r/dupixent

I’m going to be traveling to a hot place it’s on average 98 degrees and friends want to stop along the way in between accommodations and I worry leaving the dupixent in the car for long hours will get too hot. I’m going to bring a small cooler and ice packs, however, not sure if that will last long if the car gets really hot. Anyone else have experience with this and any suggestions?

The title may seem controversial but I’m genuinely curious. I just watched a video stating they’re doing studies on how G1LPs can help with inflammation. I saw in the comments someone said they’re completely off their steroids since taking a G1LP. I was curious if anyone in this sub is either taking both, stopped taking one over the other, etc. I’m currently off Dupixent (not exactly by choice, we had decided to grow our family and this sub helped me decide to stop taking it while trying/pregnant so thank you to those who were honest with your experiences) but I am waiting for the day I can start again since it helped me so much with my sinus and lung issues. I’m wondering if a G1LP is something to consider trying before going back to Dupixent due to the price difference.

Hello everyone,

My son has been on monthly dupixent (syringe) since he was 6mo for moderate - severe eczema. It is great to be honest, he does get flares here and there but no where near how he used to.

However, he has developed such a strong phobia of medical settings and anyone wearing scrubs.

It’s gotten progressively worse the last few months. He was recently really sick and we took him to ED. He is so terrified. He would scream when the nurses would try to check his temp, weight him, the doctors couldn’t listen to his chest let alone swab him. They couldn’t physically assess him at all.

Not to mention he turns blue because he’s screaming and fighting so badly whilst being restrained during the injection.

The doctor suggested we look into getting him some OT which I have booked in.

We are considering taking him off the medication so he isn’t terrified of health care for the rest of his life.

Any parents go through this? Anyone have experience taking their child off Dupixent?

Thank you in advance 🫶🏻

I only just started dupixent in march and now experiencing my first power outage with it in my fridge. What does everyone do during a power outage if you don’t have a generator? How long realistically can it sit in the fridge with the power off if I keep the fridge closed? Also how do people monitor their fridge temperatures on a regular basis? I’m probably overthinking this but just got my next two shots delivered and this medication is expensive! So it can’t be out of the fridge for 14 days.

Edit: Good news. power has been restored!

Hi there! I've been taking Dupixent 300mg autopen every other week since August 2025, prescribed by my dermatologist for chronic urticaria after months of trying to manage it with antihistamines and even singulair (that one did not go well). Though I also have an EoE diagnosis where the dosage is usually once weekly, I take it every other week because it is prescribed and managed by my derm for urticaria. (Though last year she initially filed it under atopic dermatitis because she was worried I would be denied for CSU, since the FDA-approval for it was so new. She's since changed it to CSU, though, to prepare for what's going on below.)

DOSING BACKGROUND AND CONUNDRUM: Anyway, at first, the dupixent combined with the 40mg cetirizine was very effective for my hives. However, after a few months, they started breaking through again (which I have been told by someone off-the-record is somewhat common in refractory cases), until finally late this May it was quite bad again and I wasn't willing to keep existing like that. Therefore, my dermatologist put me on an 8-week off-label trial of 300mg once weekly, using samples from her office. While I am still having breakthroughs starting on day 4 after each injection, they are significantly reduced on this once weekly protocol (and no longer create huge plaques over massive planes of my body, which I consider a win). I see my dermatologist for a check-in on Monday and we will discuss whether to try to get insurance approval for 300mg once weekly under the CSU diagnosis.... Unfortunately, because my EGD showed my EoE is in histological remission right now (yay! I'm also on a strict allergy diet for 3 of the 6 most common EoE triggers), my GI isn't willing to prescribe it once weekly, which I understand.

THE QUESTIONS: Has anyone had luck getting Dupixent prescribed more frequently than recommended for their condition, or off-label? Regarding insurance, and the Dupixent My Way program? What does it take? I'm afraid my insurance is going to take ages or deny it, and then I'll start losing my "steady state" concentration and be back to (or worse than) where I started. What's the liklihood of them approving it? I'm in the USA.

