r/GLPGrad

Started Nov 2025. 45M 5’11” T2D MASH CKD SW:357 CW:235 GW:180

Sometimes I don’t know what to make of this drug. In April, having been at 7.5mg for 4 months I started to experience hunger again. I knuckled through for a few more weeks, continuing to lose weight, and having that hunger signal increase and decrease seemingly without rhyme or reason. In June I made the call to titrate to 10mg, and last week started. Second dose was today and I’m RAVENOUS. My weight also went UP 3 pounds. My activity level has increased, but my daily burn according to Apple Health is unchanged. Should I just need to eat more and stop trying for such a high deficit? What are you guys experiencing when you titrate?

Been off Mounjaro for 8 weeks due to medical surgery. Staring back on 7.5 mg this week. Anyone have similar experiences with being off for a while? If so, how did you do? Did weight loss kick back up? Side effects?

I have never in my life been this bad when it comes to mental health, and I truly believe it's because of the GLP-1 (Ozempic) I've been taking. Some peers of mine and I have been on it for about 4 months and it's caused SEVERE depression, SI, and anhedonia in some of us, and anxiety reduction in others. I'm wondering if anybody else has had mental health side effects from Ozempic? I took my last shot two weeks ago and it's been absolute hell. I think there is an extreme amount in my system since people metabolize the drug differently and the effects are nearly unbearable. Different perspectives would be appreciated. I have honestly never felt this bad in my life out of no where. There is definitely something messing with neurotransmitters created in the gut.

My gastritis started after taking Retatrutide, and it's been a brutal two months. PPIs did nothing for me. I'm currently on sucralfate and H2 blockers; they help a little, but I’m still dealing with heavy bloating after meals, trapped gas, and a burning/tingling feeling between my ribs.

If you got gastritis specifically from a GLP-1 agonist, what helped you recover and how long did it take?

Hello everyone. I am thinking to start Mounjaro. I would like to lose 7-9 kg. However I have a lot of food noise going on and I would like to eat more intuitively rather than counting every single calorie. Taking GLP will mean being forever tied to accurate calorie counting? Is there anyone who managed to keep the weight off without maintaining a rigid attitude?

Thank you!

One that’s easy or efficient?

Can those of you who’ve had positive experiences with tirzepatide share them?

I have severe health anxiety and panic attacks, and I find myself constantly reading the scary posts on here about things like gastroparesis and other serious side effects. I know people are more likely to post when something goes wrong than when everything is going well, but my anxious brain tends to forget that.. because of my health anxiety, my brain latches onto those stories and starts convincing me that the worst-case scenario is going to happen to me too. I think being in compound versus name brand makes me particularly anxious as well… since the compounded meds aren’t as well regulated. Anyways…

I’d really appreciate hearing from people who’ve had a positive or uneventful experience. I’m just trying to shift my focus and remind myself that the worst-case scenarios aren’t the only outcomes. Thank you. ❤️

Hello everyone. I am thinking to start Mounjaro. I would like to lose 7-9 kg. However I have a lot of food noise going on and I would like to eat more intuitively rather than counting every single calorie. Taking GLP will mean being forever tied to accurate calorie counting? Is there anyone who managed to keep the weight off without maintaining a rigid attitude?

Thank you!

Hi there! I’m three months off wegovy and have maintained my weight loss since stopping. In order to maintain, I’ve been super strict with tracking macros, a little obsessive with exercising and step count and feeling anxious when having a meal out. This feels like a mix between feeling sustainable in order to continue with my goals and like I’m white-knuckling it and one wrong move away from starting to gain.

Has anyone else felt this way/dealt with this? Is it a mindset thing? What advice do you have? I know I have the tools and know what to do but some days it feels like a battle.

2 weeks in GHK-CU but it still stings hours after the administration even though I let it room temp for an hour. Is that normal?

Hey, y’all. I am NOT asking for medical advice here but maybe just lived experience? Hubby and I want a kid, so I am getting off my GLP-1 for now. I have lost about 55lbs over the course of 7 months and have maintained that at a low dosage. I am confident I can maintain healthy habits, especially since my ADHD being untreated causes 99% of my weight gain from binging (eating as a stim). Now that that’s being treated, I’m not as worried. But I am TERRIFIED I will gain it all back. 😭 Has anyone has success? I will probably return to a maintenance dosage after I’m done having babies, because I do have PMOS, and presumably will for the rest of my life. And I do know that this medication is controlling my metabolic issue as well. But is there anything I can do in the meantime? Should I titrate down or go off cold turkey?

I’m experimenting with the idea of trying to taper off Zepbound, but definitely have questions. I was overweight since before puberty (say 40 years) and have been at goal for a year and a half on 5 mg Zepbound every 10 days. I exercise and have a healthy diet but I worry about going back to feeling hungry all the time and battling the food noise with constant calorie counting. Trying to get some data since haven’t seen any studies really addressing long term success.

5 months, 23kg lost and a body rebelling against going any further; today was my final 10mg shot. Now for the hard part…….

Has anyone had to increase their dose in maintenance after a substantial period of time? After reaching goal (30 lbs lost) on a max dose of 11 mg tirzepatide, I’ve been successfully maintaining on 8 mg for the past year. Unfortunately, I’m experiencing the return of food noise! Hunger seems to still be in check.

Hi there. I’m a year and a half in on my compounded sema and more recently compounded triz journey. I started at almost 235 but have been hovering around 195 for a while. I workout semi-regularly and there are other things I can fine tune to be successful in maintaining and continuing on. I would like to stop the medication. Not cold turnkey, but wean myself off. Can people share with me their success stories with keeping weight off and even continuing their weight loss?

