Motivation, executive dysfunction and treatment augmentation of atomoxetine and venlafaxine

I have a problem with my current adhd treatment protocol and I dont really know how to change it

Im currently taking venlafaxine 150mg and atomoxetine 60mg for social anxiety and adhd respectively. My social anxiety is great, but my adhd seems to be a little bit harder to deal with. I am most certainly better at focusing for longer periods of time and its retained better. But i still have bad task initiation paralysis and I procrastinate way too much. I have taken methylphenidate before, but switched to atomoxetine because methylphenidate is too expensive and is a hassle to deal with because its treated like some fucking illicit drug in my country. Same problem with vyvanse. Modafinil is also expensive and doesn't seem to have any advantage in treating adhd. I have considered bupropion, but it is much more potent of an inhibitor of CYP2D6 compared to atomoxetine so it will reduce the more potent O desmethylvenlafaxine concentration.

Clonidine is available over the counter for me, but effects seem to be modest at best and it probably wont really increase motivation.

Agomelatine is maybe another thing I thought might be good.

Im thinking something with more of an effect on dopamine might be useful, because I likely have close to full NET occupancy

As for supplements, l theanine and coffee combo is nice. The other stuff(alpha gpc, lionsmane, magnesium l threonate, etc)I found to be more useful for increasing memory retention and not motivation

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u/theobromine69 — 2 days ago

Is bupropion any good for ADHD and as a nootropic?

I'm currently taking venlafaxine xr 150mg and atomoxetine 60mg. I have in the past used venlafaxine and methylphenidate. My problem is that the atomoxetine doesn't really work as well as I had hoped. Bupropion has more of an effect on dopamine and will probably also raise venlafaxine due to CYP2D6 inhibition. Would it work better that atomoxetine?

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u/theobromine69 — 1 month ago
▲ 6 r/AskChemistry+1 crossposts

Magnesium L threonate synthesis

I am wanting to make my own magnesium l threonate supplement because it is very expensive and I think it will be fun.

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My idea is based on this paper, specifically 2.1.1

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They react the ascorbic acid with magnesium carbonate first, but idk why? Or if it matters.

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My plan is to react the ascorbic acid with an excess of hydrogen peroxide, add magnesium carbonate, separate the threonate salt from the oxalate salt and precipitate out the threonate with ethanol.

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Would this work in practice? Am I missing something? Any advice is appreciated

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Also this is what I think happens, if someone could illuminate me on the mechanism and point out mistakes

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u/theobromine69 — 2 months ago