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u/longevity_protocols

r/HealthTech r/immortalists r/Supplements r/ResearchCompounds r/greyhairreversal r/GymMotivation r/Biohackers r/healthcare r/ScientificNutrition r/Cholesterol
Does spending more on healthcare actually translate into a longer life?
▲ 12 r/ResearchCompounds+2 crossposts

Does spending more on healthcare actually translate into a longer life?

An analysis based on WHO data compared healthcare spending across countries with life expectancy — and one contrast stands out:

🇺🇸 USA: $12,023 per person → 79.3 years life expectancy
🇨🇷 Costa Rica: $1,565 per person → 80.8 years life expectancy

The US spends almost 8× more, yet life expectancy is still lower.

The broader comparison shows that some countries appear to achieve better population-level outcomes with far lower healthcare spending.

🔗Full analysis

u/longevity_protocols — 8 days ago
▲ 33 r/ScientificNutrition+4 crossposts

Which supplements actually reduce epigenetic age in humans?

A systematic review analyzed 41 human intervention studies, including trials on omega-3, vitamin D, multivitamins, NAD+ precursors, polyphenols, and other popular longevity supplements.

The results were mixed. Some supplements produced repeated signals across next-generation epigenetic clocks, while others failed to deliver convincing effects despite strong biological theories and considerable hype.

The analysis also explains why improving a single clock result does not necessarily mean that the body has been genuinely “rejuvenated.”

🔗 Full analysis

u/longevity_protocols — 15 days ago
▲ 3 r/Biohackers

Can population health data estimate not only lifespan, but also healthspan and peakspan?

This free tool that uses extensive population data collected over more than 60 years across 183 countries to estimate:

• Lifespan — estimated total length of life
• Healthspan — estimated years lived in generally good health
• Peakspan — estimated period of high physical and cognitive capacity
• Health ROI (Return on Investment) — which of the many actions you could take are likely to deliver the greatest gains in lifespan and health

https://longevity-protocols.com/en/longevity-clock/

https://preview.redd.it/yxduk53i9seh1.png?width=2430&format=png&auto=webp&s=1bf1611b94b97a262d968804d8c1370eea2798d9

reddit.com
u/longevity_protocols — 29 days ago
▲ 7 r/immortalists

Can population health data estimate not only lifespan, but also healthspan and peakspan?

This free tool that uses extensive population data collected over more than 60 years across 183 countries to estimate:

• Lifespan — estimated total length of life
• Healthspan — estimated years lived in generally good health
• Peakspan — estimated period of high physical and cognitive capacity
• Health ROI (Return on Investment) — which of the many actions you could take are likely to deliver the greatest gains in lifespan and health

https://longevity-protocols.com/en/longevity-clock/

https://preview.redd.it/n9bpx5i7ireh1.png?width=2430&format=png&auto=webp&s=d0aa5f7d5226a4d2061013f79f10c15f68089a48

reddit.com
u/longevity_protocols — 29 days ago
▲ 244 r/immortalists

A 60-year-old who looks like a 20-year-old Greek god and other unbelievable longevity stories

- A 60-year-old who looks like a 20-year-old Greek god
- An 88-year-old woman completing a marathon
- A 90-year-old woman setting records in pole vault

...and many other jaw-dropping stories.

I still find it surprising how many people I talk to imagine aging as a stage where, after 60, all that remains is knitting and trying to make sure nothing hurts too much today.

This collection of remarkable “seniors” and their extraordinary achievements was brought together in one place to challenge that idea. 

This is what our old age can look like if we take care of our health today.

https://longevity-protocols.com/en/longevity-champions/

u/longevity_protocols — 2 months ago
▲ 297 r/immortalists+1 crossposts

Red wine and longevity — the research is pretty damning for wine lovers

Summary of current research on the effects of wine on health and longevity:

https://longevity-protocols.com/en/blog/why-red-wine-wont-help-you-live-longer/

For years, red wine has enjoyed a reputation as an “elixir of longevity,” mainly due to resveratrol—an antioxidant compound believed to protect cells. However, growing scientific evidence shows that it’s not the wine itself that supports the health of long-lived populations, but rather their lifestyle: natural physical activity, a plant-based diet, strong social bonds, and low stress levels. Meanwhile, alcohol—even in small amounts—can disrupt epigenetic processes and accelerate biological aging.

u/longevity_protocols — 3 months ago
▲ 0 r/greyhairreversal

Started going grey at 30. One year later my hair is coming back to its natural color — no dye

Not a filter. Not dye. Not photoshop.

