r/CTE

▲ 6 r/CTE

Is CTE all about many small hits or does few big hits also cause CTE?

Because i read that it is the 100s of small hits that causes CTE, thats why American Football and Boxing have a big CTE risk? But what about big hits? At the same time people call Power Slap one of the worst sports for CTE, even if you take max 3 hits in a match. How do few big hits cause CTE compared to 100s of small hits?

reddit.com
u/Enough-Lead48 — 5 days ago
▲ 16 r/CTE

CTE identified in 33 Australian football players, including a 23 year old - Dr. Ann McKee argues contact sports may need to wait until informed consent is possible

Australian football is facing a growing brain health dilemma as evidence accumulates around repetitive head impacts and CTE. Researchers and clinicians say the focus on concussions alone may miss a larger issue: the thousands of smaller impacts players absorb over years of participation. The AFL says it is making safety changes, but several experts interviewed believe action is not keeping pace with what emerging evidence is showing.

Key points:

• CTE has now been identified in 33 former Australian Rules football players, including players in their 20s, 30s and 40s.

• The youngest Australian football player diagnosed with CTE was 23 year old Nick Lowden.

• Dr. Ann McKee, who has diagnosed CTE in hundreds of athletes and examined thousands of brains, argued that there is “nothing magical” about age 14 and said she would prefer delaying tackle sports until athletes are old enough to understand and consent to the risks, potentially 18 or older.

• The article emphasizes that CTE is increasingly viewed as a disease tied to cumulative head impact exposure, not just diagnosed concussions.

• Experts are calling for stronger prevention efforts, including reducing contact exposure in training and rethinking youth contact rules.

abc.net.au
u/PrickyOneil — 5 days ago
▲ 6 r/CTE

is there a chance my disabled brother will develop CTE?

I probably wont get any responses but ill just throw this out there because why the hell not. 

okay i will dumb this down a LOT. so basically my younger brother has severe autism/learning disabilities. he can speak but he’s considered nonverbal because he cant actually form a sentence thats coherent. he needs help washing, eating, going to school etc. 

so heres the thing. when he has a meltdown (which is often and can happen because of literally nothing) he gets violent and aggressive. one of the things he does and has always done is bashing his head against walls. 

now im very aware that you cant diagnose cte until someone is dead and im also aware he literally can’t communicate if he has something like this. but when i learnt about cte more i started thinking that maybe he might have this. im just worried. hes always been violent and know hes growing and getting stronger. i know cte can make you paranoid and have violent outbursts. but im worried that he is going to get worse. 

ive always lived in a hostile environment but i get to leave in a year and 6 months. my other younger brother doesnt get to. what will happen when he gets MORE violent? my parents and the disability support team isnt going to assume cte, thats for sure. what if he kills somebody? thats something thats been running through my head. 

all i want to do know is if this is possible or likely. thats it. 

reddit.com
u/smashedmelonz — 6 days ago
▲ 7 r/CTE+1 crossposts

24yo and getting better. Am I doomed for my older years?

I've been recovering what my doctors think is just PCS for about 7 or 8 years now. The usual garbage: headaches, anxiety, dizziness. That exciting headache where it feels like your brain is pressing against the front of your skull.

I've been fighting for the past 4 years to try and do my highschool equivalency, and I'm seeing some real progress. I'm still a sharp guy, just in controlled settings I suppose.

Things are on a good track, I'm hoping to get a part time job soon (I'm on disability rn), and my tolerances before I get overwhelmed with symptoms are getting higher. Just slowly. At the moment I really struggle with crowds, but exposure therapy is working.

I guess I just wonder, is this recovery only going to be temporary? Am I already so damaged I'll be miserable in my 40s and beyond? I know I need to keep at it no matter what, but I just really don't want to get CTE. It's terrifying to me.

I have had a lot of concussions over the years. I've lost count, but we're looking at 10+ at least in my teenage years from sailing and hockey. They progressively got worse. The first ones just meant I had to take a few weeks off some of my harder courses, but by the time I was 16/17 I had a few knocks that made me take a few months away from school outright, and then the big one when I was 17 that forced me to drop out and I'm still dealing with it.

Is the fact that I'm getting better an indicator I'm not "destined" to get CTE? Or is it still likely my progress will only be temporary, and I won't get to have many more happy decades?

I'm sorry if this is gloomy, I'm trying, it's just scary.

reddit.com
u/Spatrico123 — 12 days ago
▲ 23 r/CTE+1 crossposts

CTE found in 15 yo football player

There's a link between head trauma and psychosis

u/foreveraloneok — 13 days ago
▲ 13 r/CTE+1 crossposts

TriCelX to Launch Phase 1/2 Wharton's Jelly Stem Cell Trial for CTE, Developed with the DoD

Key Points

  • TriCelX has received FDA clearance to begin a Phase 1/2 trial of XytriX in chronic traumatic encephalopathy, or CTE.
  • The company says this is the first time a cell therapy will be studied in this condition.
  • The open-label dose-escalation study will test safety, tolerability, and early signs of activity in adults with probable CTE, including veterans and former contact-sport athletes.

TriCelX, a Texas-based biotech company, has received FDA clearance to start a Phase 1/2 clinical trial of its allogeneic wharton’s jelly-derived MSC therapy, XytriX, in chronic traumatic encephalopathy, which they say is the first cell therapy trial in this condition.

XytriX was developed with the Department of Defense under the Blast Overpressure Safety Act, which aims to study and treat concussive injuries in the armed forces.

Trial design and patient population

The trial is an open-label, three-cohort dose-escalation study using a 3+3 design in adults with probable CTE. Participants will receive XytriX by intravenous and intrathecal administration. Eligibility will be based on a formal diagnosis of Traumatic Encephalopathy Syndrome at the probable level by a qualified neurologist using the 2021 NINDS TES criteria.

The study is designed to assess both safety and preliminary efficacy over 24 months. The main evaluations include:

  • Treatment-emergent adverse events
  • Serious adverse events
  • Dose-limiting toxicities
  • Changes from baseline in neurocognitive outcomes
  • Changes from baseline in behavioral outcomes
  • Changes from baseline in functional outcomes

The protocol also includes exploratory biomarker and imaging measures intended to help characterize biological activity and support planning for a later controlled trial. These measures include:

  • Serum neurofilament light chain, or NfL
  • GFAP
  • Plasma phosphorylated-tau species
  • Structural MRI
  • Diffusion tensor imaging, or DTI
  • Functional MRI

The trial will enroll adults with probable CTE from two groups highlighted in the release:

  • Blast-exposed service members and veterans
  • Former contact-sport athletes

Why the study matters

CTE is a progressive tauopathy associated with repeated head trauma and blast exposure, and there are no approved treatments that address the underlying disease. The disease burdens both military and sports populations, including prior findings in former NFL players and Navy SEALs. TriCelX says XytriX is designed to target chronic neuroinflammation and tau pathology linked to CTE.

Because this is the first cell therapy study in CTE, the trial may help define an early framework for evaluating future programs in the indication.

u/Jewald — 13 days ago