r/NicotinamideRiboside

"...Restoring NAD levels through supplementation with its precursors or pharmacological inhibition of CD38 activity effectively alleviated the pathological symptoms of colitis...These findings identify macrophage CD38 as a critical regulator of intestinal inflammation and highlight the CD38/NAD axis as a potential therapeutic target for IBD."

“…Clients receiving IV NAD+ reported moderate to severe gastrointestinal symptoms, elevated heart rate, & chest pressure during infusion, while those receiving IV NR reported mild tingling or cramping. Symptoms ceased upon completing infusions. The moderate to severe symptoms from IV NAD+ resulted longer infusion times (97mins) compared to IV NR (37mins). Renal & hepatic biomarkers showed no adverse changes; ALP decreased significantly in NAD+ group but remained within normal ranges. Metabolic markers suggested improved glucose metabolism 30 days post NR & mixed lipid changes post NAD+. QoL measures showed NR group had 30 minutes more total sleep, lower resting heart rate & breath rate, while NAD+ group had higher RMSSD. Minor yet non-significant QoL improvements occurred in both groups….”