u/Dry-Dragonfruit5216

Hi, I can’t find much about this online from medical sources so I was wondering if anyone here has any experience of this.

I’ve had chronic depression since puberty and it runs in my family. I was so used to my mood being low or at best just flat that I thought this was normal, that people on TV exaggerated what being happy looked like. I couldn’t think of a memory where I was genuinely happy. I tried multiple antidepressants and anti anxiety meds but nothing helped. My doctor said that I was a person who didn’t respond to antidepressants which is unhelpful. I was always having suicidal thoughts, often engaging in self harm or fighting against strong self harm urges, and there were times I did actively try to end my life.

The NHS refused me individual therapy so I tried group therapy (CBT I believe) but in the first session when we were talking about things that triggered our anxiety or depression and it didn’t go well. Everyone else gave an example and we came up with ways to mitigate the emotional impact but my example the staff told me that they couldn’t help and I’d just have to live with it. It’s a big struggle that is caused by my level 2 autism but they’re not equipped to help with that and the NHS in my area doesn’t seem to have anyone who can help.

I thought this was going to be my life and I’d die young through not caring about my health or risks. If I got hit by a car tomorrow I wouldn’t care. When my cholesterol came back a bit high at 20 years old I didn’t care. If I one day got an infection where I harmed myself I wouldn’t care.

Then I started on Mounjaro and everything changed. It was gradual so I didn’t notice for a few months but within a few weeks I stopped taking my antidepressants. I didn’t feel the need for them so kept forgetting, I didn’t even feel worse stopping them cold turkey when they’re the kind that you have to gradually reduce. I started feeling happy doing things and found things I enjoy. I started being open to socialising at a disabled adult group I attend and this led to me starting to build some confidence. I’ve been learning to say no to people and practicing standing my ground. Whilst I have a long way to go with all of this it’s been such an improvement.

However my BMI has dropped below 20 (fluctuates around 19.0-19.5) so I can’t delay titrating off any longer. So far I’ve been extending my dose window to 12 day and was supposed to go from 7.5 to 5 this week. But after around 9 days I felt the meds wear off and everything was quickly returning to before MJ. I knew things weren’t great but it was 12 hours after I injected 7.5 that I realised I felt really good again and how much impact the med has on my mood. It also helps with things like motivation, sleep/energy, bloating, and hunting sugar constantly.

I have already ordered the 5mg pen and will titrate down to it because I have been slowly losing on 7.5 when I was supposed to be maintaining. But now I’m wondering if I’m someone who needs to be on it for life. But then is mental health improvement even a legitimate reason to stay on a low dose of MJ? I don’t think it’s a placebo effect either. I can’t find much research about mood improvements on MJ other than feeling more body confident but that was not my issue.

Do I try to titrate off even slower? Do I try to convince my parent (I live at home) that I’ll need to keep paying for this? I’d like to be stable at least on 5mg because it’s so much cheaper than 7.5mg, though realistically even 2.5mg monthly is very expensive.

Mounjaro seems to be the most effective antidepressant (and anti-anxiety med) I’ve ever tried and now at my goal weight I’m not sure what to do.

Hi. I lost 102 lbs on MJ and spent most of the journey on 5 mg with 7.5 mg to lose the last bit and maintain. I planned to lose 7 lbs under my goal so I had a buffer but I ended up very slowly losing another 15 lbs instead. Because of this I have decided that now I will be lowering my dose back to 5 mg. Previously I had managed to spread my 7.5 mg to every 12 days.

I’ve been reading posts on this sub and making notes of what worked for people. You all have some amazing advice and very inspirational stories, thank you so much for sharing them! Today has been a very difficult day for me with my cat currently having surgery (I’m level 2 autistic and he’s a big part of my support), family drama, and my period being overdue so I still have the munchies. Because of this I’ve eaten like crap today and for a few hours I gave up. A post from this sub came up on my feed and after reading this sub for a couple of hours I feel a bit better and motivated to not eat myself back to obesity.

The wobble today has made me more self aware of how easily I can still give into cravings and shrug aside accountability. I need to be more prepared for lowering my dose this weekend. Having lost so much weight I’ve ended up buying a whole new wardrobe (mostly second hand) and can’t let that money plus the MJ money go to waste.

I would love to learn more about the science behind weight struggles and how to maintain after losing weight and GLP-1s, both the physical biology and the psychological sides of it. Also I’d love to read about ways to successfully maintain. If anyone here has any resources that helped them or found interesting and could share them I would be so incredibly grateful. Or even sharing things that worked/didn’t work for you personally. Free things are great but I also don’t mind things behind a paywall, it’s an investment in my health after all. It’s worth noting I’m also a very short woman from a family where everyone is very obese and I have level 2 autism and ADHD (childhood diagnosed and been on stable meds for many years) which contributes to the psychological side of weight issues. I have a degree in a field of human biology so I don’t have any problems with reading technical things either, so if there are any other biology nerds here I’m open to an infodump :)

Thank you everyone for creating this amazing community that has already helped me so much today. I plan to be a lot more active here as I titrate down MJ and keep myself accountable. Maybe one day I’ll even be able to post my own success story and help other people.