Started NAD+ at 25mg, 2x a week, and instead of giving me energy… it makes me SO sleepy and drowsy 😭 I feel unproductive basically the whole day.
Has anyone else experienced this? Did you lower the dose, change the frequency, or switch to something else? Would love to hear what worked for you!
A usual peptide Monday morning routine i was sitting and doing my injection firstly done with my ghk cu and kpv on my belly fat then went on for my NAD+ peptide injected to my outer left part of my thigh right after like less than 15 seconds to my surprised and never thought will experience the most terrifying event in my life felt sudden tingling and numbness in my left foot radiating and spreading to my upper legs i was terrified and trying to massage my legs hoping things could get better i grab my phone and ask google about hitting a nerve by needle symptoms i tried to relax because i feel like panicking and my left leg continue to get numb but i still can move my legs while trying to relax i felt like the tingling and numbness spread to my left arms neck and head like electric shock but still i can move i was like feeling muscle cramps and spasm all over my left body i waited and relax took a deep breath and everything back to normal in less than a minute like after i get back to normal and told my self wtf was just happened i almost called an ambulance because i thought was having stroke and heart attack and now i feel traumatize and contemplating if i would still continue doing NAD+ peptide.
I’m really looking for answers! Please help, I’m in much needed help for energy! I’m on Tirz and SS-31 also getting ready to incorporate MOTS-C. I’m wanting to add NAD but not knowing which one! Thanks in advance
I keep seeing NAD+ described as "cellular energy currency" and leaving it there, which honestly undersells what's going on. There's a specific enzyme relationship here that doesn't get mentioned enough.
PARP1 is the protein that shows up first when DNA gets a double-strand break. It uses NAD+ directly as a substrate to build these poly-ADP-ribose chains that basically flag the damage site so the rest of the repair crew knows where to go. That part's pretty well known.
What's less talked about is that SIRT6, which is itself an NAD+-dependent enzyme, is what activates PARP1 in the first place. Mao et al. found that SIRT6 physically attaches to PARP1 and modifies it in a way that ramps up its repair activity under oxidative stress (Science, 2011, PMID 21680843). So you've got NAD+ needed twice in the same chain of events, once to power the enzyme that turns the system on, and again to fuel the repair enzyme itself.
That's probably part of why NAD+ decline gets treated as a bigger deal than a simple "less fuel in the tank" story. You're not just running low, you're losing the thing that activates the activator.
Wrote up the fuller mechanism (base excision repair, where SIRT6 fits, the whole chain) here if anyone wants to go deeper: https://spartanpeptides.com/blog/nad-plus-dna-repair/
Research use only obviously. Curious if anyone's seen good independent replication on the SIRT6-PARP1 interaction outside the original Mao paper, that's the piece I haven't dug into yet.
Salve a tutti sono una donna di 53 anni in menopausa e con terapia ormonale sostitutiva,
Il mio medico mi ha consigliato di inserire Ostarine 10 mg 3 volte a settimana per supportare la massa muscolare,mi alleno 4 volte a settimana con i carichi.
Insieme anche il peptide NAD + e il peptide Glow
Ora questo cocktail di roba un po’ mi preoccupa
Vorrei sentire donne della mia età come si trovano con Ostarine ed il loro fegato