Back on June 9th I obtained numb genitals and pfs style 4 am wakeups after .30mg anastrozole taken 8 hours after a supplement didn’t know contained dim called EVL test
Never crashed levels and all blood are normal to date
any hope of a natural recovery with HCG?
On 6/9 I crashed from .25 anastrozole 8 hours after a supplement I was unaware contained DIM
I am mostly okay with the exception of genital numbness encompassing glans and loss of full sensation on the rest except for temp.
I am all for not introducing random supplements and materials and waiting for this to resolve on its own if it ever does. However prior to this occurring I was and am a 90 mg weekly TRT regimen and 750mg mon wed Friday HCG regimen.
given Dr powers metabolite theory I wanted to know if it is wise to continue to run this regimen if I want my best possible chance at natural recovery.
I do find this particular genital numbness symptom odd and an outlier in most of these post ai cases considering this isn’t fin or an anti depressant but Dr powers did mention these conditions are very possible at resolving on their own provided you don’t self medicate.
I thought about this in depth what would this qualify under? Both have genital numbness as a trait.
What would you classify it as if genital numbness and 4 am wake ups and reduced ejaculate were the only traits
hard to find any info on this disorder
currently my second month of post anastrozole syndrome and I seem to have developed some sort of symptom similar to SIBO where the stomach growls in the mornings after a 4am wake up isnt diarrhea symptoms but during the day sometimes I feel it start up too it goes away later in the day though. Not sure if anxiety or not. but sometimes it does spark a gag reflex
other than this my symptoms include genital numbness (glans) and fragmented sleep.
I still have some libido and the ability to get erections with tadalafil. Morning ones are unaffected. Reduced ejaculate as well
is it worth getting this checked out?
Im not sure if this disorder is more so PSSD than pfs or what.
hoping for recovery but not expecting much so little info exists on these cases
On June 9th took a small amount of anastrozole 8 hours after a supplement containing D aspartic acid , tribulus , vitamin b and dim I did this out of concern that the d aspartic acid would raise my e2 levels my TRT clinic was closed for two weeks so I was lacking two weeks of HCG and TRT thoug h this since has resumed
since then
I experienced PSSD symptoms including fight or flight wake ups at 4 am (though I am able now to return to fragmented sleep) and genital numbness. All of my hormone levels are normal and never crashed. The onset was immediate.
Since I’m officially approaching the two month mark I wanted to know is there a history of this syndrome with anastrozole and has there been any real recovery stories? again My hormones never crashed leading me to believe this is some sort of PSSD type disorder
I still have erectile function/ejaculation though ejaculation is reduced as well as some thought based libido oddly as well.
I am also curious should I classify this as PSSD or PFS?
Starting in December 2025 I began a 160mg testosterone injection weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following
Vitamin D3- 50 Mcg
Vitamin B6- 11mg
Magnesium 160 mg
Zinc 30mg
Daspartic acid- 3120mg
Tribulus terrestris extract - 750 mg
Fenugreek extract- 500mg
DIM- 250mg
8 hours later on June 8th 2026 I took .25 Anastrazole believing the DAA would rise my e2 levels. within hours I developed immediate 100% sexual dysfunction this continues to date. —- to expand on this genital numbness
In addition to waking up every four hours when asleep. Nocturnal tumescence occurs
On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.
Its now been 37 days since the incident.
the following labs have been ran :
non sensitive e2 lab — 31 two days after incident , 58 to date
Sensative lab- E2 27 6/16/26 after resuming TRT
SHBG 18
Cortisol 21
DHT 32
the onset of this doesn’t match any of the ssri, pfs or even anastrazole related cases
should I ultimately chalk this as Post finasteride syndrome or should I rule out pelvic floor, other hormones.
worth noting glucose is slightly high and hdl /ldl are slightly out of range after this triglycerides are normal
Starting in December 2025 I began a 160mg TRT weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following
Vitamin D3- 50 Mcg
Vitamin B6- 11mg
Magnesium 160 mg
Zinc 30mg
Daspartic acid- 3120mg
Tribulus terrestris extract - 750 mg
Fenugreek extract- 500mg
DIM- 250mg
8 hours later on June 8th 2026 I took .25 Anastrazole. within hours I developed immediate 100% sexual dysfunction this continues to date. In addition to waking up every four hours when asleep.
Nocturnal tumescence appears to occurring normally
On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.
the following labs have been ran on 6/16 :
Sensative lab- E2 27
SHBG 16.5
Estradiol free serum MS - 38
Cortisol 21.1
A non sensitive lab was ran 6/11 that measured 31.