^(Because I'm also trying to get into a clinical trial right now (though I'm not optimistic as its been nearly 2 months since my first call)), ^(I'm trying to put off switching to Xolair or Rhapsido so I remain "naive" to some of the heavy-hitters to improve my chance of selection. But if insurance won't approve the 300mg once weekly, I don't know what else I am supposed to do.))

Thanks for any thoughts you have, or any experiences you may be able to share!

We all know that the Dupixent auto-injector pen hurts. Does anyone else have experience with some injections hurting significantly more than others, though? Some injections it's fine, just the usual pain from the pressure thanks to how fast the pen injects the meds. But some injections hurt like CRAZY the moment the needle goes in and I can't hold it on for even a second.

I'm always consistent with my method - I set the pen out at room temp for several hours, I inject in the abdomen at least two inches away from the navel, and generally lower down on the abdomen than the navel. I make sure I switch between the left and right side of my abdomen every injection.

So, I'm stumped as to what could be causing the excess pain. Any ideas?

Hi all! I’m back on dupixent after going off for about a year due to insurance battles. I’m so glad to be back on, but after 3 doses it feels like the pain is worse compared to past injections. I use the auto injector in my thigh, because my medicine is normally administered by someone else. I have the same feeling in my stomach the few times I’ve done it there.

I follow all the tips— I let it warm up on the counter for a few hours, then put it in a pocket or hold for 30-60 minutes to get it up to body temp. I’ve tried ice at the injection site, which is more hassle than it’s worth imo.

The needle itself is fine. I don’t mind normal injections or vaccines, and I have a fair number of tattoos. What really gets me is the stinging/burning of the medication going in. Is this just a suck it up kind of situation, or does anyone have any tips to make that sensation a little more manageable?

Ive been on dupixent for almost 3 years and after years of swelling and pain with doing thigh injections my dermatologist suggested I try stomach injections (I was always too scared to) it has been so much better! HOWEVER I notice it hurts in my stomach way more on my right side than the left. Has anyone else noticed that? Whenever I do it on the right side the pain feels sharper and the area is more sensitive after.. also do you need to switch sides like you do with the thighs? Im wondering if I can do left side everytime

I had the loading dose today and was TERRIFIED of the pain from all the videos and posts I’ve seen. I can’t stress enough—it was a 1 in a 10 point scale. No more painful than a Covid vaccine or a flu shot. I’m not saying it’s the same for everyone, but just wanted to share a positive experience. I was sooo psyched out and it was totally easy!

I’ve had eczema my whole life but these past 2 years have been pretty bad. I tried dupixent and got horrible facial flares after the first shot. It got significantly worse throughout the 8 weeks I was on it until I stopped. The dr wanted me to push through but I couldn’t because of upcoming trips etc. After coming off dupixent, my face never resorted back to how it used to be. Because of this I’ve used Elidel and opzelura but now feel pretty dependent on them :/ (I know not good).

I’m looking to start Ebglyss because I need some control. I was hoping to hear success stories from someone similar to me. My body is pretty manageable but I do have eczema on my hands, neck, arms. I don’t care about clearing my body as much, really just my face. I’m praying that Ebglyss can help me control to where I don’t need Opzelura every other night & im also hoping I wont fail it like I did dupixent.

Any hope for me?

So I started dupixent today for allergic asthma and nasal polyps (yay!) I had my first dose administered at my allergist’s, by a nurse. before the injection I asked her if we should be doing the loading dose as I had been told we would be doing two injections by CVS and everything i’ve read.

She told me she had never heard of a loading dose and scoffed at the idea??? so I only got one injection. will this make it take longer for me to see any benefits? Is it common to not do a loading dose?

Hello friends! I’ve been in the comments here for the past 2 years on and off sharing my eczema story, and I thought I’d share some updates, as well as tips and tricks I’ve found to help me for anyone who has recently been dealing with this, or has loved ones dealing with this.

