u/RaisingNADdotcom

The end of September will mark 5 years dealing with this chronic illness that robbed everything from, but I see the light at the end of the tunnel. I was so sick first couple years could barely leave the house mainly bed and couch bound. Had trouble opening my eyes. Extremely tired mentally, physically and the worst PEM imaginable. Difficult speaking and couldn't stay awake to save my life. Couldn't think or read at all really. Loss of internal monologue for almost first year. But fast forward almost 5 years, and I'm 95% recovered! I'm in grad school thriving (and I go in person) and frequently hike. Able to read, watch movies and TV shows (couldn't tolerate these for 3 years). For almost 2 years I just accepted I was doomed to a life of suffering. I have come so far in my recovery journey and hope that everyone here in this sub will eventually recover. No one on this planet deserves long covid or ME/CFS for that matter.

Things I have done to heal:

1. Extremely gentle reintroduction of activities, physical and mental . This was probably the biggest thing. Just very slowly and carefully adding more stimulus in and painfully recalibrating my baseline higher. Extremely difficult. Like running into a brick wall thousand of times hoping you'll break through. DISCLAIMER: be very cautious with this as there is very high likelihood you could get worse. I had to experiment and failed so many times got set back many months. Don't do any graded exersise at all throw out the whole idea of anything "graded". Just take things so slow.

*NOTE: I do not endorse brain retraining or any of that quackery. Anything with a price attached to it is malicious especially with how much we have had to suffer.

2. Tru niagen - 300 mg

3. Red light therapy 2x a day

4. Zyrtec 24 hr

5. Lots of professional full body massages with calm, serene environment.

6. finding hobbies compatible with my baseline so that I can find some fun despite the misery.

To give you perspective, for first 2.5 years every single day of every month on my calendar could be marked as "Extremely tired/no capacity" and now I can no longer mark that on any days. Most days are "excellent" and make only a couple that I'd mark as "slightly decreased capacity". Overall I can do everything I did before I got like this with exception of flares once or twice a month.

Don't ever give up on your recovery and remember that you are all the real superstars!

As soon as I am completely healed I am getting a Rolex with the Latin phrase "Superavi impossibile" engraved on the back as a present to myself. It means "I prevailed over the impossible."

I keep seeing NAD+, NMN, and NR described as if they are interchangeable, but it doesn’t seem that simple. I’m trying to understand the difference before spending money.

I’ve looked at Tru Niagen, Renue By Science, and the NAD+ product from LiveGood. For those who have researched this properly, what human evidence or label details actually matter? I’m more interested in measurable results than feeling a quick energy boost.

Among people with peripheral artery disease (PAD) age 50 and older, the investigators will test the hypothesis that PAD participants randomized to nicotinamide riboside (NR) will have greater improvement or less decline in six-minute walk distance at six-month follow-up, compared to those randomized to placebo. The study will randomize 250 participants with PAD age 50 and older to one of two groups for six months: nicotinamide riboside vs placebo. Our primary outcome is change in six-minute walk distance at six-month follow-up. Secondary outcomes are Walking Impairment Questionnaire (WIQ) distance score, PROMIS Mobility score, calf muscle perfusion (measured by magnetic resonance arterial spin labeling (MRI ASL)), oxidative stress (measured by plasma oxidized LDL), NAD+ abundance in whole blood, 6-minute walk improvement by baseline whole blood NAD+ levels, and 6-minute walk distance at 4 weeks after intervention completion.

https://clinicaltrials.gov/study/NCT07782671?intr=Nicotinamide%20Riboside&viewType=Card&rank=1

Anyone did Niagen shots during stims?

Did it help you make euploids, or maybe you had some adverse effects?

Thank you for sharing

Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+). Research published by Maussudi et al. 2012 demonstrated that skin NAD+ levels were negatively correlated with age in both males and females, and aged skin was also correlated to an increase in DNA damage. Therefore, it is proposed that supporting skin NAD+ with precursors such as NR may be a strategy to combat DNA damage that leads to undesirable signs of skin aging, thus supporting skin cell resilience. The use of NR as a dietary supplement has produced effective, efficient, and reproducible increases in NAD+ in humans. However, the role of topically applied NR for skin aging requires further investigation.

https://clinicaltrials.gov/study/NCT07774000?intr=Nicotinamide%20Riboside&viewType=Card&rank=1

Would like to try it out but would like the actual input of people who've used it.

The goal of this clinical trial is to learn if orally administered nicotinamide riboside works to slow the progression of early Alzheimer disease in adults.

https://clinicaltrials.gov/study/NCT07741071?intr=Nicotinamide%20Riboside&viewType=Card&rank=1

I've been taking True Niagen NAD+ and NMN supplements for a while, I've also had joint issues for almost my entire life.

Yesterday I had an NAD+ IV and I can already feel the results on my joints, I've never felt this kind of result after taking supplements and I've been taking them for a while. This was also the lower does IV of 250 mg, I will ask them to up it next time.

One NAD+ IV seems much superior to the supplements I've been taking

The goal of this clinical trial is to learn whether Nicotinamide Riboside, a form of Vitamin B3 also known as NR, can improve blood vessel health in the brain, memory, and physical function in eligible study participants. NR is considered investigational for this study because it is not yet established for this specific use.

https://clinicaltrials.gov/study/NCT07703137?intr=Nicotinamide%20Riboside&viewType=Card&rank=1

This study is testing whether a dietary supplement called nicotinamide riboside, (NR), can be used in adults with moderate chronic kidney disease.

https://clinicaltrials.gov/study/NCT07693543?intr=Nicotinamide%20Riboside&viewType=Card&rank=1

I have heard of the oral True Niagen, but now they are selling an injectable form. It is supposed to be superior to NAD+ because it freely passes into the mitochondria and then converts to NAD+. The oral is expensive and there doesn't seem to be a lot of positive user experience. I can't seem to find any information on the injectable. It's crazy expensive at around $300 for 5ml 100mg/ml. Still not sure how expensive that is because I can't find any kind of dosing protocols. Has anyone here tried it?