I have POI- wondering if anyone had success using Estrace as priming and clomid. I have afc 1-2 at baseline, but follicles do not grow. Looking for advice to see if clomid or letrozole would be a good option for me try.
I’m 37 and very confused about my hormone results and possible POI/perimenopause. I’d really appreciate hearing other people’s experiences.
I had a hormonal IUD for about 15 years (with replacements in between) and had my youngest child 10 years ago. I always still had light but regular periods. In 2024 my cycle became less predictable, and in early 2025 everything changed. I suddenly bled for 4 weeks straight, then stopped for a week, then bled again for 2 weeks. It kept changing: light pink, then very heavy with clots, then dark red. After that, my periods stopped completely for the last 10 months.
During this time I became extremely exhausted and felt unlike myself. I had insomnia, hot flashes, muscle pain, felt emotionally flat, overstimulated, disconnected, and couldn’t enjoy things anymore. I also have ADHD and this felt very different from “normal” burnout or stress.
In January my doctor ordered an ultrasound because I had pain during sex. It showed my IUD was sitting low, so it was removed. Since I still had no period, we waited 3 months to see if my cycle would return.
Last week I asked for more blood tests because I still felt awful.
First results:
FSH: 62.30
LH: 32
Estradiol: 72
My doctor discussed it with a gynecologist and said because of my symptoms I can already start estrogen patches after repeat bloodwork.
Second results 6 days later:
FSH: 66.70
Estradiol: 196
Now I’m confused because my estradiol suddenly seems more “normal,” and Google is making me anxious. Does this still sound like POI/perimenopause? Can hormone levels fluctuate this much? We still have a child wish, so this is emotionally very hard.
Has anyone had similar blood results or symptoms?
I have primary ovarian insufficiency and was diagnosed very young. I’ve never had a FSH score under 100. I’ve been seeking fertility treatments but am consistently told only donor eggs would work for me. This is probably true. I can’t find much information that settles well with me about the donor egg process. I can’t find many people with my FSH level and diagnosis timeframe that have successfully conceived. I’m not sure if anyone here has any insight but I would love to hear.
I’m trying estrogen cream compounded in ellage base externally only. I’m kinda red and mildly itchy. Is this irritation or can this cream cause a yeast infection? I thought estrogen cream in ellage base was the best option, but are the vaginal tablets better?
I was diagnosed with POI very suddenly at age 32, and at 38 was diagnosed with hashimotos (by accident, no symptoms). Has anyone discovered the "link" between POI and hashis? No one has said specifically whether the POI is its own autoimmune condition, or perhaps more of a byproduct of hashis. I've been working with a naturopath on the hashis, but antibodies seem to keep ticking up, oddly, the more I try to do for it. I'm on HRT for the POI and am hoping it has some immune-modulating effect but am not sure. Would love to hear anyone else's experience with these two conditions.