u/Able-Shirt3501

Curious if anyone here has started researching MF-300 which is a 15-PGDH inhibitor so it counters age related decline of PGDH and thus increases regenerative signaling involved in muscle, stem-cell activity and tissue repair. Think “counter to anabolic resistance” in aging population (me sadly).

This has already progressed through clinal phase 1 trials, including testing in older adults, with reported target engagement and favorable tolerability. Development is now moving toward Phase 2b for sarcopenia.

The research compound is available through chemical suppliers but I find no research community engagement.

Is anyone researching? I’d be particularly interested in what you’ve found regarding sourcing/testing, pharmacokinetics, research protocols, or anything else that isn’t obvious from the published development data.

Wow - Reddit decided that “back pain”’was the wrong chat group to post a chat on back pain and pushed it here as if I am talking about bones. This will not be helpful but here you go

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I have an ugly MRI with severe foramen stenosis at l5/l4 and l5/s1 with facet arthritis and end plate modic changes all due to mostly collapsed discs at the end of the lumbar. Pretty common stuff for this forum 😂.

I sort of really put it on the ropes almost 2 years ago doing seated leg presses. Got tickle deep in the lower back and it all eventually turned into chronic s1 nerve irritation and a daily stiff back that no longer calms with a good hike. So i am really on the borderline. Still very functional but also in some pain daily and need that 10mg amitriptyline to sleep through the night.

I have been trying everything. First I tried to lose some weight and see if that tipped things in my favor. So I tried tirzepatide and lost about 7% of my body weight but my back got noticeably worse. After trying to reason why, i got the theory that i lost critical muscle that gave me the girdle protecting the back.

So i switched efforts to strengthen myself. I am near 60 so started enclomiphene to improve my hormones to aid in the effort. As it turns out it did raise my testosterone and estradiol but my free testosterone was unchanged and yet My back felt noticeably better. I stopped the enclomiphene and back pain got worse. I started it again and better. I upped my dose and really feeling good now. It might be the estrogen improving my fluid balance. It may be the bound testosterone that will still act as an anti inflammatory. It could be that I gained weight and muscle and improved the protective girdle. I am just sharing because it worked. Its not all about muscle but for me is about having more hormones that is working better than any prp or ESI.

I have an ugly MRI with severe foramen stenosis at l5/l4 and l5/s1 with facet arthritis and end plate modic changes all due to mostly collapsed discs at the end of the lumbar. Pretty common stuff for this forum 😂.

I sort of really put it on the ropes almost 2 years ago doing seated leg presses. Got tickle deep in the lower back and it all eventually turned into chronic s1 nerve irritation and a daily stiff back that no longer calms with a good hike. So i am really on the borderline. Still very functional but also in some pain daily and need that 10mg amitriptyline to sleep through the night.

I have been trying everything. First I tried to lose some weight and see if that tipped things in my favor. So I tried tirzepatide and lost about 7% of my body weight but my back got noticeably worse. After trying to reason why, i got the theory that i lost critical muscle that gave me the girdle protecting the back.

So i switched efforts to strengthen myself. I am near 60 so started enclomiphene to improve my hormones to aid in the effort. As it turns out it did raise my testosterone and estradiol but my free testosterone was unchanged and yet My back felt noticeably better. I stopped the enclomiphene and back pain got worse. I started it again and better. I upped my dose and really feeling good now. It might be the estrogen improving my fluid balance. It may be the bound testosterone that will still act as an anti inflammatory. It could be that I gained weight and muscle and improved the protective girdle. I am just sharing because it worked. Its not all about muscle but for me is about having more hormones that is working better than any prp or ESI.

I remember so many accounts of NFL players retiring and then needing back surgery within a couple years. Makes one realize how important back muscle strength is to hiding a bad degenerating spine.

For myself I have noticed that it hurts to hike but if I don’t hike, I spiral down to a worse place. I was researching ways to hit these stabilizing back muscles without loading the spine. The Stuart McGill “big 3” are obviously key but was looking into high intensity focused electromagnetic (HIFEM) solutions that can hit these muscles hard including the pelvic floor.

In any event I am taking the HIFEM plunge and will share if it works. In the meantime, has anyone else tried this and seen benefit?

Thanks

This one is slipping through the cracks and does not get the attention it deserves. Up regulates klotho (longevity), up regulates cAMP, and normalizes TNF-alpha (reduces inflammaging). This benefit is achieved with 1 pill a day versus the 3 pill a day for micro vascular benefits.

I started taking one 400mg slow release tablet a day. I am in my 3 month. I have experienced zero side effects. No GI issues. No jitters. Nothing. I still drink my coffee as normal.

Anyone else?