What is happening with DFTX
For anyone saying the results of DT120 are on par with anything, you're talking out of your ...
The results are unprecedented, this is head-to-head:
Auvelity's pivotal GEMINI trial showed a 3.8-point placebo-adjusted MADRS improvement at Week 6 and 2.2-point separation at Week 1.
DT120 reported:
- 14.2-point placebo-adjusted improvement at Week 1
- 8.1-point placebo-adjusted improvement at Week 6
- 7.3-point placebo-adjusted improvement at Week 12
Those numbers are dramatically larger. Based solely on effect size, DT120's antidepressant signal is roughly 2–4 times larger than Auvelity's.
Comp360 (not completely comparable because TRD) but someone mentioned DFTX saw similar results in TRD so make of that what you will:
Using the same style as the Auvelity comparison:
COMP360's best publicly reported studies showed approximately:
- 6–7 point placebo-adjusted MADRS improvement at peak
- 4–6 point placebo-adjusted separation around Week 6
- 2–4 point separation by Week 12
DT120 reported:
- 14.2-point placebo-adjusted improvement at Week 1
- 8.1-point placebo-adjusted improvement at Week 6
- 7.3-point placebo-adjusted improvement at Week 12
So less difference but still meaningful
This is why the stock is up because investors are finally waking up to what we knew all along...
For reference Axsome today is trading at 12.6 billion market cap.
Also stop remission rates for a single dose to a daily pill.