r/Biohacking

Have lost 100lbs officially with plans to aim for 35 to 40lbs more. Started at 340 in the starting picture, currently at 240lbs as of today. Have tried a few other peptides during the journey, mainly KLOW and MT2 with good results. I do not count calories, I only aim for a protein goal then just eat healthier now as a result overall. Starting picture was November 2025, so progress has been over 9-10 months. Would like to be closer to 200lbs by end of year. TRT dose is 175mg a week, I do my shot every other day, Reta is sitting at a split dose every Tuesday/Friday with each shot being 5mg as of now. Started Reta low and titrated up and have been coasting on my current doses.

Photo 1: 2018 NO peptides, minimal training, drinking alcohol (125lbs)
Photo 2: 2024: initial fat loss after starting (110lbs)
Photo 3: 2026: rebuilt muscle while staying lean and maintaining BW (107lbs)
Photo 4: couple of days ago, feeling strong, lean and jacked (110lbs)

Any tips on losing the last bits of love handle and lower back fat would be greatly appreciated

Started at 264lbs guy. I’m at 200lbs today on reta. I have been working out as well. It feels so good to be in a better shape. Even people treat you differently.
If you just started your journey. Keep going!

We’ve lost a combined 91 lbs since January
Mom on Reta - ↓ 37 lbs
Son on Reta+TRT- ↓ 54 lbs
Both tracking our macros and working out

I saw that last pic of Tom Holland from the latest Spiderman movie making the rounds and thought to myself, Hey, I don’t look too far from that!

The first pic is from May 2025, started Zepbound in June of 2025 at 250 pounds, forced to switch to Wegovy in March 2026 for insurance reasons at 167 pounds and ended up gaining about five pounds on it and hated it. Went to compounded Tirzepatide in early June and back down to 160 now which is very close to my final number I think. I’m almost 47 years old BTW so Tom is quite a bit younger 🤣

If anyone is interested, I’m not on any TRT, my supplements are a daily multivitamin and vitamin D3 + K2 in the morning and ashwaganda KSM-66 and Magnesium Glycinate in the evenings.

I do bust my butt working out 6 days a week with a very light Elliptical session in the mornings 4 days a week with strength training on those days in the evenings. 2 days a week I do one of the P90X Ab ripper routines in the morning and run 4 miles later in the day. I take one day a week completely off from exercise.

Hoping I can maintain this on about 2.5mg a week and switch back to official Zepbound when Caremark adds it back in October but currently in about 6mg a week compounded and will start to titrate down soon hoping to land on that 2.5.

Anxious for no real reason but here we are.

48 years old, started at the end of July 2025, second pic is exactly 12 months and 14 days later. Down 35kg total and actually put on a bit of muscle in the process which I honestly didn't expect.

Dosing:

• July-Nov: started at 2mg, went up pretty slow, didn't hit 4mg until around week 16
• Dec onwards: sat at 4mg for a while, bumped to 6mg around February and that's where I've stayed
• Titrated slow on purpose bc I read too many horror stories about nausea and wanted to actually stick with it long term

Training:

Nothing fancy, just consistent. 4 days a week lifting (upper/lower split), started adding in incline walks around month 3 once the energy came back. Added actual running in December, could not even do 1km without stopping in November, ran my first proper continuous 5k in March in just under 30 min. Ridiculously proud of that tbh, more than the number on the scale honestly.

Food:

Started around 1600-1700kcal which was rough the first few weeks (side effects + deficit combo is not fun). Once appetite suppression kicked in properly it got way easier to sit there without white-knuckling it. Slowly brought it up to around 2000-2200 as activity increased.

Side effects:

Fatigue was the worst part for me, especially first 2 months. Some constipation early on, nothing crazy. Got bloodtests done at start and around month 9 nothing concerning, doc was happy with them.

Where I'm at now: dropped down to a lower maintenance dose just to hold where I'm at while I focus on building the running up and not losing more muscle. Eating closer to maintenance now too.

Thanks for reading, ask away if you've got questions, happy to answer whatever.

SW: 224 lbs

CW: 124 lbs

Age: 21

I started at 1 weekly and slowly worked my way up to 7.

The food noise really disappeared, which was a big thing for me. I stopped overeating, especially when it came to things like ice cream.

I’ve been working out 3x a week and doing cardio as well. I usually do at least 30 minutes of incline walking on the treadmill every time I go to the gym. Getting 10k steps a day has also become much easier as I’ve been trying to make this an actual lifestyle change.

When I first started, I was honestly afraid that I wouldn’t be able to stick with it. I was worried it would just be one of those moments where I thought, “Okay, I want to lose weight,” and then eventually gave up.

But I’m still here, and I’m still maintaining the lifestyle I built.