Life summary: severe eczema my whole life (f22). As a child, open eczema wounds led to a staph infection turned septic osteomyelitis. I was on allergy shots (immunotherapy) between 7-14 which cleared my skin, but eczema came back with a vengeance when I was 20. Did full course of oral and topical steroids, which nearly developed into TSW. I was on Dupixent biweekly, but got switched to weekly due to ongoing flares.

1. Being on Dupixent weekly is very painful. I have a low body fat percentage, so not a whole lot of skin to squeeze when I inject. Dupixent can be taken out of the fridge for up to a week before using — I take it out a day or two in advance, this significantly helps with injection pains.
2. Skin afflicted with eczema is *fundamentally* different. Our skin cells are ‘further’ apart — think of skin cells as a brick wall, the cells being the bricks and lipids being the mortar. Our ‘mortar’ is the issue, we lack strong lipids in our skin which cause major moisture retention issues. This allows irritants of all sorts to easily pass through our skin, BACTERIA INCLUDED. Let me be a cautionary tale.
3. See point above, staph colonizes our skin as a primary bacteria. I’ve seen posts saying to treat eczema as a staph infection, and many of the tips are very helpful — SkinSmart eczema spray works very well for day to day maintenance, and hibiclens soap is great for a biweekly skin ‘reset’ for me. I haven’t needed to use hibiclens since I haven’t flared in months (knock on wood), but use very sparingly since it is a medical grade antibacterial wash. Implement little things as such to prevent infections as much as you can.
4. Point above AGAIN. I’m on Dupixent because JAK inhibitor medications such as rinvoq and opzelura have increased risk of infections as a side effect. That doesn’t mean don’t go on them, but biologics, at least to me, feel safer.
5. Basic, but moisturize within 5 minutes post bath or shower. My skin can now tolerate scented products, but Vaseline works great for me (if sensitive to lanolin and sheep byproducts, do NOT use aquaphor). I also really like Eucerin’s baby eczema lotion. It’s an ultra thick formula, so very good for cold months.
6. It can be, but it is NOT always a diet issue. I have celiacs, so trust, I’ve *been* off of gluten. My long term boyfriend has a dairy allergy, so I rarely eat dairy when we cook together, and just don’t eat a ton of dairy in general. Elimination diets can work, cutting out excess sugar has been helpful for me since Dupixent can cause fungal sensitivities (and fungus thrives on sugar!), but eczema isnt inherently a diet or gut health issue. Again, it can be, but my diet had no part in how severe my eczema is.
7. Get sunlight (safely) if able. Go to a pool! Chlorine actually helps my skin a lot, which is why bleach baths (putting a capful of bleach into a full tub, it dilutes the bleach enough) are recommended.
8. Dont ignore your mental health — stress can flare eczema, but eczema can cause depression, anxiety, loss of sleep, lack of focus, etc. Take care of yourself, and remember ultimately that your skin does not define you.

**EDIT**

9. I’ve noticed that I flare about once a month, always on my period. Definitely not as bad as they were pre-Dupixent, but I get perioral dermatitis every menstruation. Going on birth control has helped, but hasn’t fixed it fully!

10. Thyroid issues can be common triggers for eczema as well. Hashimotos and Graves both run in my family, however I’ve recently gotten my thyroid checked and haven’t gotten any results indicating of issues personally — but, this link has been proven.

11. If you have a child struggling with eczema, EMPOWER THEM! Teach them that kids may be mean, but kids don’t understand — I got bullied as a child, getting called ‘contagious’ or ‘diseased’. This anxiety of other people perceiving me horribly led to isolation as an adult when the flares came back, but looking back on it, the isolation was not worth it. Regardless of any skin condition, you (or your child) must learn self acceptance and self love!!!

The struggle is real, I pray every day modern medicine advances enough to find a cure to this!!!

