loss.

reddit.com
u/alwaysobserving_ — 16 days ago

Success with 400–800 mg progesterone after ovulation?

Looking for success stories from anyone who used **400–800 mg of progesterone starting around 3 DPO** while TTC.
Did you have a history of recurrent miscarriages or chemical pregnancies? If so, do you think the higher dose of progesterone helped you finally have a sticky pregnancy? What dose were you on, when did you start it, and did you continue taking it after your positive test? If you were also taking baby aspirin, prednisone, or anything else alongside progesterone, I’d be interested to hear that too.
I’m not looking for medical advice, just personal experiences. Positive outcomes would especially be appreciated because I’m in my two-week wait and hoping to hear from others who have been in a similar situation.

reddit.com
u/alwaysobserving_ — 21 days ago
▲ 3 r/adenomyosis+1 crossposts

Anyone with adenomyosis and recurrent chemical pregnancies have success with progesterone?

I’ve had multiple back-to-back chemical pregnancies over the past couple of years, and after what felt like forever searching for answers, I was finally diagnosed with anterior adenomyosis.
This cycle I’m taking 400 mg of vaginal progesterone daily during the two-week wait in hopes that it will support implantation and early pregnancy.
I’m wondering if anyone else with adenomyosis and recurrent chemical pregnancies had success with progesterone. Did 400 mg end up being enough for you, or did you need a higher dose to maintain a pregnancy? If you had a successful pregnancy after recurrent losses, I’d really appreciate hearing your experience and what ended up working for you.
I know everyone’s situation is different, but I’m looking for some hope while I’m in the waiting period.

reddit.com
u/alwaysobserving_ — 23 days ago