If anybody is afraid to start or keeps doubting themselves, just take that first step. You don’t have to have everything figured out from the beginning.

If you have any questions, feel free to ask! I’ll be happy to share my experience and help if I can :)

Hi everyone, looking for advice on whether to run Reta or Tesa, or both at the same time.

I’m 5’9 175lbs. I like to be in the range of 170-175lbs so I’m not necessarily looking to shed a ton of weight.

Always been athletic/worked out. However I’ve been battling a major shoulder injury for about 6 months so my workouts have been impacted. I’m having trouble getting rid of the belly fat. I’m looking for any advice on utilizing reta or tesa. I am taking the wolverine mix for my shoulder as well if that makes any difference. My sleep/recovery has never been great which is why I was leaning more towards tesa.

Thanks for your input and I hope I provided enough background for your helpful input.

Edit: Thank you for all the input so far. I I am tracking macros, working out 2-5x a week (I travel for work so its hard to get into the gym some days). To clarify, im not trying to necessarily lose weight (having some assistance with food noise would be nice), im more looking for some assistance toning up my gut and love handles. I did do bloodwork before considering all of this.

I wanted to share my weight-loss journey because I know there are probably people here who are where I was not too long ago.
At my heaviest, I was 340 lbs.
I eventually got serious about changing my life and was able to lose 45 lbs naturally, bringing me down to around 295 lbs before I ever added retatrutide.
From there, I’ve continued the journey and I’m currently sitting around 245 lbs — 95 lbs down from my highest weight.
But honestly, the biggest change wasn’t the number on the scale.
I had to learn how to actually diet.
I had to learn what calories were, how to calculate macros, how much protein I actually needed, how to weigh and track my food, how to meal prep, and probably most importantly, how to be consistent when I didn’t feel like doing it.
There were plenty of days where I didn’t want to train. Days where I wanted to eat whatever I wanted. Days where the scale didn’t move and I wondered if what I was doing was even working.
I kept going.
I also started taking my training much more seriously. I’m in the gym 4–5 days a week, getting my steps in, doing cardio, and working toward building an actual bodybuilding physique rather than simply trying to become “smaller.”
That mindset shift has made a huge difference.
I’m not chasing a temporary diet anymore. I’m trying to build a completely different lifestyle.
340 → 295 naturally → 245 today.
95 pounds gone.
And somehow, I’m more motivated now than I was when I started.
I still have a long way to go, but I’m proud of how far I’ve come. The weight loss is cool, but learning discipline, nutrition, consistency, and what I’m actually capable of has been the real transformation.
If you’re at the beginning of your journey right now, don’t underestimate what can happen if you just keep stacking good days.
I’m not finished yet. 💪

So I went from about the weight I am in my current picture (the skinnier one) to around 180 lbs, then life happened and I eventually went back up to the weight in the heavier picture. That picture was actually taken about 3 weeks ago.

I’ll share some pictures of how I looked before and after my first cut, which I did completely naturally without any enhancers.

What’s pretty crazy to me is that I haven’t really been paying attention to the scale this time. About a month and a half ago, I weighed myself on a Publix scale and saw around 260 lbs. That was basically the point where I decided it was time to lock in.

Right now I’m eating around 1,600–2,000 calories a day and getting about 140g of protein. I know 140g probably isn’t ideal for my current weight, but it works for me and I’ve been able to stick with it.

I also work as a utility locator, so I’m walking around 15–20k steps a day, which definitely helps.

For breakfast, usually around 7–8 AM, I’ll grab one of those cold sandwiches from RaceTrac. They’re usually around 28–35g of protein, and honestly they keep me full for a LONG time. The furthest I’ve pushed lunch was around 4 PM.

For lunch, I’ll usually get a Chipotle bowl, or a burrito if I’m feeling a little hungrier.

Dinner is usually 4 boiled eggs, or occasionally steak or chicken. I definitely need to start cooking more though 😂 I know I’m being lazy with that.
I’m still figuring everything out, but seeing the progress has been crazy. And honestly, reta has been a life changer for me.

Compared to my first cut, reta has honestly made this so much easier. The first time I cut, I did it completely naturally with no enhancers and still managed to lose around 50 pounds in 4 months. So I know I’m capable of doing it without anything, but this time around the process has felt so much easier and more manageable. It’s honestly crazy seeing the difference between the two experiences.

27-year-old male. 10 years of hand pain is gone. Chronic back pain and pelvic floor damage are gone, and bloating is fully gone. My cycle is 3ml BAC water with Wolverine stack. 21 days running recovery is amazing.

Hello, so growing up I had gyno from puberty and it was never anything super bad but really affected me mentally. After 3 years I think I’m finally starting to feel better about myself and my gyno regression. To all my gyno bros out there feeling discouraged, don’t give up there is hope!