So I’m in my 20s now and I have had eczema since I was a baby and it’s moderate-severe case and I’ve just been approved for Dupixent on the nhs but it’s probably irrational but I have heard a few concerns of people, having facial flares and I have had a history of facial eczema, as well as some people experiencing hair loss/alopecia and ctcl I haven’t fully read the literature but I’m worried since I have had my eczema my whole life and I’d rather deal with that than any long term dangerous/ unpleasant side effects, I guess it’s a case of the devil you know being better than the one you don’t, I also have nasal polyps and allergies which I have heard it helps with. TLDR essentially I’m wondering about people’s experiences with Dupixent positive and negative, to gauge whether I should try it or not I most likely will but I guess im apprehensive, also for the common side effects are there any ways of curbing these and when are you most likely to experience side effects and how have long term users found it do you find that it still works well or the incidence of side effects increases over time? Sorry for the spiel would be greatly appreciative of any advice, pointers or information.

I started dupixent 5 weeks ago today. 4 injections so far. Since then it has been working okay for my whole body but hasn't reduced the itchy yet. I'm also tapering ciclosporin.

I really believed once I'd start I'd see immediate results based on what others have said. I'm currently having a full body flare and the itch has been at its worst in a year. My dermatologist has prescribed topical steroids for me to use to keep it under control but I was wondering, does anyone still rely on steroids for persistent eczema patches?

TL;DR, it worked for me and if you're considering it, it might be your saviour.

Long story:

So I was born with eczema, everywhere. My arms, legs, thighs, necks, face, hands, feet. Growing up it was a visible issue but it was just something I lived with. As painful as it was, I was just used to going to bed with my thighs all itchy and oozing of oil from the scratching.

However, everything changed when my father passed away right before I turned 16. That's when things got 10x worse, and every single day, a psycho episode of scratching would occur. My face was discoloured, my hands were covered in scabs, my arms were red patched, even my feed were red. I tried triamcinolone for a night, but my mother took it away as she wanted a more natural approach. I should mention that my mother blamed my eczema on my food habits, which sure could help improve your skin but it doesn't cure eczema. She refused to let me see a dermatologist for this.

It's not until the following summer when I was 16 when I was just, ALL RED, from neck to feet, and my fave discoloured and she walked in on me moistuizing with aquaphor after the shower that she finally caved in and let me see someone. Instead of the dermatologist though, she took me to an allergist instead where he told me about dupixent. My mother wasn't happy, but after seeing me in that state she was finally willing to let it try, but we ended up waiting till the next visit to "think it over" as in, she thought it over. However, in the mean time my allergist got me a tub of triamcinolone which was great. It helped wonders.

I got dupixent, and the following day, for the first time in ages I wasn't scratching every moment. The healing process took about a month, but my body finally was looking less discoloured, and I wasn't in pain every time I moved.

It's kinda like this. The dupixent helped me stop scratching, it didn't fix the already red on my skin though. The triamcinolone is what made my skin not red anymore and helped it's healing.

While dupixent was supposed to be taken every 2 weeks, I took it every 3-4 months when I noticed my eczema was coming back. I did this for about a year and a half, until I turned 18. Nowadays, I just use triamcinolone every now and again for when I have a flare.

From what I saw, my father's death turned my already problematic eczema cycle, into a much more viscous one that ate me alive. The Dupixent halted that cycle, and over the course of a year and a half to two years, allowed my immune system to return back to the old cycle, or even less of that.

Don't get me wrong, I'm 20, nearly 21 now and my eczema is still present but it's a 10x less than what I dealt with when I was 16. And it's arguably less worse than even before I was 16. I still have some episodes every now and then, but you should still be on top of your skin regardless if you have eczema or on treatment. So at this point, my life is basically pretty normal. I can what I like within reasonable moderation. I keep lotion near me at all times just like anyone else with eczema, and I always have some steroid handy. So things are pretty typical now.

If you're considering taking Dupixent, just know that it doesn't "cure" you, it holds you off until the drug metabolizes out of your body, if that takes two weeks to 3 months depending on who you are. It can be a MASSIVE game changer to a lot of people. That, and maybe if you're lucky, your immune system might change after a while taking it. Don't bet on it, though.

That and taking Dupixent? Just brace yourself. That shot hurts like a bee-sting. It hurts noticibly more than regular ones, but it's a small price for salvation trust me. My advice is use the syringe over the pen, tho a lot of people might disagree with me on that.

