u/Leelah_Sprite

Hello,

I've learned from a gene test that I am a poor metabolizer of the CYP2D6 enzyme. First-line treatments for tardive dyskinesia (TD) are VMAT2 inhibitors (valbenazine and deutetrabenazine) and CYP2D6 is the metabolising enzyme.

Is anyone else a poor metabolizer of CYP2D6 enzyme that is required to metabolise the treatments for TD?

Has anyone tried treatment even though you are a poor metaboliser of the VMAT2 inhibitors (valbenazine and deutetrabenazine)? What was your experience? Did you get many side effects?

I'm awaiting an official diagnosis of TD from a neurologist but now I am petrified of taking the drug to help my TD and getting terrible side effects.

Hi,

42F recently switched to Zoloft from Lexapro. I was successfully on Lexapro for 21 years until I started getting terrible panic attacks and health anxiety. My GP said the lexapro isnt working anymore and time for a change. Here is what we did:

Wk 1 and 2 reduced Lexapro to 15mg

Wk 3 reduced Lexapro to 10mg

Wk 4 Added 50mg Zoloft along with the 10mg Lexapro

Wk 5 dropped the lexapro completely - continue on 50mg Zoloft

Wk 6 50mg Zoloft

Wk 7 upped zoloft to 100mg

Wk 8 zoloft 100mg

Wk 9 zoloft 100mg

Wk 10 zoloft 100mg

I've been on Zoloft for 6 weeks total

From the very start of taking zoloft side effects were prominent. Fatigue, nausea, headaches, morning anxiety.

My anxiety increased as to be expected and take 1mg Lorazepam to help get me through.

But by mid week 9 my anxiety has evolved into addrenalin surges first thing when I wake up, followed by nausea, and intense body convulsions that could almost be mistaken for a seizure. They are intense, scary and hurt as my body tenses and limbs convulse.

I went back to my GP and she wants me off Zoloft but first reduce to 50mg for a week and then switch to a different medication. My GP wants me to change to Effexor which Im hesitant to do due to its side effect profile and terrible withdrawal if I have to come off it if it doesnt work.

Im hoping to get some perspective on this and whether I should try and stick it out a bit longer with Zoloft despite the convulsions and hope it subsides as a side effect, or do I change my medication as my doctor is concerned about these convulsions. I know I should always listen to and follow my doctors advice first, but i guess what im really seeking an answer to is if these convulsions are normal and will subside. The closest I've read from peoples experiences is tremmors of the hands, arms or feet. What im experiencing is a full body attack however its not a seizure. Has anyone else experienced this? Did it get better?

Since my last visit to the GP, I've been in a deepdive online looking at Effexor, as well as other options Prozac, Paxil and Pristiq. I've been researching and reading as many posts from users sharing their experience with these drugs just to get a get a better idea before going back to my GP and deciding on what next.

Thanks heaps

Hi, reddit community,

I've stumbled across dexlansoprazole (dexilant) in this community and wondered if it might work better for me instead of pantoprazole.

I deal with horrible morning nausea that my gastroenterologist thinks is caused by GERD. I take 20mg of Pantoprazole at night before my dinner. It has helped with the burning, but I still get the horrible morning nausea that has now escalated into anxiety and panic attacks because I'm just not coping with the nausea.

Does anyone have any experience with dexlansoprazole (dexilant) and if it might work better to alleviate this morning nausea.

I should also add I have been on SSRI (Lexapro) for 21 years. My GP has just changed me to a different SSRI (zoloft) as my anxiety has been out of control due to not coping with the nausea. I am aware of the gut brain axis and is definitely a co factor.

Thanks