u/Snoo_45651

I’m 38 years old and had a TFMR for T21 at 16 weeks on July 23, 2025. We took a five-month break afterward, and I started trying to conceive again in December 2025.
This is now my 5th TTC cycle since then. In January, I had a brief chemical pregnancy, but since then I’ve had no positive tests.
I do have a healthy son who was born in 2017 when I was 29.
My new OB-GYN told me to come back after six months of trying if I’m not pregnant. I appear to be ovulating regularly (positive OPKs, regular cycles), my progesterone levels have been normal, and my AMH was 3.3. I do have a history of PCOS, so I understand that AMH may be somewhat elevated because of that.
My questions are:
At age 38, after five cycles of trying and one chemical pregnancy, would this be considered infertility?
What kinds of tests or treatments did your OB-GYN or RE recommend in a similar situation?
If you were not interested in IVF, what other options were offered?
Did anyone conceive naturally after a TFMR and several unsuccessful cycles?
I’m not mentally or physically ready to pursue IVF, so I’m trying to understand what less aggressive options might be available and what is reasonable to expect at this stage.
Emotionally, this process has been very difficult. I’m still grieving the TFMR, and I’m also wrestling with whether I truly want to continue trying for a second child. I’ve reached out to TFMR-specific support because general therapy hasn’t felt very helpful.
I would really appreciate hearing from others who were TTC at 38+ after TFMR and what your next steps looked like

I don’t know when to stop this whole thing and call One and Done

I had emotionally given up after last cycle, but we still timed things well this fifth cycle TTC. (TFMR July 23rd 2025 for T21 when I was 37. First kid turns 9, this August)

I recently turned 38, and I’m carrying a lot of regret about delaying our second pregnancy. When I was 34, I wanted to try sooner, but my husband was indecisive, and comments from my mother-in-law about how we “couldn’t manage a second child” made me doubt myself.

I truly thought this might be our cycle, but it’s now clearly negative.

Yesterday, I saw a neighbor walking with her 4-month-old baby and husband. Her timeline closely matches what mine would have been if I hadn’t gone through TFMR, and she also has a first child the same age as my son. I was driving by and pretended not to see them. They probably thought I was rude since I never really checked in during her pregnancy or after delivery.

She posts casually in our common groups, and while I know she’s done nothing wrong, it still hurts. It feels like pregnancy and growing their family came so easily for others, while I’m stuck in this cycle of hope and disappointment.

I’ve become increasingly antisocial. I don’t even know what I’m expecting from life anymore. For a long time, I convinced myself I was okay being one-and-done, but I still can’t fully accept that possibility.

Therapy hasn’t been very helpful for me. It feels too general-focused on “feeling your feelings” without truly understanding the unique grief and trauma of TFMR.

I’m not sure what I’m looking for by posting this. Maybe just to know that someone else has felt this way.

If anyone is on a similar timeline, or has experienced convincing symptoms that still ended in a negative test, I’d really appreciate hearing from you.

I thought I was experiencing promising signs this cycle, but once again my body feels like it fooled me.

I’m exhausted. I feel cursed.

Turned 38, 7 DPO, and feeling emotionally exhausted after TFMR for T21

I’m currently 7 DPO in what is technically our 5th TTC cycle after a TFMR for T21 at 16 weeks in July 2025.

I conceived that pregnancy right around my 37th birthday. I’ve now turned 38, and I honestly don’t know what to expect anymore.

I have a healthy son who turns 9 in August, and he is my world. I’m living for him, and I know how blessed I am to have him. But I’m still struggling deeply with the loss and with the uncertainty around trying for a second child.

This cycle almost didn’t happen because I had mentally decided to stop after last cycle (our 4th cycle TTC after the TFMR). But we tried again, and now I’m stuck in the two-week wait feeling anxious, pessimistic, and emotionally raw.

Yesterday I went to a gathering where women were casually talking about ideal age gaps between siblings-2 years, 3 years, and someone pointed out my 9-year age gap. Everyone was chatting happily, while I was sitting there feeling like I had no control over how my life unfolded.

I also avoided calling one of my husband’s close friends who recently delivered her baby.who came to our neighborhood and wanted to just briefly visit . I was 12 weeks pregnant with my TFMR pregnancy at the time of her baby shower. Seeing babies and pregnancy announcements (especially around the coinciding timelines ) still feels incredibly triggering.

I’m carrying a lot of resentment because my husband was very indecisive about having a second child, and I feel like those lost years mattered. I know dwelling on that doesn’t change anything, but it’s hard not to think about.

I feel like only a healthy pregnancy outcome will fully heal this wound, but at the same time I’m terrified of going through another bad outcome. I don’t feel optimistic. Part of me wants to put a full stop to TTC and accept being one-and-done. Another part of me is not ready to let go.

I’m probably 60% mentally prepared to stop, but the grief is still very raw, and I suspect this will take years to fully heal.

Has anyone else felt this conflicted after TFMR?

Hi everyone,
My frd recently graduated with a degree in Biomedical Engineering and is interested in starting a career in data analytics, ideally in healthcare/pharma, but she is also open to analytics roles in other industries.
She has completed a short data analytics course covering:
SQL
Excel
Python (pandas, NumPy, Jupyter)
Power BI/Tableau basics
She is currently building projects and creating a GitHub portfolio and apply for remote volunteer opportunities to gain practical experience.
We’re trying to understand what has actually worked for recent graduates (2025–2026 pass-outs) in today’s market.
A few questions:
What strategies helped you land your first data analyst role?
How important are GitHub projects versus certifications?
Are Forage, Kaggle, or volunteer projects valued by recruiters?
Should she focus on healthcare/pharma companies like Pfizer and IQVIA, or apply broadly across industries?
Are there specific companies in India (especially Chennai) that are hiring freshers for data analyst roles?
Any tips for networking or reaching out to professionals on LinkedIn?
Any guidance, success stories, or leads would be greatly appreciated.
Thank you!