u/GLP1Trintillix

I wanted to share this in case it helps someone else connect the dots, because it took me way too long to figure out what was going on.

I’ve been on a GLP-1 (Mounjaro) for about 2 years and had a really solid response initially — appetite suppression, earlier satiety, the whole “food just isn’t that interesting anymore” effect. Nothing dramatic recently, but it was working in a steady, predictable way.

Then I started Trintellix.

Over time, I noticed:

- My appetite creeping back in

- Losing that early fullness feeling

- Eating more without that “automatic stop” signal

- Gradual weight gain (about 20 lbs over the time I was on it)

At first I blamed everything else — stress, routine, diet. But the pattern didn’t really make sense because nothing else had changed that much.

I tapered off Trintellix recently and… it’s honestly kind of shocking. Within weeks, I started noticing:

- Earlier satiety again

- Reduced interest in food

- That familiar GLP-1 “quieting” effect coming back

It feels like the GLP-1 is actually working again.

I know this is anecdotal, and I’m not saying this is a universal thing, but the timing is hard to ignore. My guess is that something about Trintellix was counteracting the appetite/satiety signaling — maybe serotonergic effects or something central that overlaps with GLP-1 pathways.

Curious if anyone else has experienced:

-Reduced effectiveness of Mounjaro/Wegovy while on Trintellix

-Weight gain or loss of appetite suppression with it

-Or improvement after stopping

Would love to hear if this is just me or a real pattern

I wanted to share this in case it helps someone else connect the dots, because it took me way too long to figure out what was going on.

I’ve been on a GLP-1 (Mounjaro) for about 2 years and had a really solid response initially — appetite suppression, earlier satiety, the whole “food just isn’t that interesting anymore” effect. Nothing dramatic recently, but it was working in a steady, predictable way.

Then I started Trintellix.

Over time, I noticed:

- My appetite creeping back in

- Losing that early fullness feeling

- Eating more without that “automatic stop” signal

- Gradual weight gain (about 20 lbs over the time I was on it)

At first I blamed everything else — stress, routine, diet. But the pattern didn’t really make sense because nothing else had changed that much.

I tapered off Trintellix recently and… it’s honestly kind of shocking. Within weeks, I started noticing:

- Earlier satiety again

- Reduced interest in food

- That familiar GLP-1 “quieting” effect coming back

It feels like the GLP-1 is actually working again.

I know this is anecdotal, and I’m not saying this is a universal thing, but the timing is hard to ignore. My guess is that something about Trintellix was counteracting the appetite/satiety signaling — maybe serotonergic effects or something central that overlaps with GLP-1 pathways.

Curious if anyone else has experienced:

-Reduced effectiveness of Mounjaro/Wegovy while on Trintellix

-Weight gain or loss of appetite suppression with it

-Or improvement after stopping

Would love to hear if this is just me or a real pattern.