r/OrganicChemistry

I can’t understand why chloroform isn’t flammable while formic acid is when the carbons have the same oxidation state.

I can’t understand why chloroform isn’t flammable while formic acid is when the carbons have the same oxidation state.

u/1s2_2s1 — 19 hours ago

Chemistry PhD coming from a biosynthesis/natural products background

Hey everyone,

I'm a 3rd year biochemistry undergrad and most of my research experience so far has been in natural products biosynthesis. I've been working on things like enzyme expression/purification, enzymatic assays, and heterologous expression of biosynthetic gene clusters in e.coli/yeast/fungus.

I'm thinking about applying to Chemistry PhD programs, but I'm wondering how much of a disadvantage I'd be at since my background is pretty heavily on the biosynthesis/biochemistry side rather than traditional synthetic chemistry.

I really like chemistry and I'm interested in things like natural product chemistry, chemical biology, biosynthesis, biocatalysis, and potentially synthesis, but I haven't really done the typical undergrad organic synthesis research...

For people who've gone through chemistry PhD admissions, how would a background like this be viewed? Would chemistry departments see natural products/biosynthesis research as relevant chemistry experience, or would they mostly see me as a biochemistry applicant?

Also, would it be worth trying to get some actual synthetic chemistry experience before applying, or would I be better off just continuing to build on my biosynthesis research?

I'd especially appreciate hearing from anyone who came into a chemistry PhD from a biochemistry or biology background. Thanks!

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u/Old-Country-4180 — 18 hours ago

Why does the substituent on the ring matter so much if the negative charge on oxygen can’t delocalize to the ring?

u/1s2_2s1 — 23 hours ago

Meeting CEO of Pfizer

Next week I am meeting the ceo of Pfizer and get to ask his questions, any idea what I should ask him,
I’ll post all answers to good questions I get here,
Thank you :)

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Rotary Evaporator Bump Trap filling slowly

Hello,

I am running experiments with toluene, which I am removing using a rotary evaporator. The bump trap has been filling slowly over hours, and I'm not quite sure why. You can see from the picture that it's just clear/clean toluene, and not a sudden foaming, as the material is black in nature. There's even some toluene stuck at the adapter.

The system is set to 77mbar pressure, and the bath temperature is 60 C. The chiller is set at 2 C due to the lab being pretty warm (around 25 C right now).

Any help would be appreciated. Thank you.

EDIT:
Thank you for all the answers and concerns on the angle.

I was able to fix those concerns by disassembling the system and changing the angle. The operator of the device told me it couldn't be done. Frustrating but at least I learned something!

I have a second bump trap that is larger, and I will wrap it with foil to help insulate it.

I read a few other proper operations tips, which I think may help.

EDIT 2:
We took all the recommendations we could, and tested them today with a volume double the usual size. Time to finish was under an hour compared to 3-4 hours. So, yay! Success! Thanks for all the help (and occasional snark)!

u/Professor-Sorrontis — 2 days ago
▲ 93 r/OrganicChemistry+1 crossposts

No more free ChemSketch

Hi all,

Unfortunately, my full post about this was deleted from this subreddit... So I'll keep this as short as possible so that this doesn't get deleted. Anyway, some of you may like to know that ChemSketch has now officially been killed by Revvity (the owners of ChemDraw who recently bought ACD/Labs, which owned ChemSketch).

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u/SnooCakes6231 — 2 days ago

Starting a channel!

I really love chemistry and helping people who are just starting out. This is NOT me advertising the channel, but rather, I wanted to hear advice from people with a lot of experience.

There may be a few things that aren’t perfect, and there’s only so much I can fit into one video, but I’d really appreciate your support and constructive feedback.

Thank you!

youtu.be
u/Historical-Kiwi-1280 — 2 days ago
▲ 16 r/OrganicChemistry+1 crossposts

IR and H-NMR not matching?!

While in an unknowns lab I took a IR which I initially thought was an aromatic carboxylic acid of some sorts. But then after doing H-NMR I don’t have a carboxylic acid peak but I do have an aldehyde peak. After running some aldehyde tests and ester tests they’re all inconclusive, not a positive but also not an affirmed negative. When testing solubility in NaHCO3 it was soluble and I saw bubbles which pointed towards carboxylic acids again. I’m so lost on what is going on. I’m going to attempt to redo my H-NMR since the machine was acting up but I was curious to hear theories on what might be happening.

u/Judethenotdude — 3 days ago
▲ 7 r/OrganicChemistry+1 crossposts

Advice for finding an organic synthesis postdoc in Europe with a U.S. PhD?

I’m completing my PhD in organic chemistry at the University of Vermont. My research spans target-oriented synthesis and methodology development, particularly the synthesis and Diels–Alder chemistry of 2-N-acylamino-1,3-dienes.

For those who have made a similar move:

  • Is it better to apply to advertised positions or contact PIs directly?
  • How far in advance should I approach groups?
  • Which countries are generally most accessible for an Indian applicant with an American PhD?

P.S.: I speak both French (C1) and German (B2)

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u/yashpunjabi1503 — 2 days ago
▲ 13 r/OrganicChemistry+2 crossposts

Seeking help to mix graphene oxide nanoparticles with soy wax

Hello, a mech eng grad student here! Had problem with dispersing graphene oxide on soy wax, which the graphene oxide wouldnt stick to the wax and instead pools at the bottom. Are there any ways to avoid this problem by using specific method or substance? Thanks in advance!

u/adityaputra2005 — 5 days ago

What's the correct appropiate IUPAC name for this compound?

I have searched both at Chatgpt and gemini. They give both answer as appropiate IUPAC name
(2-methylpropyl)benzene)
2-methyl-1-phenylpropane

But in absense of fg and multiple bond in chains outside the benzene then benzene is treated as parent chain, that's the IUPAC rule my sir has given

so according to it (2-methylpropyl)benzene) should be correct one

Am i right ????

u/Fickle-Break2862 — 7 days ago
▲ 16 r/OrganicChemistry+2 crossposts

Need help for synthesis

I need to prepare the acid chloride from my carboxylic acid and then perform a coupling reaction with glycine to synthesize the corresponding hippuric acid derivative. I am looking for the simplest and most reliable method that can be successfully carried out in a laboratory.

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u/SignalClimate9897 — 6 days ago