u/Snoo_45651

I’m currently 6 weeks 4 days pregnant after a TFMR last year, and my first ultrasound is next week. I’m finding that instead of feeling excited, I mostly feel numb. I don’t really know what I’m walking into emotionally.
I’m trying to be realistic rather than expecting to feel “safe” right away. In my mind, I keep thinking maybe I’ll start feeling more confident after a reassuring heartbeat, then a low-risk NIPT, then good scans (NT/early anatomy, anatomy scan, fetal echo if indicated, growth scans, etc.). But then I read stories here of unexpected findings much later in pregnancy ,even into the third trimester-and it makes me wonder if I’ll ever truly relax.
For those who have been pregnant after a TFMR, when did you personally start to feel that things were likely going well? Was there a particular milestone that helped you breathe a little easier or feel comfortable sharing the pregnancy with family and friends?
I know none of us get guarantees, but I’d really appreciate hearing what helped you emotionally after everything you’d been through.

Personally, I keep thinking that if I make it through a reassuring heartbeat, low-risk NIPT, normal scans, and everything continues to look good through around 28 weeks, I might finally be able to let myself believe this is real.
I know many people will say to stay optimistic, and I truly understand that perspective. For me, after a TFMR, I’m trying to balance hope with realistic expectations. In reality, after reassuring NIPT and all the recommended scans up to around 28 weeks, how much confidence did you personally feel?

I tried La Roche-Posay Anthelios Ultra-Light Fluid Mineral Face Sunscreen with Zinc Oxide SPF 50 and Innisfree Mineral Sunscreen, but I still wanted to check with you all-what do you recommend as the best pregnancy-safe sunscreen?

Hi everyone, I’m 38 and currently 4w6d based on LMP. Apart from occasional headaches (which could just be dehydration) and some intermittent lower abdominal sensations, I’m hardly having any symptoms. Some days I feel nothing at all.
This is my third pregnancy overall, but my first was almost a decade ago, so I honestly don’t remember what early pregnancy felt like. I also had a second-trimester loss last year, which has made me extra anxious this time around.
I know symptoms (or lack thereof) don’t necessarily mean anything, but I’m feeling a little panicky while waiting for my first ultrasound at 7w2d.
Anyone around 4–5 weeks and not experiencing many symptoms? When did your symptoms start, if at all? What symptoms to expect in the next few weeks
Thanks ❤️

My OB is planning to do Myriad NIPT at 8 weeks. Has anyone in this sub had Myriad Prequel drawn that early and received a result with enough fetal fraction on the first draw?
Would there be any advantage to waiting until 9 weeks to reduce the chance of a redraw, or are 8-week draws generally reliable in your experience?
Looking for others’ experiences and feedback. Thanks 😊

My OB is planning to do Myriad NIPT at 8 weeks. Would there be any advantage to waiting until 9 weeks for a higher fetal fraction and lower chance of a redraw, or are 8-week draws generally reliable? Looking for others’ experiences. Has anyone taken it in your sub ? Need some feedback

Thanks 😊

Hi everyone,

I’m 38 and currently trying to conceive again after a TFMR last year at 16 weeks due to a severe T21 pregnancy with multiple defects that were considered non-viable. Genetic testing afterward showed it was a de novo event. I also have a healthy 9-year-old son.

I’m wondering if anyone here had a similar experience in their late 30s (especially 37–40) and went on to have a healthy pregnancy and baby afterward. I’m finding this journey emotionally difficult and would really appreciate hearing any positive stories or happy outcomes.

Thank you for sharing.

38F with PCOD and increased AMH (3.3) because of it

Did anyone take Clomid primarily to improve follicle/egg recruitment and increase the chances of conception, even though they were already ovulating?

If so, did you end up with a singleton pregnancy or twins? I’m especially interested in hearing from anyone with PCOS/PCOD who took the starting dose of 50 mg.

My OB-GYN mentioned Clomid as a possible next step if I don’t conceive naturally, and one of my biggest risks stated is the possibility of twins. I’d love to hear about your experiences and whether the treatment helped.

Hi everyone, regular poster here.

I recently posted about my new OB-GYN, who was incredibly supportive after my TFMR and honestly was one of the reasons I found the courage to try to conceive again. Unfortunately, she is leaving the practice, and I have an appointment with her tomorrow.

For context, I had a TFMR for de novo T21 at 16 weeks in July 2025. I took a 5-month break afterward and have now been trying to conceive again for 6 cycles. I had one chemical pregnancy in January 2026, but otherwise no positive tests.

I am currently in my ovulation window for cycle #6 and feeling very emotional and scared today.