I have noticed I have not an ounce of food noise and struggled with that prior to starting the meds. While I know that will come back, I want to work on more things to discipline myself.

I've been on semaglutide for 2.5 years and have lost and maintained 70 pounds. Lately the idea of protein powder makes me want to barf. That fake taste, artificial sweetener, I just can't do it anymore. Oddly enough, I find I actually eat more when using it because I'm not satisfied with these meals. I want to try a more whole food diet. I lift weights and have actually gained muscle in the past 2.5 years so I'm not too worried about protein but do need to get more fiber. What are y'all eating? And how are you breaking up your calories/meals? I read eat like a king in the morning, a prince at noon and a pauper at night.

I started my journey in July 2023 very slowly working my way up the ladder with Wegovy. I stayed at each dose for 2-3 months at a time and never made it to the top, had to back off due to stomach pain around injection day so the highest I made it was 1.7mg.

In the winter of 2024-2025 ish I switched over to Zepbound. Unrelated to everything else I’m about to talk about, I loved Zepbound for less side effects and it helped me brake a full stall out I was having, but I ended up having some strong rib and back pain that sent me to the ER a couple times. Fast forward 6 months and I switched back to Wegovy and the pain went away; Zepbound was somehow causing costochondritis (if anyone has questions about that I’m happy to dive in, this just isn’t the main part of my story so I’m going to push past it). I was on 1mg of Wegovy from summer 2025 until March 2026 when I decided to come off I was on the 0.5mg dose.

I had full plans to do a taper but after 3 years of fighting my pharmacy about filling meds I wasn’t able to get a box before leaving on a 3 week vacation so I said meh I’ll just take the lowest dose when I get back. But 3 weeks went by on vacation, paired with the 10 days I couldn’t get my meds before my trip, and when I got home I filled my meds finally hit decided not to take them, I felt really good. I was 1 month off the meds and thought, I feel great, I think now is time to come off.

For the first 45 days off GLP1 I felt great. Around day 40 I started getting some stomach burning and a really crazy uptick in bowel movements. They were healthy, but more frequent, and paired with just strange discomfort like I had a stomach ache but really didn’t. A week later the abdominal burning got bad enough to where I thought I had gastritis so I picked up some Pepcid from the pharmacy and started taking it every morning. I found that it helped quiet symptoms but under the surface I could tell my stomach was getting worse, it wasn’t getting better. At this point it’s been 2+ weeks of pain and I’m correlating it to everytime I eat, I would get really intense abdominal burning 1-3 hours after eating, it was NOT instant. Some nights it was so painful I would consider going to the ER. The only thing that helped shut it down was combined pepto and mylanta after about 30 minutes. I did not have heart burn, the burn was low in my abdomen and centralized, I never felt any reflux. During this my bowel movements were totally normal: not loose, no constipation, soft, no weird color or smell, and I was going 1-2 times a day.

I saw my doctor and got a rental to GI, they booked an upper endoscopy. They thought they were going to see gastritis and so did I. I took a bunch of fecal tests as well in case it was a parasite from traveling. Scope came back negative, fecal tests showed nothing, and I had an ultrasound on my gallbladder that was normal. My GI booked a gastric emptying test and one morning I ate my radioactive eggs, got my x rays every hour for 4 hours, and went on my way. At my follow up apt a week later my doctor walked in and said you have gastroparesis.

Food is the trigger so at this point it’s been 8 weeks (thank you American healthcare) and I’ve lost 10lbs from not being able to eat as I should. I found 5 foods worked to keep the pain minimal so every single day I would eat the same meal: plain GF oatmeal for breakfast (I am not GF but my husband by accidentally bought a box and my body liked it so it stayed on the safe list), boiled chicken tossed with Greek yogurt (the saddest chicken salad of my life), and for dinner a baked sweet potato with ground beef and more Greek yogurt. I ate this meal plan every single day for 6 weeks straight and just about lost my fucking mind.

My gastroparesis is mild. I do not have the horror story everyone talks about on these threads or in news articles. I do not have nausea. I am not vomiting. I am not constipated. I do have abdominal pain/burning after everything I eat because the food is sitting longer than it should and my stomach is creating more acid to try to digest it and move it along which is why the Pepcid has been helpful for pain but it’s not actually fixing anything. I was prescribed a motility medication, Reglan, which I start today.

I asked my doctor if this was permanent or long term and she said it could be either, but one thing she knows is that she’s seen A LOT of it recently and in that group of people, a good amount were previously on a GLP1.

I did not have gastro issues before starting wegovy. I did not have gastroparesis. I am deeply deeply sad. I have such mixed emotions because it changed my life; I lost 70lbs, I was a prisoner in my body and now I am literally a fitness instructor. I was deeply depressed, dead in the water with my anxiety and OCD, unable to move my body most days and now I can’t imagine skipping more than a couple work outs or any of my outdoor hobbies now. I feel like a new person. But I also feel like I made a deal with the devil.

I read all the warnings just as yall did and I gambled. At NO point on wegovy or Zepbound did I think I was developing gastroparesis. Did I fight constipation during my time? Yes. Was it managed? Yes. Did I go through sulfur burps at the beginning? Yes. Were there days I felt like I ate too much and food was fermenting in my stomach? Yes. But those days were scarce compared to the good days I had for 3 years. I literally never saw this coming.

Anyways this is long winded so if anyone has questions I’m around.