u/ChollyWheels

I started tirzepatide OVER 3 years ago, and lost weight on it very rapidly (290 down to 190 at my low -- about 15 lbs over my ideal weight, and the lowest I've weighed in 40 years). I titrated up to the max dose pretty quickly. But after about 1.5 years weight started creeping back up... slowly. Now I'm up to nearly 230. Yikes! Not horrible, but the trend is in the wrong direction.

This is a disappointment, but not a shock. It's story with many drugs, and in particular weight loss drugs -- after awhile, they work less well in some cases (some people seem to do fine on a low or intermittent dose).

So, what to do?

-- stop, and hope it's more effective if I return after a break. This risks major weight gain.

-- adjunctive therapy -- ADD something. Possibilities: Phentermine, Topamax, Cagrilinitude...

-- switch to something else.

Has anyone tried switching to Retatrutide when Zepbound becomes less effective? Did you wait a week or more after the last Zepbound dose, then start Retatrutide at the lowest starting dose for that drug? I do not know of any investigations along such lines, since Retatrutide is not yet on the market (and may never be approved for it)

SDST is a fallen angel of the  battery-grade lithium products class - lots of competition, decreased government support, and it crashed from a brief high of 159 to a recent price of under 3. It may be in danger of being delisted because the market cap is $27m (below the $35m, which is the requirement I think).

As of early 2026, the company has completed key engineering and permitting milestones for its planned 50,000 metric ton per annum (MTPY) capacity refinery -- nice story, but among many similar stories of big plans and ground breaking and no operations and the likelihood of more dilution ahead.

To me, the wild card is what the next months will bring -- if gasoline prices spike as madly as some predict. In that event, EVs may start looking much more appealing -- in an economy where fewer people are going to be able to afford rice & beans, let alone a new car. Another wild card is whether AI will crash, taking down electricity prices as the amazing achievements of AI are revealed not to justify the more amazing money spent on it.

So I lack conviction - having no idea how likely the people behind SDST have what it takes really to build a business, and soon. Might be worth a toss of the dice with a few bucks.

Thoughts?