What are your thoughts on this perspective? As a newer user, my dose is relatively low, but anhedonia is a concern for me. I do feel a little bit dull emotionally, But the benefits of losing weight and feeling better about myself seem to outweigh this. IDK.
I just wanted to say, first and foremost, that I apologize for any information that may sound like I am misled on because I don’t quite understand this stuff as much as my mom does, but I’m just trying to help her out by reaching out to this subreddit. She’s always busy and I have tons of time so I will help out.
My mom is 60, and has been on Wegovy since around August 2025. Every shot she has taken, which has been weekly, she has felt absolutely horrible with no sign of getting used to it, and her doses keep increasing before she has any chance to do so. Her symptoms are mostly nausea and her mood down.
She used to go to the gym all the time, and became really fit around 2014-2017 and her energy and mood were at its best, but I guess as she has gotten older, hormones have taken over and have made it really hard for her to maintain her weight loss. I’d say she started to experiment with weight loss medications around 2020-2021. I believe it was Red Mountain weight loss and that did wonders for her. She didn’t get sick off of them and saw results, but they became super expensive and outpriced her so he had to stop.
We used to go to the gym in the mornings around 3-4 years back, and we carried that on for a few months, but she didn’t really feel it. She never sweated and she just didn’t feel like she was getting much out of it even though she wanted it to so we just gradually stopped going. She did go for morning walks every morning around the same time but that started to cease somewhat before she got on Wegovy and when she got on Wegovy, she didn’t want to go at all.
There’s a lot of stuff with her diet that I’m not totally well versed on so I will refrain from speaking on it, but I know she has had to adjust based on her Wegovy intake. On the days she gets the shots, she’ll eat a small dinner or won’t eat dinner at all. And on the days after the shots when she’s feeling the worst, she’ll eat smaller meals like crackers and such. She really only feels the worst on the day after the shot, and a little bit into the day after that, and then she feels better until she has to do it all again.
It’s gotten to the point where she really wants to ween off of it. She has only been able to get 23 pounds shed from the medication and she said she should really be close to 40 by now, a year after starting. It really feels like the negatives are outweighing the one semi-positive result at this point.
She also has a problem with heartburn and indigestion, and she really thinks her gut microbiome is out of sorts, which I guess is commonplace everywhere but I thought I would mention it.
We have explored doctors and such, and she has insurance but a lot of the places we feel are best in terms of functional medicine do not take insurance, instead opting for direct cash pay which can be very expensive. We live around the Houston area and she has been with Kelsey-Seybold Clinic with doctors there, but they don’t seem to be as hands on with this kind of stuff as we would think. She really doesn’t like doing all of the weekly telemedicine visits and checkups haha.
Her biggest fear, of course, is regaining all of the weight back, unable to do anything about it, along with all of the other potential risk factors getting off GLP-1s even if she starts committing to exercise again, along with calorie counting and diet watching.
I know this was long, but I’m coming to the people of Reddit hoping there may be anything we can do for her to get off Wegovy without misery, if that’s even feasible, which hopefully it is.
🎉Goal reached🎉
Starting weight: 292 lbs
Goal weight: 150 lbs
Current weight: 149.4 lbs
142 pounds gone
This journey has been about so much more than the number on the scale. I’ve gained strength, confidence, healthier habits, and a version of myself I honestly wasn’t sure I’d ever meet.
It wasn’t quick or easy. There were plateaus, setbacks, days I wanted to quit, and plenty of lessons along the way. What got me here was staying consistent more often than I was perfect. A supportive family, tracking my calories and macros, strength training, using a GLP-1 as a tool, and choosing not to give up even when progress felt nonexistent.
To everyone who’s followed along, encouraged me, or cheered me on, thank you. Your support has meant more than you will ever know!
This may be my last weight loss update, but it’s not the end of my journey. Now the focus shifts to maintaining, getting stronger, and continuing to build a healthy life that I love.
If you’re just starting your own journey, keep going. One day you’ll look back and realize those small, daily choices added up to something incredible and your future self will be so grateful.
I would be lying if I said I wasn’t a little nervous, but here’s to the next chapter. 🩷
Does anyone have any experience with TTC and quitting a glp?
I’ve been on 5mg Tirz for about 2 years and doctor said it’s time to quit so we can go ahead with fertility treatment.
