u/roman_arc_0695

Mislim tisti, ki ste relativno zdravi?

This was approved back in early April, but it's finally hitting pharmacy shelves. It's a daily pill, and the biggest selling point is that it has no food or water restrictions at all, you can take it any time of day, with or without food. The weight loss in the ATTAIN-1 trial was about 12-15% at the highest dose, which is less than injectables but still solid. The cash price through LillyDirect is around 25 per month with commercial coverage or 149 for self-pay. I'm seriously considering switching from Mounjaro just to get rid of the weekly needle ritual.

For those watching the pipeline, CagriSema (the semaglutide/cagrilintide combo) is still on the horizon. Despite some trial disappointments earlier this year, Novo Nordisk is anticipating a US approval decision in the fourth quarter of 2026, followed by a launch early in 2027. The company submitted applications based on their REDEFINE 1 and REDEFINE 2 trials. So, new tools might be coming to the toolbox by next year.

seen like five posts this week of people convinced they got a bad vial because they're two weeks in and not feeling anything dramatic. your vial is fine. reta is not sema. it doesn't hit like a truck for everyone and appetite suppression can take weeks to kick in properly. check your dose calculation, check your injection technique, give it a full month and look at the scale trend before you start pointing fingers at your supplier. that's all.

This one really caught my attention because type 1 diabetes (T1D) is often left out of GLP-1 research. The new analysis from the Johns Hopkins Bloomberg School of Public Health looked at over 10,000 adults with type 1 diabetes, some of whom were prescribed GLP-1s like semaglutide (Ozempic) or tirzepatide (Mounjaro).

The five-year risk of major cardiovascular events (such as heart attacks) was reduced by about 15%, and the risk of end-stage kidney disease was reduced by about 19% for patients taking GLP-1s compared to those who weren't. These are pretty meaningful numbers, especially for a population that has historically had limited treatment options beyond insulin.

The study authors noted that landmark clinical trials have already found that GLP-1s lower the risks of major cardiovascular events and kidney failure in type 2 diabetes patients by roughly 20%, but this is one of the first large-scale studies to look specifically at type 1 diabetes.

I have PCOS and have been on Metformin for years. It helps a bit but the side effects are bad, and I have been thinking of switching to a GLP-1 for a while. Then just last month I saw this meta-analysis, which I found quite interesting. By 218 women in total, the researchers pooled data from the four trials that were randomized controlled. When GLP-1s were compared to Metformin, the first ones performed better on almost every hormonal marker.

In particular, there was a significant decrease in testosterone, DHEA-S, and androstenedione. In addition, insulin resistance (HOMA-IR) showed a striking improvement. The figures were statistically significant across the board which is pretty nifty for a meta-analysis of quite small trials. The researchers mention a strong variability between the various studies, so we must be cautious. The trials lasted a mere 12 weeks, leaving us unaware of potential long-term consequences. The signal increasingly suggests that the GLP-1’s are likely to be more efficacious for the hormonal and metabolic aspects of PCOS than what I’m on now.

I've been on Zepbound for 8 months. Total weight lost: 42lbs. Total out-of-pocket cost (including copays, supplies, and extra doctor visits): $2,856. The cost per pound is $68/lb

That's 68 for every pound I lost. For perspective : Weight Watchers is about 20/lb (based on average loss of 10lbs in 6 months at $200 total). But Weight Watchers didn't work for me. Is it worth it? I mean yes it is in my own opinion since my health is better and my quality of life is better, but the cost is real.

Got to the gym today and went to the locker room to put my stuff away before my lift. I walked in and overheard three guys talking about their cycles. One of the guys was absolutely massive and peeled. He points to me and says how he wishes he had my size. I laughed and told him his chest was way better than mine and he was much leaner. He just shook his head and said I was way bigger than him and he still feels flat. I was maybe two inches taller but I definitely did not look bigger than him at all. I joined the conversation for a bit and he started talking about how he feels like he needs to add Tren or push his doses higher because he still feels small and hates how he looks. I felt bad because this guy was literally huge and already running heavy compounds, but he completely lacked any confidence in his actual physique. It is crazy how we can run all these different PEDs to look good and still think we look like trash to ourselves. Just a reminder to compliment the guys at the gym and support each other, because some guys are really struggling with how they view themselves no matter what they are taking.

I planned my zepbound start for January 1st. Here's why: my insurance has a $3,000 deductible. January is when the deductible resets.

By starting in January, all my zepbound costs (plus other medical expenses) count toward my deductible. By March, I hit the deductible. For the rest of the year, my zepbound copay dropped from 45 to 50.

If I had started in October, I would have paid full price for October-December, then the deductible would reset in January, and I'd pay full price again.

I’ve been searching for a trustworthy peptide supplier for the past few weeks and keep coming across a handful of different names. I’ve had a few people recommend some places through direct messages and have seen some good feedback about them.

What I really don't understand though is why it is so hard to find reliable places to get regular peptides when it is so easy to find glp1s everywhere right now.

Compared to GLP-1 alone, the combo reduced major adverse liver outcomes by 39% and MACE by 35%. Compared to SGLT-2 alone, the combo reduced liver outcomes by 43% and MACE by 20%. This is a target trial emulation using US Marketscan data with over 25,000 patients. Follow-up was short (about 6 months), but the signal is strong.

I have NAFLD and have been on Mounjaro for a year. My liver enzymes are finally normal. But this makes me wonder if adding an SGLT-2 inhibitor (like Jardiance) could give me even more protection.

When you update your meds at the doctor, are you actually telling them about your grey market GLPs like Reta? I don't want a lecture or to ruin my insurance, but part of me thinks I should be upfront since it is my health and he might actually help me. Do you guys just keep quiet because it really doesn't matter as long as you feel fine, or do you come clean to your GP?