Image 1 — 12 months on retatrutide - down 35kg
Image 2 — 12 months on retatrutide - down 35kg
Image 3 — 12 months on retatrutide - down 35kg
▲ 405 r/PeptideLogbook+2 crossposts

12 months on retatrutide - down 35kg

Anxious for no real reason but here we are.

48 years old, started at the end of July 2025, second pic is exactly 12 months and 14 days later. Down 35kg total and actually put on a bit of muscle in the process which I honestly didn't expect.

Dosing:

  • July-Nov: started at 2mg, went up pretty slow, didn't hit 4mg until around week 16
  • Dec onwards: sat at 4mg for a while, bumped to 6mg around February and that's where I've stayed
  • Titrated slow on purpose bc I read too many horror stories about nausea and wanted to actually stick with it long term

Training:

Nothing fancy, just consistent. 4 days a week lifting (upper/lower split), started adding in incline walks around month 3 once the energy came back. Added actual running in December, could not even do 1km without stopping in November, ran my first proper continuous 5k in March in just under 30 min. Ridiculously proud of that tbh, more than the number on the scale honestly.

Food:

Started around 1600-1700kcal which was rough the first few weeks (side effects + deficit combo is not fun). Once appetite suppression kicked in properly it got way easier to sit there without white-knuckling it. Slowly brought it up to around 2000-2200 as activity increased.

Side effects:

Fatigue was the worst part for me, especially first 2 months. Some constipation early on, nothing crazy. Got bloodtests done at start and around month 9 nothing concerning, doc was happy with them.

Where I'm at now: dropped down to a lower maintenance dose just to hold where I'm at while I focus on building the running up and not losing more muscle. Eating closer to maintenance now too.

Thanks for reading, ask away if you've got questions, happy to answer whatever.

u/LittleSea7603 — 2 days ago
▲ 3 r/NextGenBiotech+1 crossposts

Top 10 Most Popular Peptides August 2026

In my time in the peptide space reading forums, and Reddit threads trying to understand peptides. I noticed the same compounds kept coming up over and over, so I figured I'd make a simple list for anyone who's just getting into this space.

Here's a summary of what each peptide is most commonly researched for and how much human research currently exists.

Rank Peptide Common Research Interests Level of Human Research
#1 Tirzepatide • Weight loss • Appetite suppression • Blood sugar control • Metabolic health ⭐⭐⭐⭐⭐
#2 Semaglutide • Weight loss • Appetite control • Type 2 diabetes • Cardiometabolic health ⭐⭐⭐⭐⭐
#3 Retatrutide • Weight loss • Fat reduction • Metabolic health • Triple hormone agonist (GLP-1/GIP/Glucagon) ⭐⭐⭐☆☆
#4 BPC-157 • Tendon repair • Ligament healing • Muscle recovery• Gut health • Injury recovery ⭐⭐☆☆☆
#5 GHK-Cu • Skin rejuvenation • Collagen production • Wrinkle reduction • Hair growth • Wound healing ⭐⭐⭐⭐☆
#6 CJC-1295 + Ipamorelin • Growth hormone release • Recovery • Lean muscle support • Sleep quality • Body composition ⭐⭐⭐☆☆
#7 Tesamorelin • Visceral fat reduction • Body composition• Growth hormone stimulation • Metabolic health ⭐⭐⭐⭐⭐
#8 TB-500 • Soft tissue repair • Muscle recovery • Wound healing • Inflammation support ⭐⭐☆☆☆
#9 MOTS-c • Mitochondrial function • Exercise performance• Insulin sensitivity • Healthy aging ⭐⭐☆☆☆
#10 Semax / Selank • Focus & concentration • Memory • Mental clarity• Anxiety reduction (Selank) • Cognitive performance ⭐⭐☆☆☆

Star Guide

⭐☆☆☆☆ = Very limited human evidence (mostly animal/lab research)

⭐⭐☆☆☆ = Early human studies

⭐⭐⭐☆☆ = Moderate human research

⭐⭐⭐⭐☆ = Good amount of human research

⭐⭐⭐⭐⭐ = Extensive human research and/or FDA-approved for at least one medical indication

One thing that stood out to me while putting this together is how much the peptide landscape has changed over the last few years. A while back, it felt like BPC-157 and TB-500 were highly experimental but now there are many stories of athletes healing torn ACL's or recovering from surgery much quicker.

I'm sure everyone would rank these a little differently, but based on what I've seen across Reddit, research forums, and peptide sites, this seems to be a pretty fair representation of what's most popular today.

reddit.com
u/LittleSea7603 — 16 days ago