And I'm back again with another post-GLP update!
It's been 10 months since I took my last Zepbound shot, and in keeping with my promise to keep y'all updated on my maintenance journey, here we are.
As usual, here's the Cliff Notes version of my GLP-1 journey: I'm a 35-year-old, 5'3" woman who was on Zep for 13 months, with 5mg being my highest dose. I started at 185 lbs (class 1 obese), and reached my lowest weight at 117 lbs before stopping treatment in October 2025.
Since then, I've been focused on building muscle and body recomposition. Below are my quarterly DEXA results.
| Metric | Oct 2025 | Jan 2026 | Apr 2026 | Total |
|---|---|---|---|---|
| Weight (lbs) | 117 | 121 | 124 | +7 |
| Body fat % | 26.9% | 25.4% | 24.1% | -2.8% |
| Fat mass (lbs) | 32.4 | 32.4 | 31.3 | -1.1 |
| Lean mass (lbs) | 87.9 | 95.4 | 98.7 | +10.8 |
As you can see, I may have gained 7 lbs since stopping Zepbound, but that gain has been entirely attributable to body recomposition.
One important note: I've stopped getting quarterly DEXAs for now. Both my OBGYN and cardiologist strongly recommended that I pause further body fat loss while my partner and I are trying to conceive (since improving my health and fertility was the primary reason I started GLP-1s in the first place). I'll resume DEXA scans postpartum.
Because of that shift in priorities, I've been in maintenance mode and have averaged around 125 lbs over the past several months (I weigh daily and track weight trends rather than focusing on day-to-day fluctuations). Strength training remains completely non-negotiable, and my nutrition continues to center around mostly whole foods.
I've also fallen in love with endurance cycling, which has become a huge part of my life. Since my last update, I've completed three races and have one more on the calendar before the season wraps up.
One major change I wanted to highlight is that I've started working with a sports nutritionist. Since June, we've increased my intake by an average of about 500 calories per day. I'll admit, that made me a little nervous at first, but I trusted the process. Not only am I maintaining my weight, but my body is functioning so much better. My recovery has improved, I have significantly more mental energy, and my stress and anxiety levels are at an all-time low, even during what's been a pretty fast-paced season of life.
It's so important not only to eat enough to support your activity level, but also to eat enough to recover from it. That means getting the right balance of macros and prioritizing high-quality, nutrient-dense foods.
Anyway, I feel like I've already written extensively about my journey in previous posts and comments, so I encourage anyone interested to browse my post history. Or feel free to AMA below, and I'll answer as best I can.
EDIT: for some reason, I accidentally deleted a huge part of my post before hitting the button, but I do want to say that I still firmly believe that weight regain is not inevitable after stopping a GLP-1. That doesn't mean maintaining weight loss is effortless, and it certainly doesn't mean everyone should come off their medication. For many people, long-term treatment may be exactly the right choice. But I do think the conversation around GLP-1s can sometimes become overly deterministic. Our outcomes aren't defined solely by whether we're taking a medication or not. The habits, nutrition, movement, and lifestyle changes we build along the way matter too. My experience is just one data point, but 10 months later I'm maintaining my weight, fueling my body better than ever, and continuing to get stronger. I hope that provides some encouragement to those who worry that regain is a foregone conclusion.
If you can.. get active y’all.
I promise, I understand the excuses we give ourselves.
I’m too tired. I don’t feel good. Bad day. No time.
Take your pick of excuse. I’ve been there. I used to have horrible knee, shoulder, and feet pain. Purely from being too heavy for my frame. It prevented me from doing anything. But you have to simply start.
Pain. Pain is the thing we try to never experience in life and our bodies. We don’t want pains of hunger. Pains of body.
Pain is temporary. Pain lessens as you build your strength.
GLP1s are amazing. But they are not liquid accountability.
They also will cause you to lose muscle mass from reduced caloric intake. So it’s really important to do heavy lifts and resistance training. GIVE YOUR MUSCLES A REASON TO EXIST.
There is always something you can do! You don’t need a gym. You don’t need to do anything other than SOMETHING.
It’s small consistent steps with big results. You got this. You reading… YOU got this.
For those of you who ended up quitting “cold turkey,” what MG were you taking before you stopped?