Part of me wonders how long I should keep trying. Part of me is terrified of another bad outcome. Part of me worries that because I’m now 38, all of my eggs have suddenly become “bad,” even though I know that’s probably not how it works. My AMH was reassuring (3.3 possibly influenced by PCOS), I seem to ovulate regularly, and I don’t feel like there is anything obviously wrong.

I have an appointment with my OB-GYN tomorrow and honestly don’t know what to expect. I’m worried that if this cycle doesn’t work, I’ll be looking at more testing, procedures, fertility treatments, or discussions about IVF. I don’t even know what questions I should be asking. I’m scared of IVF given as an option. I’m totally drained already.

What I’m really looking for today are stories from people who were 38+ after TFMR for T21 and went on to have healthy pregnancies. Did anyone have an uncomplicated pregnancy after all the fear and anxiety? Did anyone feel convinced they were running out of time and then go on to have a good outcome?
Lately I’m having lower back pain , not sure if that’s normal during fertile window. I’m scared of what’s ahead.

I know reassurance can’t predict my future, but I’m having a hard day. Sometimes I feel like only a positive experience can soften the memories of what happened last year. I used to be such a happy person, and I sometimes wonder if I’ll ever feel like myself again.

Any experiences, advice, or encouragement would mean a lot. 🤍

38 years old - 6th TTC cycle after TFMR for T21. Trying naturally vs IUI vs IVF with PGT-A? What would you ask your OB-GYN next?

Hi everyone. I turned 38 recently and I’m a regular poster here. I’m now entering my 6th cycle trying to conceive after my TFMR.

For context:
I had a TFMR for de novo T21 at 16 weeks on July 23, 2025.
I conceived that pregnancy naturally right when I turned 37.
We took a 5-month break afterward before trying again.

Since then I’ve been taking CoQ10, inositol, prenatals, exercising, and trying to take good care of myself.

I had one chemical pregnancy in my first TTC cycle after the break, but otherwise no positive tests.
My OB-GYN had initially asked me to come back after 6 unsuccessful cycles if I was not pregnant. Unfortunately, now I found out she is leaving the practice, which honestly upset me because she was very supportive and gave me hope after my TFMR.

My husband, who was initially hesitant for years about a second child, is now suddenly serious about IVF because of PGT-A testing and reducing chromosomal abnormality risk. But I am very hesitant about IVF because of the emotional, physical, and financial strain.
Part of me feels maybe I should continue trying naturally for a few more months, or maybe consider IUI first. My previous plan with my OB-GYN was:
early Myriad NIPT at 10 weeks,
regular OB follow-up,
MFM scans at 12 and 16 weeks,
detailed anatomy scan at 20 weeks,
to catch issues early if I conceived naturally.
So I’m trying to understand what direction makes the most sense at 38 after TFMR.

My questions:

1. For people in the U.S. - how much did IVF with PGT-A approximately cost, and was any part covered by insurance?
2. Did anyone here choose natural conception at 38+ instead of IVF after TFMR? Any regrets either way?
3. Is IUI worth considering before IVF if I seem to ovulate regularly and have conceived naturally before?
4. For those who met with an OB-GYN or RE after 6 months TTC at a similar age, what testing or action plan was suggested?
5. What questions should I ask my OB-GYN before she leaves and transfers my care to another doctor?
   Emotionally, I still feel that without a future positive experience, my TFMR memories remain very raw. At the same time, I’m terrified of another bad outcome.
   I have a healthy son who turns 9 this August.

Any advice or experiences would really help. Thank you 🤍

I’m 38 years old and had a TFMR for T21 at 16 weeks on July 23, 2025. We took a five-month break afterward, and I started trying to conceive again in December 2025.
This is now my 5th TTC cycle since then. In January, I had a brief chemical pregnancy, but since then I’ve had no positive tests.
I do have a healthy son who was born in 2017 when I was 29.
My new OB-GYN told me to come back after six months of trying if I’m not pregnant. I appear to be ovulating regularly (positive OPKs, regular cycles), my progesterone levels have been normal, and my AMH was 3.3. I do have a history of PCOS, so I understand that AMH may be somewhat elevated because of that.
My questions are:
At age 38, after five cycles of trying and one chemical pregnancy, would this be considered infertility?
What kinds of tests or treatments did your OB-GYN or RE recommend in a similar situation?
If you were not interested in IVF, what other options were offered?
Did anyone conceive naturally after a TFMR and several unsuccessful cycles?
I’m not mentally or physically ready to pursue IVF, so I’m trying to understand what less aggressive options might be available and what is reasonable to expect at this stage.
Emotionally, this process has been very difficult. I’m still grieving the TFMR, and I’m also wrestling with whether I truly want to continue trying for a second child. I’ve reached out to TFMR-specific support because general therapy hasn’t felt very helpful.
I would really appreciate hearing from others who were TTC at 38+ after TFMR and what your next steps looked like

I don’t know when to stop this whole thing and call One and Done

I had emotionally given up after last cycle, but we still timed things well this fifth cycle TTC. (TFMR July 23rd 2025 for T21 when I was 37. First kid turns 9, this August)

I recently turned 38, and I’m carrying a lot of regret about delaying our second pregnancy. When I was 34, I wanted to try sooner, but my husband was indecisive, and comments from my mother-in-law about how we “couldn’t manage a second child” made me doubt myself.

