How can compounds ever make it into a binding site if they are constantly in the wrong conformation?

How can compounds ever make it into a binding site if they are constantly in the wrong conformation?

u/1s2_2s1 — 11 days ago

Pyramidalized carbocations?

In line with my post from the other day about a flattened carbanion (https://www.reddit.com/r/OrganicChemistry/s/77lyABSpHb), I wanted to find an example of a pyramidalized carbocation to discuss. I could not find a good example. At least, I could not find an example where the electronic features of the substituents cause pyrimidalization like the CF3 groups caused flattening. There are probably examples like bridgehead carbocations that are pyramidalized. Can you think of other ways to force a pyramidalized carbocation? (Also be very careful with AI with these types of questions. It literally makes stuff up)

u/1s2_2s1 — 1 month ago

When you have a solid salt with a polyatomic cation like an ammonium, what does the anion actually bind to?

u/1s2_2s1 — 1 month ago

If molecular motion is related to temperature, is there a maximum temperature because nothing with mass can move at the speed of light

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u/1s2_2s1 — 1 month ago
▲ 333 r/chemistry

How do molecules manage to react when it seems they are way more likely to collide in the wrong orientation than the right one?

u/1s2_2s1 — 1 month ago

What is the size of H+? Is it the size of a proton. It seems like it should be bigger, but it has no electrons.

u/1s2_2s1 — 1 month ago

I see a good benzylic leaving group. Why don’t you see things like benzalkonium chlorides undergo SN2?

u/1s2_2s1 — 2 months ago
▲ 167 r/OrganicChemistry+1 crossposts

I saw this structure today and wondered. Which nitrogen is the most basic?

u/1s2_2s1 — 2 months ago

Is Spider-man’s webbing physically possible?

Could a material take up so little space so as not to affect his appearance and then be projected from his wrists expanding exponentially? Could said material weigh so little so as not to affect spider-man while also possessing the tensile strengths to hold so much mass? Wouldn’t such a material become a pain for normal humans to clean up. Is this material possible?

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u/1s2_2s1 — 2 months ago
▲ 219 r/chemistry

What’s with all of the misinformation about aspartame being bad for you? Isn’t it just a dipeptide? Isn’t the human body built to deal with this class of molecules?

u/1s2_2s1 — 2 months ago

In my neighborhood there’s a lot of obnoxiously loud sports cars. My question is, is all that energy going toward making all that racket wasted energy that could be used to actually make the car go faster?

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u/1s2_2s1 — 2 months ago