To date slight improvement on sleep with magnesium glycinate
appetite returned 6/25/2026 --
6/26/2026 -- sexual thoughts restored, incomplete erection occurred during sexual thoughts. -- broccoli consumed
6/30 partial manual erection from sexual thoughts sleep interruption continued but am able to sleep back without magnesium
7/2 and morning of 7/3 --- Was able to obtain erection by thoughts and wiggling back and forth. 3 times. achieved ejaculation -- broccoli consumed
7/7/2026 was able to obtain erection with thoughts.
7/10/2026 -- I was able to obtain an erection with thoughts and wiggling with 20mg Cialis. Genital numbness exists.
7/11 same result. Was able to calm system down briefly enough to gain somewhat appetite.
Lots of people argue this is a low e2 case however its been 31 days and the symptoms near mirror PFS. The only thing separating it is immediate onset the day of and while there is progressive improvement in some areas im curious what tests can I run to determine if this truly is a hormone issue or PFS?
Starting in December 2025 I began a 160mg testosterone injection weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following
Vitamin D3- 50 Mcg
Vitamin B6- 11mg
Magnesium 160 mg
Zinc 30mg
Daspartic acid- 3120mg
Tribulus terrestris extract - 750 mg
Fenugreek extract- 500mg
DIM- 250mg
8 hours later on June 8th 2026 I took .25 Anastrazole believing the DAA would rise my e2 levels. within hours I developed immediate 100% sexual dysfunction this continues to date. —- to expand on this genital numbness in particular I still get dreams oddly though I had a false sense of relief because I was able to get thought based function in late June
In addition to waking up every four hours when asleep. Nocturnal tumescence occured minimally the morning of 6/19 6/20 and better on 6/21, 6/26 and seems to be consistent
On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.
Its now been 31 days since the incident.
the following labs have been ran :
non sensitive e2 lab — 31 two days after incident
Sensative lab- E2 27 6/16/26 after resuming TRT
SHBG 16.5
Estradiol free serum MS - 38
Cortisol 21.1
To date slight improvement on sleep with magnesium glycinate still suffer with some fatigue thruout the day
the onset of this doesn’t match any of the ssri, pfs or even anastrazole related cases
I am wondering where should I begin neurology ?
Starting in December 2025 I began a 160mg testosterone injection weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following
Vitamin D3- 50 Mcg
Vitamin B6- 11mg
Magnesium 160 mg
Zinc 30mg
Daspartic acid- 3120mg
Tribulus terrestris extract - 750 mg
Fenugreek extract- 500mg
DIM- 250mg
8 hours later on June 8th 2026 I took .25 Anastrazole believing the DAA would rise my e2 levels. within hours I developed immediate 100% sexual dysfunction this continues to date.
In addition to waking up every four hours when asleep. Nocturnal tumescence occured minimally the morning of 6/19 6/20 and better on 6/21, 6/26
On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.
Its now been 17 days since the incident.
the following labs have been ran :
non sensitive lab — 31 two days after incident
Sensative lab- E2 27 6/16/26 after resuming TRT
SHBG 16.5
Estradiol free serum MS - 38
Cortisol 21.1
To date slight improvement on sleep with magnesium glycinate
appetite returned 6/25/2026 -- however on some days I am met with increased bathroom use.
Please advise if you believe this is a simple estrogen crash or if neurological attention is required.
Starting in December 2025 I began a 160mg TRT weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following
Vitamin D3- 50 Mcg
Vitamin B6- 11mg
Magnesium 160 mg
Zinc 30mg
Daspartic acid- 3120mg
Tribulus terrestris extract - 750 mg
Fenugreek extract- 500mg
DIM- 250mg
historically I have been a high aromatizer so 8 hours later on June 8th 2026 I took .25 Anastrazole. within hours I developed immediate 100% sexual dysfunction this continues to date. In addition to waking up every four hours when asleep. Nocturnal tumescence occured minimally the morning of 6/19 6/20 and better on 6/21. I woke up earlier however on 6/21 at 2:00 AM
Recent labs came in from 6/16 : Sensitive E2 --- 27
SHBG 16.5
Test 432
On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.
Its now been 12 days since the incident. I have scheduled an endo appointment 7/28/2026 in the event of no improvement.
Google AI indicates that this is merely an estrogen crash but I wanted to know what kind of timeline am I looking at before I deem this permanent damage
Could it be a mere estrogen crash or perhaps something bigger? Your thoughts?