u/rnx990

I’ve struggled with anxiety, depression, and panic attacks since 2014. Paroxetine (Paxil/Seroxat) worked amazingly well for me for several years, but after a major relapse in 2019, I never fully returned to how I was before.

Since then, I’ve tried fluoxetine, venlafaxine, desvenlafaxine, duloxetine, vortioxetine, moclobemide, bupropion, lurasidone, clonazepam, bromazepam, diazepam, propranolol, and CBT. Some helped temporarily or partially, but nothing has given me stable, lasting improvement.

My main symptoms now are persistent anxiety, depression, low energy, panic attack with agoraphobia,anhedonia, lack of motivation, and sometimes a dream-like/unreal feeling.

Has anyone been in a similar situation and eventually found something that truly worked? Was it a medication combination, augmentation strategy, TMS, esketamine, or something else?

I’d really appreciate hearing real experiences from people who went through multiple treatment failures and eventually improved.

I’ve struggled with anxiety, depression, and panic attacks since 2014. Paroxetine (Paxil/Seroxat) worked amazingly well for me for several years, but after a major relapse in 2019, I never fully returned to how I was before.

Since then, I’ve tried fluoxetine, venlafaxine, desvenlafaxine, duloxetine, vortioxetine, moclobemide, bupropion, lurasidone, clonazepam, bromazepam, diazepam, propranolol, and CBT. Some helped temporarily or partially, but nothing has given me stable, lasting improvement.

My main symptoms now are persistent anxiety, depression, low energy, panic attack with agoraphobia,anhedonia, lack of motivation, and sometimes a dream-like/unreal feeling.

Has anyone been in a similar situation and eventually found something that truly worked? Was it a medication combination, augmentation strategy, TMS, esketamine, or something else?

I’d really appreciate hearing real experiences from people who went through multiple treatment failures and eventually improved.