I have 2 last 5mg injections of TIRZ and then I’m out of meds. 🫤
Hi there. I posted about a year ago about using Zepbound only when needed to maintain a goal weight. A sort of “graduation” I guess. This is an update on how that is working for me. I started with a 2.5 mg dose 12/30/24. Starting weight was 215.5 lbs. Switched to 5 mg 43 days in, continued until 5/12/25, when I reached my initial target of 175 lbs. I stopped the medication at that point.
I gradually gained weight and took a single 2.5 mg shot 103 days after stopping. I lost to below 175 and stayed there for 87 days.
I gradually gained weight and took a single 2.5 mg shot, lost to below 175 and stayed there for 92 days.
I gained weight more rapidly this time and stayed at goal for only 25 days. I revised my goal to “below 170 lbs.” and a 2.5 mg shot and then two 5 mg shots were taken over a 3-week period.
I have repeated this cycle now a total of 8 times. These included durations of 46 days, 35 days, 71 days, and 48 days. I exceeded my target 8 days ago and took another shot then. The average duration between shots over these 8 cycles, including the current one, is now 52 days. Other than as mentioned above, a single 5 mg shot has been taken each time. My current weight is 164 lbs.
The efficacy of the drug, side effects, etc. have not varied for me at all over this period. I discussed this approach with my PCP at my annual checkup, and he is fine with it, but does not want me losing any more weight.
I work out daily, eat well, drink some wine (less than before), and don’t count calories. I have basically eliminated most carbs from my diet. Bread, potatoes, rice, etc. are out and fruits and vegetables are in. Protein, sauces, low cal sweets a regular part of diet daily.
I’d be really interested to know about others experience with this approach. Does it work for you? Any problems or issues?
Thanks and good luck to all!
I've been on Zep for 6 months. I'm currently on 15mg dosage. Insurance has dropped me and I can only afford a couple of months out of pocket. I've seen a lot of advice about tapering including extending time between doses to 10 to 14 days. I'm wondering if someone has a suggestion for a reasonable fixed schedule I could follow. Tomorrow will be day 10 for my 15mg dose. I plan to do a full 15mg them. I have another Kwikpen arriving (four 15mg doses) which I plan to make my last.
I've seen the chart that someone posted online about the number of "clicks" to use for controlling dosages with the Kwikpen. So I'm wondering if I ought to decrease the dosage, increase the dosage timing or both?
If I decrease dosages I could taper down to a 5mg dose in 7 weeks (12.5, 12.5, 10.0, 10.0, 7.5, 7.5, 5.0). Or I could increase the timing of the 15mg doses (10 days, 14 days, 14 days, 18 days).
I should add that I am putting together a new diet and exercise plan which I am taking very seriously and believe I'll be able to stick to it. If the "food noise" becomes a problem then I still have a few refills left and can splurge for another month if I have to.
Also, I realize that this is Reddit and not a doctor's office. I am only seeking information.
Appreciate any comments or advice. Thanks.
Hey everyone!
I started Zepbound about 6 months postpartum (about 5 months ago) with my second and have lost all the weight I wanted to. I still have two pens at 7.5 dose but want to wean off to 5 and then 2.5 after that. I do want to be off it eventually.
I am concerned about gaining the weight back. I exercise and eat well but have a large appetite which is why this has been a game changer. How has your experience been with keeping the weight off long term?
Also bonus question: I started losing a ton of hair! I didn’t have this issue at all for the last few months but it’s suddenly crazy.
Anyone else?
I started my GLP1 journey 8 weeks back.
Started with 0.25mg - Noveltreat by Sun Pharma. Did total 4 weeks on 0.25
Jumped to 0.5mg for next 3 weeks.
Now on 1mg from last 2 week - switched to Semaglyn from Zydus.
I did not responded to GLP 1 in any way. No hunger suppression, no side effects, no fullness. I feel a little upset in my stomach when I wake up. I had to take Pan D a lot as I experienced gas build up on few random days.
How much further should I try on GLP 1. Should I complete 1mg for 4 weeks and stop if not successful or Should I further jump to 1.7mg to keep on testing.
My Endo says it happens sometimes and as per him next alternate is going to Trizepatide. I really don't want to move to Trizepatide as they are out of my budget.
