r/Biohacking

I started enclomiphene recently as my T is 194. I essentially have secondary hypogonadism that is obesity related. I am also taking DHEA. Anyone have experience with this and can attest to whether or not it raised T levels and by how much?

I recently got hgh from strate labs after doing research. I went ahead and came to the conclusion it's legit so I went ahead and ordered some. Before the hgh I got my igf1 tested and it came back at 260. A few weeks after 3ius I got my igf1 tested again and it came back at 145.

Im not sure if this is caused by the 1000 calorie deficit i've been doing as well but I highly doubt it.

I just got my reta shipment in and i forgot to take the bac water out before putting it in the fridge. it’s been in there unopened for 2 days, should i just take it out and use it or buy a new one. ik it can make ur peptides cloudy which i dont really feel like dealing with

What helps with anhedonia? Literally my lab rat has been so unmotivated since starting Reta. Things they used to love just don’t hit the same.. thanks in advance!

I don't know what to do anymore...but I think I have to give up :( I've been taking GHKCU for 4 weeks and it's painful. I've tried lots of things: adding backwater, room temperature, very slowly, injecting into the glutes, injecting at 2 different sites....have I really tried everything?

Looking for best Memorial Day weekend sales or promo codes on the clear net?

I know you can get it so much cheaper on the gray if I find the right vendor but I don't have time to vet 14 telegram shit heads and balance a flaming bowling pen just to get some shady WhatsApp vendor to send me some powder. Forgive me in advance

How do I know if my Reta is actually reta?

Because I bought it from an American supplier and in 2 months I lost 2 kilos and 3 centimeters from my waist. I already have an athletic body, but I thought the effect would be greater. My hunger has decreased, but when I eat fattier things like cheese, I get heartburn.

I started the protocol with 0.5 and today I take 2.5.

Any suggestions?

Whats everyone's expirence with pt141 while being on antidepresants or antipsychotics

I was having some stomach issues on Reta, not terrible but definitely noticeable and wanted to find a way to get rid of it. I was already planning on adding GHK-cu, so figured why not just spring for GLOW and see if the BPC-157 will help my stomach. Since getting on my issues have totally resided, even as I upped my dose of Reta no more issues!

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For most of my life I believed the standard narrative:

eat less

move more

fat is bad

calories are what matter most

But my lived experience never matched that model.

I’m a large-framed guy with a long history of obesity, blood pressure problems, inflammation, unstable energy, sleep issues, and what felt like a body constantly fighting itself. I also grew up during the peak low-fat/high-carb era, and for years my diet was driven more by survival and affordability than biology.

Recently I started aggressively tracking:

weight

glucose

ketones

blood pressure

pulse

waist size

food intake

fasting response

What surprised me most is that my system appears to respond far more to fuel type than simple calorie math.

When I reduce carbohydrates heavily and increase fat intake substantially, several things consistently happen:

hunger drops dramatically

fasting becomes sustainable instead of miserable

inflammation appears to decrease

glucose stabilizes

ketones rise reliably

weight loss accelerates

mental clarity improves

energy becomes steadier

I’ve now lost over 90 pounds from my peak, and the strangest part is that some of my best metabolic stability has occurred during periods where dietary fat intake was extremely high.

That has forced me into a weird place psychologically because it contradicts decades of assumptions I had about nutrition.

I’m not posting this as universal advice. I’m also not claiming calories are imaginary. What I am saying is that for my body, calories from different fuel sources do not appear to produce equivalent biological outcomes.

Another thing I’ve been wrestling with:

sometimes the scale changes faster than the mind does.

I hit numbers I thought would feel life-changing, and emotionally I often feel… almost nothing. It’s like my brain still expects survival mode even while my body is changing.

I suspect a lot of that is tied to lifelong obesity, stress conditioning, and trauma patterns around survival and self-worth.

At this point I’m less interested in ideology and more interested in understanding mechanism.

So I’m curious:

Has anyone else experienced dramatically different outcomes based on fuel composition rather than just calories?

Has anyone else found very high fat intake unexpectedly stabilizing?

Did massive weight loss change your psychology slower than your body?

I’m genuinely interested in thoughtful discussion and other people’s lived experiences.

Hi everyone,

I’m new to this group and I’m looking for advice on where to start.

I’m a 22-year-old male, 173 cm / about 5’8”, around 70 kg / 154 lbs. My main issue is stubborn belly fat. Even in 2024, when I was around 61 kg / 134 lbs and training almost every day with weights, I still had annoying lower belly fat that never really went away.

I recently started training again after a difficult breakup. Right now I swim 3 times per week, about 1 hour and 15 minutes per session. I currently take basic supplements like protein, creatine, vitamins, etc.

My biggest problem is sleep. I usually sleep 7–8 hours, but I go to bed around 3–4 AM, and this affects my daily life a lot. I’ve had sleep issues for around 7 years, and despite doctors’ advice, I’ve never fully solved them.

I’ve also been reading about peptides and compounds such as Selank, Semax, Ipamorelin, GHK-Cu, NAD+, and similar options. I’m not looking for dosages or medical advice, but I’d like to understand whether any of these are actually worth considering, or if it would be smarter to focus first on sleep, training, diet, bloodwork, and routine.

If you were in my situation, what would you prioritize first?

Thanks in advance for your patience and advice.

Been using NAD+ injections for about a week now and honestly I feel like complete garbage.

Extreme fatigue, muscle aches, brain fog, and I’ve been sleeping like a Russian submarine. Zero energy at all.

Yesterday I did a 50mg injection.

My vial is 1000mg mixed with 4mL bac water.

Just wondering if this is normal when starting NAD+ or if my body is reacting badly to it. Did anyone else feel worse before feeling better?

Trying to figure out if I should push through it or stop completely.

I have been suffering with brain fog, low energy and fatigue for a while now. Can barely sleep more than 7.5 hours usually get 6.5-7.5 hours of sleep each night.

Currently losing weight down about 16lbs in last month but I never felt this bad even when I weighed 50lbs more.

Took last tirz 2.5mg shot 2 weeks ago, starting Reta in 2 weeks and currently interested in some other peptides but not sold yet.

Anyone suffered similar experience to me? Not looking for specifically peptides to cure my issues open to other suggestions to.