Triamcinolone is also a big game changer for me, though I would usually recommend taking that at night cuz when I took steroids in the day, I would scratch it off. At least before I sleep, the steroid is on me for about 7-8 hours before I wake up and start scratching again. Don't over do it, and try not to become reliant on it because no one wants TSW. Also don't use it on your face.

Anywho, I hope my experience was worth reading. Hopefully it give anyone considering taking it, a little bit of insight on what to expect.

Good luck guys. Eat healthy, avoid junk food, moisturize every night, don't make the shower to hot. God loves y'all!!

Hi everyone.

I suffered from severe eczema and dupixent saved me for 1 and half year.

But, some weeks ago (~5w) I experienced heavy headaches with my right eye in pain.

My right eye was not red, it felt dry (sometimes itchy) my sight was a bit blurry at first.

I wasn't able to read and if I try it caused Instant headaches.

Today my eye isn't blurry anymore but I still have trouble. My right eye's image is very slightly darker and the colour is not the same as the left eye either. (blue/red difference, but not always visible)

It's not a big difference, I needed 3 weeks to really tell what is wrong and I'm not sure yet today. But it bothers me because I feel like I have difficulty seeing properly (it's worse with fatigue)

I already have seen 2 different ophthalmologists that found nothing, even with a retinal scan and think my eye sight is good. But it really bother me. And I don't want it to worsen.

My dermatologist doesn't know what to do since other doctors don't find anything.

Forecasting to see a third ophthalmologist.

I'm thinking of stopping dupixent, but don't want eczema back all over my body. Any advice or similar experience? Should I stop the drugs? I'm very worried about this situation.

Thanks for your advices.

edit : I said both found nothing, but it's not totally true, the first doctor said I have dry eyes. And give me drops. It slightly relief the dryness, but I don't see any other enhancements

We have maxed out all our options. We had the copay card/virtual debit card, we've called our insurance, we've applied for a hardship application, I spent four hours on the phone and feel like I got no where.

Our next steps is to call our sons doctor.

Background: My son started dupixent 1.5 years ago, so we were covered for 6 months June-December 2025, then this year Jan-June. Now it's 932$ to get it shipped. We currently only do one shot a month so the remainder of the year is 3k and we simply can't afford it. If we have to we will go in debt because it's changed my son's life.

We tried all the creams, and diets, did bleach baths and wet wraps, he was miserable. We got a doctors note so the school nurse could apply his cream during the day etc

The shot is the only thing that had consistently worked but due to him growing our doctor suggested upping his shot to every 2 weeks.

Due to us being worried about the coverage we didn't do it yet but it's obvious he needs it as is skin condition is getting worse and I know we just can't afford it and I am heartbroken.

Obviously the first step is that I'll talk to his doctor but does anyone else have any experience with financial assistance?

I'm also curious to know about alternatives in case we need to take it into consideration. He's currently 6 years old.

I think im destined to live with my eczema forever. This is week 15 and my eczema hasnt improved. In fact, after i take my shot the next 5-6 days my arms are dryer and itchier. The week I dont inject i start to go back to normal and then it repeats itself. I think im just not destined to have clear skin!

Hi everyone!

I’m currently 38 weeks pregnancy with my first baby and have had really bad hand dermatitis, especially during the 3rd trimester. I originally developed it in January of 2025 and was put on a JAK inhibitor cream (Opzelura) that worked really well. Once I got pregnant I was advised to stop using is so I haven’t touched it since November of last year. I was able to manage my dermatitis during the 1st and 2nd trimesters, but the 3rd has been unbearable. My hands are flaky, painful, red, and sensitive to the touch. I’ve used my fair share of cortisone creams and was recently just seen by my dermatologist who recommended starting Dupixent. I also just got a biopsy done to see if we can figure out what may be the underlying cause of the dermatitis. Has anyone in this group been put on Dupixent during pregnancy? I’m debating on starting it, but am extremely hesitant at the moment.