Any help is appreciated.
Been on Mounjaro since the start of this year 2.5 for two months, 5 for a month (suited me the least), then 7 since May. I've lost a decent amount but I'm nowhere near my goal weight. The 7 is working, but I've had enough of the side effects.
The post-injection fatigue and upset stomach have worn me down. I've always had a sensitive stomach and now it's sensitive x100. It's not even the obvious triggers, I've cut out fatty and spicy food completely. Two weeks ago I ate a high fibre meal (sweet potato, beans, broccoli and other veg, chia seed water) two days running and it gave me the worst stomach ever which was also my breaking point.
My quality of life has genuinely dropped. Some weeks I'm too deep in the side effects to do anything, including working out. I don't get how I'm supposed to be building muscle when 3/7 days I'm too fatigued for the gym or stomach feels off. There are good weeks too but the unpredictableness of it and having missed one too many plans because of an upset stomach has just made me fed up.
I skipped last week's dose because I had an important work event and couldn't risk being tapped out. I should've injected yesterday (Sunday is my usual day) and just couldn't make myself do it. last time I skipped, on holiday, taking it again the following week gave me the worst nausea and fatigue I've ever had. So I'm two weeks out from my last injection and honestly I don't want to go back.
I've seen people on this sub keep the weight off after stopping. But my question is about continuing to lose, not just maintaining. I've convinced myself that if I see my endocrinologist, work on the internal stuff with supplements etc, strength train, walk and play tennis, and follow a strict meal plan, then maybe just maybe I can keep losing without a GLP.
I have pcos and 2 years ago I was taking berberine, inositol and strength training, and was losing significant weight! That stopped though because work became intense and I stopped working out - but I never gained that weight back. That gives me hope that maybe if I follow that path again and with a meal plan this time and stricter discipline and regular consultations with an endocrinologist for hormonal support, I won’t need a glp.
So: am I being too naive/stupid? 🥲
I lost about 40 pounds since end of January/beginning of February when I started Reta.
I have a feeling I may need to micro-dose since I had such a hard time before with weight loss. Unless whatever wasn’t working has gotten better with Reta.
I’m using HRT and had changed companies / dose/changes to injections about two or three weeks ago and added testosterone. I think the dose I was being given before had increased my weight, but I was still having trouble for a long time before I started HRT losing weight. The typical menopause “no matter what I did nothing worked”. Weights/cardio, moderate to low carbs, no sweets, following 1 gram of protein per lb of goal weight. Thyroid borderline low and need to retest in 1 month.
I’m really concerned about lowering my dose and potentially gaining weight. I’m currently at 8 mg. I had stalled about two months ago…I think at 6 mgs. So, not sure what to expect and wanted to hear what has worked for others to maintain your goal weight?
I did Reta for 4-5 weeks and love the lower inflammation etc. I only did 0.5mg a week and had to stop because I got extremely constipated. I have never had constipation issues in my life. That being said I have a host of health issues which probably have contributed to my side effects.
I have to be really hydrated or else I will get constipated. I have had a good 3-4 weeks now where I am kind of drinking my pureed ground beef. Last few days I have not had that much water in my meat puree soup and now I am constipated again.
How long does this last?
As I said I have never ever had any issues with this prior to those 4-5 weeks on Reta...
I subscribed to month 1 at 89 for altrx and suddenly they charged me twice on month 2. support said one was the standard rate and the other was a processing fee. never saw that fee when i signed up.
has anyone else faced this. looking to switch somewhere with flat fees and no hidden charges. also need a provider that has NAD+
24F, 5’7”, 135-140 lbs
I stopped microdosing tirzepatide about two months ago. The food noise has definitely come back, but for the most part it’s been manageable. Since I’m trying to maintain my current weight/body composition without tirz, I recently decided to get both an InBody scan and a DEXA scan so I could have some objective numbers to use as a reference point going forward or even improve upon.
Now, I just feel confused and even slightly discouraged with the massive difference.
My InBody scan put me at 21.2% body fat, while my DEXA scan put me at 31.4% body fat.
I understand that these are completely different methods of measuring/estimating body composition and that neither is going to be perfectly accurate, but I genuinely don’t know what to do with such a huge discrepancy. In terms of finding a good reference point to keep track of my progress, getting both scans wasn’t very helpful. It only confused me more, lol.
