u/psharmamd87

Came across an interesting study about beetroot juice and nitric oxide production.

Research suggests beetroot juice may help increase nitric oxide levels, which can support circulation, exercise performance, and healthy blood pressure. A lot of athletes and fitness enthusiasts seem to use it as a natural pre-workout for endurance and blood flow support.

Not claiming it’s a miracle drink, but the science behind dietary nitrates and cardiovascular health is pretty interesting.

Has anyone here tried beetroot juice consistently? Did you notice any difference in energy, endurance, or recovery?

PMID: 26653541

Link to article - https://www.espn.com/nba/story/_/id/48710416/darryn-peterson-says-high-doses-creatine-led-cramping

ptau 217 is a new blood test that detects Alzheimer's Dementia (AD) 10 years before symptoms.

Here's my video reviewing the biology, how to get the test & how to deal with the results.

Ptau-217 is becoming the gold standard for testing to the point where the efficacy of disease modifying drugs are judged based on this test - a huge innovation in AD prevention.

The arms race continues with a drug that hits 4 receptors - GLP-1, GIP, and 3 PPAR receptors

Blood pressure is incredibly important but also easier to treat without meds than most people realize. In this video I break down the new blood pressure guidelines as well as the 5 different lifestyle levers you can pull to reduce it including approx how much these can reduce your values

I think it's key to note how many health influencers, even ones who claim to have credentials (like an MD here in Shawn Baker's case), conflating correlation with causation.

Is it deliberate, lazy, or ignorance? I'm not sure, but the key here is there is no explanation for WHY this effect might be happening, which is a surefire sign that it's worth ignoring

This kind of communication is rampant and we need to be careful of it or we'll go down rabbit holes that aren't real and more importantly people can get bad health advice and be harmed.

I'm continuing laying out my longevity protocols, continuing to go through the cardiac section.

This one is about arrythmias - what they are, why we care about them from a lifespan and healthspan standpoint, how to evaluate for them, and how to manage them.

Here's my quick, easy to digest summary of this key aspect of heart health

https://vitaveda.substack.com/p/arrythmia

Really interesting article showing that inflammation was the best predictor of cardiac events or death in folks undergoing stents who also had LDL < 70 (likely all via treatment). Notably triglycerides did not have the same impact.

This suggests inflammation is a key necessary component in ASCVD, maybe even sufficient (though I'm not convinced).

Now why did they still have cardiac events when their cholesterol was controlled? I think it could be because they already had a lot of disease. These were not people who were fully healthy at a time. If they had been fully healthy, I'm not sure if the inflammation alone would be enough to cause disease progression.

Full study - https://academic.oup.com/eurjpc/article/33/5/742/8088269?login=false

A crazy stat - 100% of brains had microplastics in them. But they found a higher concentration of microplastics near brain tumors, suggesting this could be a mechanism by which tumors arise

Source - https://www.nature.com/articles/s44360-026-00091-4

This is a cool article displaying a concept I've been obsessed with for a while - gamifying "boring" things that are good for you. I think this is perfect for Longevity

A lot of Longevity is keeping your habits in line consistently for decades. That can become mundane, so the behavioral side is challenging. But what if you could gamify it to make it more engaging? It's potentially less boring than Trauma Triage Guidelines, and they were able to do it successfully.

Even a 10% increase in people sticking to their habits would make a massive difference over time, so it doesn't have to be a cure all

Have any of you been able to gamify elements of your Longevity? Would love to hear what worked

This came in email. At the moment the only meds offered are tadalafil (erectile dysfunction), estradiol cream (for vaginal erosion in menopause), metformin (a diabetes med but not the best one), acarbose (similar to metformin), tretinoin (for skin), and minoxidil (for hair growth).

Seems less about Longevity and more focused on generic consumer meds, specifically going after HIMS / HERS, RO and other consumer telehealth brands.

My guess is these meds are Blueprint branded and like the other companies Bryan aims to make margin on the medications - it's a standard healthcare playbook

Interesting to see WHOOP starting to move into traditional healthcare. The Medicare ACCESS program is not full medical care, and it's questionable how much the Whoop's data will be helpful, but interesting to see their strategic move

(I'm a medical director at a company that is providing these services as well so I have a deep knowledge of how it will work)