I truly thought this might be our cycle, but it’s now clearly negative.

Yesterday, I saw a neighbor walking with her 4-month-old baby and husband. Her timeline closely matches what mine would have been if I hadn’t gone through TFMR, and she also has a first child the same age as my son. I was driving by and pretended not to see them. They probably thought I was rude since I never really checked in during her pregnancy or after delivery.

She posts casually in our common groups, and while I know she’s done nothing wrong, it still hurts. It feels like pregnancy and growing their family came so easily for others, while I’m stuck in this cycle of hope and disappointment.

I’ve become increasingly antisocial. I don’t even know what I’m expecting from life anymore. For a long time, I convinced myself I was okay being one-and-done, but I still can’t fully accept that possibility.

Therapy hasn’t been very helpful for me. It feels too general-focused on “feeling your feelings” without truly understanding the unique grief and trauma of TFMR.

I’m not sure what I’m looking for by posting this. Maybe just to know that someone else has felt this way.

If anyone is on a similar timeline, or has experienced convincing symptoms that still ended in a negative test, I’d really appreciate hearing from you.

I thought I was experiencing promising signs this cycle, but once again my body feels like it fooled me.

I’m exhausted. I feel cursed.

Turned 38, 7 DPO, and feeling emotionally exhausted after TFMR for T21

I’m currently 7 DPO in what is technically our 5th TTC cycle after a TFMR for T21 at 16 weeks in July 2025.

I conceived that pregnancy right around my 37th birthday. I’ve now turned 38, and I honestly don’t know what to expect anymore.

I have a healthy son who turns 9 in August, and he is my world. I’m living for him, and I know how blessed I am to have him. But I’m still struggling deeply with the loss and with the uncertainty around trying for a second child.

This cycle almost didn’t happen because I had mentally decided to stop after last cycle (our 4th cycle TTC after the TFMR). But we tried again, and now I’m stuck in the two-week wait feeling anxious, pessimistic, and emotionally raw.

Yesterday I went to a gathering where women were casually talking about ideal age gaps between siblings-2 years, 3 years, and someone pointed out my 9-year age gap. Everyone was chatting happily, while I was sitting there feeling like I had no control over how my life unfolded.

I also avoided calling one of my husband’s close friends who recently delivered her baby.who came to our neighborhood and wanted to just briefly visit . I was 12 weeks pregnant with my TFMR pregnancy at the time of her baby shower. Seeing babies and pregnancy announcements (especially around the coinciding timelines ) still feels incredibly triggering.

I’m carrying a lot of resentment because my husband was very indecisive about having a second child, and I feel like those lost years mattered. I know dwelling on that doesn’t change anything, but it’s hard not to think about.

I feel like only a healthy pregnancy outcome will fully heal this wound, but at the same time I’m terrified of going through another bad outcome. I don’t feel optimistic. Part of me wants to put a full stop to TTC and accept being one-and-done. Another part of me is not ready to let go.

I’m probably 60% mentally prepared to stop, but the grief is still very raw, and I suspect this will take years to fully heal.

Has anyone else felt this conflicted after TFMR?

Hi everyone,
My frd recently graduated with a degree in Biomedical Engineering and is interested in starting a career in data analytics, ideally in healthcare/pharma, but she is also open to analytics roles in other industries.
She has completed a short data analytics course covering:
SQL
Excel
Python (pandas, NumPy, Jupyter)
Power BI/Tableau basics
She is currently building projects and creating a GitHub portfolio and apply for remote volunteer opportunities to gain practical experience.
We’re trying to understand what has actually worked for recent graduates (2025–2026 pass-outs) in today’s market.
A few questions:
What strategies helped you land your first data analyst role?
How important are GitHub projects versus certifications?
Are Forage, Kaggle, or volunteer projects valued by recruiters?
Should she focus on healthcare/pharma companies like Pfizer and IQVIA, or apply broadly across industries?
Are there specific companies in India (especially Chennai) that are hiring freshers for data analyst roles?
Any tips for networking or reaching out to professionals on LinkedIn?
Any guidance, success stories, or leads would be greatly appreciated.
Thank you!