What’s more confusing isn’t just the difference between the two numbers, but the conflicting information I keep finding when I try to research what a “healthy” body fat percentage is for women. Body fat charts and reference photos online often describe ~31–32% as above average, “poor,” or even overweight depending on the source. I really don’t feel like those descriptions—or the reference images—match what I see in the mirror, which makes the DEXA result even more confusing and hard to reconcile.
I’ve attached both scan results as well as the most recent photos I have of my body for context.
I’d love to hear from anyone who has had both DEXA and InBody/BIA scans done. Were your results this dramatically different? Which measurement did you find more useful for tracking your body composition over time?
I knew it would happen, or more like I had a very strong feeling it would happen, and planned for this just in case it did. My insurance has been covering Zepbound since January, only paying $25 per month. My PA expires August 25 and in February I saw that zepbound coverage had changed from “covered with prior authorization” to “covered after failed step therapy.” So now they want me to go off Zepbound and try and fail phentermine for 6 months before they’ll approve Zepbound again. I am in maintenance, have been for only a month, and I don’t want to fail phentermine because that means I would need to regain weight in order to get back on Zepbound. I’m disappointed but not surprised. Back in February I started coming up with a plan. I began taking my dose every 8 days. Then every 9. Then every 10. I’ve been filling my prescription every 21 days and the last four fills I requested a lower dose than what I’m currently on. Now I have 3 pens of 7.5mg, 8 pens of 5mg and 8 pens of 2.5mg in my fridge. I will use these to tapper off slowly over the course of 4-6 months. If it doesn’t work I will look into other options because I can’t pay for this out of pocket but I want to try to come off first. I’m not really looking for tips on how to fight my insurance on this. I’ve spoken to over 10 different people and spent countless hours on the phone. I’m done. I need some reassurance and tips on how to navigate this off of Zepbound. For some background, I am a 5’5 female in my 30s. Highest weight was over 215 but not exactly sure. I gained 70 pounds slowly over the course of 10 years of marriage and two pregnancies. I lost 20 pounds on my own and stalled. Started Zepbound at 195 and lost 50 pounds in 6 months, been maintaining at around 145 for a month. Completely changed my diet, started counting calories and macros, cardio 2-3 times a week and strength train 4 times a week. I know people are planning on being on this medication for the rest of their life, but what about those that have come off and kept the weight off. How did you do it?
Also, I posted this on the Zepbound forum yesterday and only received tips and advice on how to continue on a glp. Whether to go on compound, or how to fail phentermine, or how to use my stash until I can get it prescribed again. Not one tip on the advice I specifically asked for. I understand people are coming from a good place, but I want to try to come off. So I’m hoping this is a better place to ask. Thanks in advance.
Stopped reta cold turkey almost 3 weeks ago due to extreme anhedonia. I was only on 2mg a week for about 9 weeks and lost 15lbs.
I’ve been eating at my maintenance according to MacroFactor (2300 calories) for a little over a week now. But these past few days I’ve noticed I’m extremely hungry. Like to the point where all I’m thinking about it how to volumize my next meal and counting the minutes until then. Can anyone give me an answer or estimate to when this will start to go away?
Hi I’m 32 5”11 222 lbs this is the heaviest I ever been and it makes me depressed. I try to work out but it’s difficult with 2 little kids and finding time to work out. I’ve been working out consistently for 3 weeks and I gained weight which made me more depressed. I understand that is not a long time at all. I’m just not sure what to do
Thanks for any and all advice.
This is happening so much quicker than I thought it would. I’ve been eating so much more this past week bc of my cycle starting. The food noise is so back. I started in October 2025 at 268. Took me 9 months to lost 40lbs. Got taken off cold turkey due to medical and insurance reasons. And I’m sliding back exponentially.
I’m hoping to start working out next week. I know I should’ve been doing it all along but I have really bad anxiety and executive dysfunction gnawing at me to stay home.
I gotta reconfigure my macros and make sure I’m staying full. I have a lot of food restrictions so I can’t eat what most would to stay full (whole grains/legumes/seeds/many vegetables and greens).
Idk. I think I’m beyond help at this point and just need to white knuckle it on my own 😭