I started going grey at 30 and had fully accepted it as just... genetics doing its thing. I wasn't particularly bothered by it, but when I overhauled my entire lifestyle a year ago for longevity reasons, hair repigmentation was genuinely the last thing I expected to see.

It took a full year and required changing pretty much everything — sleep, training, diet, supplementation, stress management. The grey hair reversal was a side effect I never planned for, which honestly made it more surprising when I started noticing it in the mirror.

I'm not selling anything, not promoting a product, and I want to be very clear — I did not use any hair dye or coloring treatments.

I wrote up the full details here, including a breakdown of the latest research on hair repigmentation, an assessment of various products I tried, and my personal conclusions — no affiliate links, no sponsored products, just my own honest findings:

longevity-protocols.com/en/knowledge-base/products/reversing-grey-hair/

Happy to answer questions. Curious whether anyone else has noticed something similar.

u/longevity_protocols — 3 months ago
▲ 0 r/Cholesterol

Lp(a) at 151.9 nmol/L (71.4 mg/dL) — the one marker I can't seem to influence. Anyone actually moved the needle?

I know, I know - Lp(a) is ~90% genetic and the standard line is "nothing you do will significantly change it." But I'm curious whether anyone here has genuinely experimented and seen results, or tried any of the newer drugs in development.

My context:

I'm 30-something, no chronic conditions, no medications. Lifestyle is arguably as clean as it gets:

  • Strength + endurance training 4–5x/week (VO₂max 57, body fat 13%, fat-free mass 86.7 kg)
  • Clean diet for years - whole foods, no alcohol, no smoking
  • HOMA-IR 1.06, HbA1c 5.2% - metabolically healthy
  • hsCRP <0.40 mg/L - no systemic inflammation
  • HDL 61.3, Triglycerides 81.4 - solid

The problematic part:

  • Lp(a): 151.9 nmol/L (71.4 mg/dL) - flagged high, significant CV risk
  • LDL: 124.84 mg/dL - hasn't moved in years despite everything
  • ApoB: 0.92 g/L - above the <0.80 target given my Lp(a) level

So essentially everything else looks decent, and then there's Lp(a) sitting there doing its thing regardless of what I eat, how I train, or what I supplement.

What I'm wondering:

  1. Has anyone actually seen their Lp(a) budge with any intervention - dietary, supplementation, lifestyle? Even a modest change?
  2. Anyone following or enrolled in trials for the newer Lp(a)-specific drugs (pelacarsen, olpasiran, lepodisiran)? Any real-world experience or data worth knowing?
  3. For those of you managing elevated Lp(a) long-term - what's your strategy? Just stack everything else in your favor (low LDL, low ApoB, low inflammation) and accept it?

I'm not expecting a miracle answer. Mostly curious whether anyone has done something beyond the standard "well, genetics" shrug - and whether the pipeline drugs are actually getting close to being accessible outside of clinical trials.

Appreciate any real experience or research rabbit holes worth going down.

reddit.com
u/longevity_protocols — 3 months ago
▲ 75 r/GymMotivation

One year between my worst and best shape ever

Left photo: before. I could barely climb the stairs to my floor without getting winded. Sleep was a nightly torment — couldn't fall asleep, woke up multiple times, brain fog all day long. Body fat was creeping up, I had the classic "dad bod" starting to form. Mentally I felt like a shadow my former self.

Right photo: one year later. Treating health like a serious project with KPIs, not a vague intention.

Some numbers after 12 months:

  • Biological age: 26.9 (I'm 37 chronologically) — based on epigenetic testing
  • DunedinPACE: 0.6 — my body ages 0.6 years per calendar year
  • VO2max: 57 ml/kg/min (elite category)
  • Body fat: 13.4%
  • Bone density T-score: 2.7 (doctor said it was the highest she'd ever seen)
  • Sleep went from a nightly struggle to falling asleep within minutes and jumping out the bed in the morning
  • Acne I'd had since my teens — gone
  • Hair I'd been losing since my 20s — visibly regrowing
  • Grey hair I'd had since my early 30s — gradually regaining its natural color
  • Teeth that needed treating every six months — dentist found nothing to treat for the first time ever

The protocol: structured resistance training 3x/week, Norwegian intervals 2x/week, zone 2 cardio, ~12k steps daily, 18:6 intermittent fasting, zero alcohol, consistent 8h sleep with a hard schedule, daily meditation, targeted supplementation, and a lot bloodwork and biomarker tracking.

u/longevity_protocols — 3 months ago
▲ 1 r/HealthTech

Lp(a) at 151.9 nmol/L (71.4 mg/dL) — the one marker I can't seem to influence. Anyone actually moved the needle?

