u/anonanon-do-do-do

I was reading an unrelated article about a boy who was developing normally in the ‘Medical Mysteries‘ section of the Wa Po titled - “A toddler’s wobbly walk, hand tremors send parents on a medical journey“ and long story short it identified a genetic issue induced by bad flu he had 15ish years ago as a toddler. It affected his mitochondria.

“At first, Wangler said, he was skeptical. Like other clinicians, he’d seen several patients with DNM1L mutations, but he said their physical symptoms — such as early-onset epilepsy — were different, and more severe, than Oliver’s.“What changed my mind was finding other families who have similar symptoms with the same identical gene variant,” Wangler said.The DNM1L gene provides instructions for making a crucial protein that helps mitochondria, the tiny powerhouses that supply energy to cells, divide and maintain their shape, Wangler said. DNM1L performs a similar role in peroxisomes, small cellular structures that help process specific fats and protect cells from oxidative damage, he added.”

So I searched for if DNM1L had been related to long covid and found this recent article and thought I’d pass it along immediately. Has anyone researched this?

I share season NFL tickets with three friends. We are able to sell tickets for market price on a commercial ticket reseller. Sometimes those tickets sell for more than face value for popular teams and often they sell for under face value, for preseason games, games at the end of the season that don't matter, midweek games, etc. There are only about ten home games each year, including preseason games that always sell for about half of face value (we are required to buy them).

Historically, there are people who are the friends, family and acquaintances of us, that have bought tickets from us for face value. However, if we sell the best games to them at face value we are losing money. One such guy had bought tickets to one game, which he usually does. But he wanted to buy a second set of four tickets for the Packers, a game we were guaranteed to make more than face for.

AITA for telling my friends that I didn't want to essentially pay out of pocket for people to pay face value for the best games? For background, I have developed a chronic illness over the past two years and have been unable to attend any games. My health is now affecting my earnings and may force me into early retirement. I suggested we ask for a little over face, say 10% for games the team identifies as premium games. I also suggested they find a new fourth to take my share. Some of this, I recognize, is frustration with my inability to attend games, or much else for that matter. The guys essentially just responded with radio silence. We have been going together since 2003.

My wife planned a long weekend with a friend a couple of weeks ago. Morning of I tried to beg off. J was i. a downward spiral and felt the time away would allow me to reset. My HRV was still fine so a few days would surely have set me right. I got a full on guilt trip. I spent the second full day alone at the hotel recharging. We drove home five hours the last day and I have been spiraling downward since. we stayed in last night and I went to bed at 7pm. As usual recently, it arill took two hours to fall asleep, but after twelve hours in bed I slept 9 hours. I told her my smartwatch said I had bounced back from 30% to 60% body battery. She bitched about me rely on my watch again. I told her that the watch was the only reason I an still able to work part time and am not bed bound. I swear my best option for improvement is looking like divorce.

First of all, I have a pretty mild case of LC, mostly PEM and insomnia. My sleep finally started improving mid-April (took a vacation then) and May. Had RSV just before vacation too. A few months ago I started Wellbutrin 300mg and I take magnesium glycinate (250mg in the morning and another 250mg at night) and B12 for neuropathy in my feet for over a year (that and a 0.025% capsaicin roll on at night have really relieved burning symptoms). I was on nattokinase for months last year and didn't see any effect. But I finally gave in and started lumbrokinase mid-April and restarted 50 mg of trazadone. I also started CoQ10 Saturday and have seen a 20% uptick in nightly HRV since.

My HRV had been bad all February (we had repeated snow and I had to shovel keeping me in rolling PEM) and March and the beginning of April. Dipping as low as 50% below the lowest normal 7-day average value for me.

So, it looks like perhaps the lumbrokinase is having an impact. The CoQ10 shouldn't have had an early impact. Maybe it's a placebo effect (I work in drug dev), but whatever is going on, it can join the party of all the other magic beans I am taking for a while to see if I can ride the wave. Pretty soon I will have to start eating them with a spoon to save time. I really should break out my weekly grandpa pill box I use during travel just to save time.

Mornings - zyrtec, omeprazole, Wellbutrin and lumbrokinase

Lunch - multivitamin, probiotic, fiber gummies, CoQ10, magnesium glycinate, B12 complex, Vit D

Evenings - omeprazole, valsartan (blood pressure), magnesium glycinate, B12 complex (both have short half-lives so twice a day), trazodone (for sleep)

Thirteen different magic beans. Man, it is going to take FOREVER to figure out what is actually working and what I can get off.

I was also on Zepbound until the end of April. I lost about 25lbs (230 now, 6ft) but half of that was due to GI problems that really effed up my sleep. Quitting it definitely has helped my sleep a lot. It is in a big LC study and I took it for sleep apnea. Being obese is in itself inflammatory, so losing the weight was a big help. Cured my fatty liver in fact, but whew....am I glad to be off it!

Years ago I asked my dealer to look for the source of a soft almost moaning or hooting sound that seemed to come from the left front. It seemed like it could be tire noise. it is much worse now, but I also changed to Falken Wildpeak ATs last year. it does change if I am off the gas or in neutral. CV joints usually click. maybe a wheel bearing? anyone experienced this? 2022 limited but only 36k miles.