u/BackgroundSalad1571

Hi fellow 40+!
Some positive news for those of us with low blast conversion. Last year at 41 I did 4 rounds locally and out of 31 or so eggs ended up with 4 just blasts. 1 segmental aneuploid and 3 aneuploid (two rounds were 0 blasts). I was exercising, eating well, supplements etc but in two of the 4 rounds we got 0 blasts. After feeling so discouraged in December and a barrage of medical things (one being we went to prep transfer for our segmental and I was mistakingly told a polyp was atypical hyperplasia and a hysterectomy was on the table) we did a round a week ago at Cornell.

We took a very expensive risk and spent 10 days in the city, cash pay IVF, etc.. out of our 7 eggs retrieved, 4 mature (1 additional was matured with IVM but didn’t fertilize), 3 fertilized and we got 2 blasts today! We decided not to test this round bc at this point I want to at least attempt transfers. I know this outcome isn’t perfect but after two rounds with zero blasts and anxiety like crazy, I am thrilled for now.

My results were drastically better than the 4 rounds prior AND I am now 42.5. AMH also fell from 1.28 to .26 and had me stressing.
Maybe it’s the lab, maybe it is the host of other things we changed but I’ll take it!

Ps. Don’t take all the blame. Turns out my husband had grade 2 vericocele which we corrected and I was put on Metformin. Always be advocating!

Hi there. I’m gearing up for a 4th egg retrieval after 7 months off for various medical reasons. I ovulated Monday and had baseline scan today (first time since December) for luteal stim start.

42 years old. Never pregnant. No health issues.

I have 10 follicles as of this morning.
My AMH dropped to .26 when I randomly had it checked in June for the first time in a year (was 1.68 year prior).

I was pretty shocked and worried so I’m curious what you guys think about 10 follicles at baseline?

This retrieval will be at Cornell and I’m based in Louisiana. Putting alot of eggs (no pun intended) and $$$ into this last shot so want to be very strategic. As always thanks for your input!

Good morning fellow 40+ IVF friends,
At 42 after 4 mediocre rounds at my private equity owned clinic, I am throwing in the kitchen sink and traveling to NYC at the end of the month for a round at Cornell with Dr. Irani.

This is our second out of pocket round and will likely be the deciding factor in egg donor or not afterwards.

I am reaching out for any Hail Mary information from you guys. Things you cut out (skincare, coffee, hot baths, intense exercise, etc..), added (supplements, Omnitrope, IVM, anything!).

Dr. Irani doesn’t seem to be a fan of Omnitrope. I used it for all rounds here and ended up with 4 aneuploids and a segmental aneuploid out of over 30 mature eggs. Bummer.

I’ll be microdosing lupron for the first time and doing my third luteal start (I historically produce more eggs in this window).

Alllll the supplements for months and months as well as Metformin and Inositol. No alcohol for two years and consistent exercise. Weekly acupuncture for the last 8 weeks.

Thanks in advance for all your advice and thoughts!

Hello IVF Friends,
Who here still enjoys their daily coffee(s) before/during stims?

I have been swapping my morning brew at home with 1 scoop decaf 1 scoop regular and then a second cup at work same thing or full decaf.

I enjoy taking a break from work in the afternoon with a drink but trying to sub tea. Wondering who gave up entirely and do we think it matters as long as we stay around the recommend 200mg a day? I quit drinking alcohol almost two years ago so I need to enjoy something on this journey! :)

But of course would cut out completely if we thought it would make a difference..

Hi! I am switching clinics and will be doing a few days of remote monitoring in New Orleans before traveling to NYC for additional monitoring and retrieval. Anyone else happen to do this same thing with Cornell? Curious about any favorite hotels or apartments for an extended stay/fridge for meds/room to relax. Thanks so much 😄

Hi all. After a failed round with our local clinic we are transferring to Dr. Irani at Cornell. AMH was a required test and I was a bit surprised and upset today to see how much my number has dropped in a year. I know that’s just part of the process, and had some concerns, especially at 42.

My last retrieval in December yielded 9 eggs but we haven’t done one since due to non IVF related medical issues.

We will do a retrieval in July and our new doctor recommends micro-dosing Lupron. I am looking for anyone with a similar AMH that has still had any luck with IVF and also anyone who has tried the microdose Lupron protocol?

Luteal start - It sounds like I’ll do just Lupron for 1-2 nights then introduce 300 gonal and 150 menopur (the two retrievals I had that failed previously included 225 menopur).

Thank you for your help and feedback! Best wishes to everyone on this journey.

***editing post bc just read inositol can cause AMH to falsely lower if you don’t have pcos. I do not and have been taking it as well as metformin for 5 months.*** has anyone else heard this before?

Hi all. Long post incoming. I am hoping this community can provide some insight and recommendations. I am based in New Orleans with only two clinic options.

Last year at 41 (husband also 41) I had 4 rounds of IVF. AMH 1.6. Never been pregnant. Never tried naturally- straight to IVF for age purposes. BMI of 20.5

May -Follicular phase Round 1: 5 eggs retrieved/4 mature/3 fertilized - 1 aneuploid (menopur 150)

July -Follicular phase Round 2: 5 eggs retrieved/4 mature - 0 blasts made it today 5 (menopur 225)

September- Luteal phase Round 3: 12 eggs retrieved/9 mature/6 fertilized - 1 segmental aneuploid, 1 chaotic, 1 aneuploid (menopur 150)

December-Luteal phase Round 4: 9 eggs retrieved/6 mature/ - 0 blasts made it to day 5 (menopur 225)

All rounds used Omnitrope during stims only, approx 300 Gonal throughout, dual trigger for all. ICSI and Zymot for all. Acupuncture during two of the rounds.

Taking ubiquinol, fish oil, vitamin d,k,c, prenatal multi, acai, alpha lipoic acid, tru niagen, metformin, inositol, magnesium, 3 mg melatonin, daily zyrtec and flonase (not for fertility purposes).

Husband and I have been alcohol and drug free for 18 months, consistent exercise and daily steps as well as mostly healthy diet. I am trying to cut down coffee - currently at 3 cups per day or so.

• Since the failed cycle in December, we have switched doctors. I am now on Metformin and Inositol. Husband had surgery for grade 2 varicocele (DNA frag was 23% pre surgery and good semen analysis pre surgery).
• I also requested a host of bloodwork and found out I am low in iron, iron storage/circulation and B12. Beginning to supplement these as well.
• We have also had a consult with Dr. Irani at Weill Cornell.
• A saline sonogram found polyps when we were prepping to transfer our segmental aneuploid in April. I have since had a D&C to remove hyperplasia with atypia.

We are now at a crossroads to do one of the following:

Transfer segmental aneuploid - our clinic here and Cornell encourages whenever ready

Another retrieval locally -not super confident in lab capabilities here

Retrieval in July with Weill Cornell - NYC

I am looking for any advice on protocol, add on's, clinics with success over 40 or anyone who personally used Cornell and feedback on it. Our December round was out of pocket and this next one will be so I am trying to be strategic while knowing I did everything we could before pursuing donor eggs. Such an emotional and expensive journey! Thanks so much.