I know, I know - Lp(a) is ~90% genetic and the standard line is "nothing you do will significantly change it." But I'm curious whether anyone here has genuinely experimented and seen results, or tried any of the newer drugs in development.

My context:

I'm 30-something, no chronic conditions, no medications. Lifestyle is arguably as clean as it gets:

  • Strength + endurance training 4–5x/week (VO₂max 57, body fat 13%, fat-free mass 86.7 kg)
  • Clean diet for years - whole foods, no alcohol, no smoking
  • HOMA-IR 1.06, HbA1c 5.2% - metabolically healthy
  • hsCRP <0.40 mg/L - no systemic inflammation
  • HDL 61.3, Triglycerides 81.4 - solid

The problematic part:

  • Lp(a): 151.9 nmol/L (71.4 mg/dL) - flagged high, significant CV risk
  • LDL: 124.84 mg/dL - hasn't moved in years despite everything
  • ApoB: 0.92 g/L - above the <0.80 target given my Lp(a) level

So essentially everything else looks decent, and then there's Lp(a) sitting there doing its thing regardless of what I eat, how I train, or what I supplement.

What I'm wondering:

  1. Has anyone actually seen their Lp(a) budge with any intervention - dietary, supplementation, lifestyle? Even a modest change?
  2. Anyone following or enrolled in trials for the newer Lp(a)-specific drugs (pelacarsen, olpasiran, lepodisiran)? Any real-world experience or data worth knowing?
  3. For those of you managing elevated Lp(a) long-term - what's your strategy? Just stack everything else in your favor (low LDL, low ApoB, low inflammation) and accept it?

I'm not expecting a miracle answer. Mostly curious whether anyone has done something beyond the standard "well, genetics" shrug - and whether the pipeline drugs are actually getting close to being accessible outside of clinical trials.

Appreciate any real experience or research rabbit holes worth going down.

reddit.com
u/longevity_protocols — 3 months ago
▲ 11 r/immortalists

Lp(a) at 151.9 nmol/L (71.4 mg/dL) — the one marker I can't seem to influence. Anyone actually moved the needle?

I know, I know — Lp(a) is ~90% genetic and the standard line is "nothing you do will significantly change it." But I'm curious whether anyone here has genuinely experimented and seen results, or tried any of the newer drugs in development.

My context:

I'm 30-something, no chronic conditions, no medications. Lifestyle is arguably as clean as it gets:

  • Strength + endurance training 4–5x/week (VO₂max 57, body fat 13%, fat-free mass 86.7 kg)
  • Clean diet for years — whole foods, no alcohol, no smoking
  • HOMA-IR 1.06, HbA1c 5.2% — metabolically healthy
  • hsCRP <0.40 mg/L — no systemic inflammation
  • HDL 61.3, Triglycerides 81.4 — solid

The problematic part:

  • Lp(a): 151.9 nmol/L (71.4 mg/dL) — flagged high, significant CV risk
  • LDL: 124.84 mg/dL — hasn't moved in years despite everything
  • ApoB: 0.92 g/L — above the <0.80 target given my Lp(a) level

So essentially everything else looks decent, and then there's Lp(a) sitting there doing its thing regardless of what I eat, how I train, or what I supplement.

What I'm wondering:

  1. Has anyone actually seen their Lp(a) budge with any intervention — dietary, supplementation, lifestyle? Even a modest change?
  2. Anyone following or enrolled in trials for the newer Lp(a)-specific drugs (pelacarsen, olpasiran, lepodisiran)? Any real-world experience or data worth knowing?
  3. For those of you managing elevated Lp(a) long-term — what's your strategy? Just stack everything else in your favor (low LDL, low ApoB, low inflammation) and accept it?

I'm not expecting a miracle answer. Mostly curious whether anyone has done something beyond the standard "well, genetics" shrug — and whether the pipeline drugs are actually getting close to being accessible outside of clinical trials.

Appreciate any real experience or research rabbit holes worth going down.

reddit.com
u/longevity_protocols — 3 months ago