u/Certain_Cookie_5917

I have a strange form of depression that involves chronic, contentless, existential dread. I knew ketamine was a bit of a long shot being that there’s no data on my condition but I didn’t know what else to try so I gave it a go. Over the first 3 infusions I felt like I was actually making some slow and steady progress. The 3rd infusion felt amazing and was filled with incredible insights. I felt like I was giving myself the cheat codes for how to get out of this. I was so excited because it felt like after years of being stuck I was finally making progress.

But then 2 days ago I had my 4th infusion and instead of insights all this one did was increase the dread for 40 minutes. The dread has remained elevated a couple days after the infusion and I feel terrible again. I’m worried that this infusion undid my progress from the first 3 and I’m confused why this happened. Has anyone had anything similar happen to them? Anyone had an infusion make them feel worse and still have a good outcome overall? Any advice is much appreciated!

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I have severe depression with chronic psychological pain. I took one 25 mg pill of fluvoxamine 3 months ago and it immediately made my psych ache significantly worse and it has stayed worse. Has anyone else had the experience of an SSRI making them worse permanently? Anyone have any ideas of drugs that could do the opposite of what fluvoxamine did?

So I had a really stressful year in college filled with emotional abuse, academic overload, multiple viruses and burnout. When I finally returned home to rest I completely crashed. One night, a few nights after I got home, I was sitting around when randomly I started to feel this intense sensation of dread/dysphoria wash over me. It was like this deep pit of horribleness in my stomach, this feeling that something is horribly wrong. It was so intense my whole body was trembling. It felt like it would never end. And it didn’t. At the beginning it was more episodic but after a few weeks it kinda just faded into the background of my existence. For the last 2 years I have been living with this feeling all day every day. It doesn’t fluctuate much, it’s completely environmentally unresponsive, and it seems completely devoid of any content or meaning. It makes every moment feels unbearable and I genuinely am not sure how much longer I can handle it.

The symptom is accompanied by anhedonia, fatigue and upper body tension, all chronic and just as unresponsive to circumstances. To be clear, the feeling is distinct from anxiety because it does not involve worrying thoughts, racing heart or hyper vigilance. It’s more like unrelenting psychological pain. At this point in order to save my life I need to start trying treatments but I have no idea where to start. Has anyone ever seen a symptom like this before? Any suggestions of what treatments might actually help it? Any advice at all would be so apreciated.

So I had a really stressful year in college filled with emotional abuse, academic overload, multiple viruses and burnout. When I finally returned home to rest I completely crashed. One night, a few nights after I got home, I was sitting around when randomly I started to feel this intense sensation of dread/dysphoria wash over me. It was like this deep pit of horribleness in my stomach, this feeling that something is horribly wrong. It was so intense my whole body was trembling. It felt like it would never end. And it didn’t. At the beginning it was more episodic but after a few weeks it kinda just faded into the background of my existence. For the last 2 years I have been living with this feeling all day every day. It doesn’t fluctuate much, it’s completely environmentally unresponsive, and it seems completely devoid of any content or meaning. It makes every moment feels unbearable and I genuinely am not sure how much longer I can handle it.

The symptom is accompanied by anhedonia, fatigue and upper body tension, all chronic and just as unresponsive to circumstances. To be clear, the feeling is distinct from anxiety because it does not involve worrying thoughts, racing heart or hyper vigilance. It’s more like unrelenting psychological pain. At this point in order to save my life I need to start trying treatments but I have no idea where to start. Has anyone ever seen a symptom like this before? Any suggestions of what treatments might actually help it? Any advice at all would be so apreciated.

So I had a really stressful year in college filled with emotional abuse, academic overload, multiple viruses and burnout. When I finally returned home to rest I completely crashed. One night, a few nights after I got home, I was sitting around when randomly I started to feel this intense sensation of dread/dysphoria wash over me. It was like this deep pit of horribleness in my stomach, this feeling that something is horribly wrong. It was so intense my whole body was trembling. It felt like it would never end. And it didn’t. At the beginning it was more episodic but after a few weeks it kinda just faded into the background of my existence. For the last 2 years I have been living with this feeling all day every day. It doesn’t fluctuate much, it’s completely environmentally unresponsive, and it seems completely devoid of any content or meaning. It makes every moment feels unbearable and I genuinely am not sure how much longer I can handle it.

The symptom is accompanied by anhedonia, fatigue and upper body tension, all chronic and just as unresponsive to circumstances. To be clear, the feeling is distinct from anxiety because it does not involve worrying thoughts, racing heart or hyper vigilance. It’s more like unrelenting psychological pain. At this point in order to save my life I need to start trying treatments but I have no idea where to start. Has anyone ever seen a symptom like this before? Any suggestions of what treatments might actually help it? Any advice at all would be so apreciated.

Over Daniel!!!!?????