u/Tricky_Direction_897

I had a modified natural round of IVF - no stimulation, just a pill to prevent early ovulation and a trigger shot. I got my period about two weeks later on the 1st of August. It is now the 18th of August and it seems that my period is starting again. This has never happened to me before including on the other eight rounds of IVF that I’ve done to date. What’s going on?

I’m 38 with DOR, endo, and adenomyosis.

Hi All,

I’m 38. AFC 1-3, AMH 0.02 - 0.3. FSH all over the place. Moderate adenomyosis, endometriosis/ 18mm endometrioma on left ovary, High NK cells and high Cykotines.

TTC for nearly 3 years. Never seen a positive test. Over 9 cycles / 6 egg retrievals, I’ve collected 10 eggs and made 2 blasts on cycles 6 and 8, 1 Day 5 BC (age 37) and 1 Day 5 3AB (38). Untested.

I’m debating going a few more cycles or moving to transfer. If we move to transfer, should I have a lap to remove the endo and do suppression? A handful of REs have said absolutely not to the lap. My new RE says yes, but only if I manage to collect another 3(!) embryos as mine are untested.

What would you do? Any and all advice would be appreciated! Thank you

Hi All,

I’m 38. AFC 1-3, AMH 0.02 - 0.3. FSH all over the place. Moderate adenomyosis, endometriosis/ 18mm endometrioma on left ovary, High NK cells and high Cykotines.

TTC for nearly 3 years. Never seen a positive test. Over 9 cycles / 6 egg retrievals, I’ve collected 10 eggs and made 2 blasts on cycles 6 and 8, 1 Day 5 BC (age 37) and 1 Day 5 3AB (38). Untested.

I’m debating going a few more cycles or moving to transfer. If we move to transfer, should I have a lap to remove the endo and do suppression? A handful of REs have said absolutely not to the lap. My new RE says yes, but only if I manage to collect another 3(!) embryos as mine are untested.

What would you do? Any and all advice would be appreciated! Thank you

Hi everyone,

I’m 38 with 2 frozen blasts, a Day 5.5 BC (age 37) and a Day 5 3AB (newly 38), both untested. I’m trying to decide if I should do a few more rounds to try for a 3rd or if it’s time to move to transfer, in which case I’d like your advice on whether I should do a lap then supression, or just supression.

Diagnosis:

At 36, I was diagnosed with severe DOR: AMH 0.02, AFC 3, FSH 15. Over the past 2 years, I was also diagnosed with moderate adenomyosis, endometriosis with an 18mm on my left ovary which seems to have stopped working, high Natural Killer cells and high Cytokines. Normal BMI and otherwise healthy. My husband is 43 with chronic health and sperm issues but low DNA fragmentation.

If I were to move to transfer, would you go for a lap and then suppression, or just suppression? Because of my severely depleted reserve I’m nervous about the surgery, but equally nervous without losing my only 2 embryos which took me 8 cycles to make.

Any advice? What would you do?

History:

9 IVF attempts. 10 eggs collected across 6 retrievals, 8 mature, 5 fertilised resulting in 1 Day 2 embryo which failed to implant on fresh transfer & 2 frozen blasts. Across these retrievals, I had 2 rounds with total fertilisation failure and 1 round where my embryos were very slow growing and discarded Day 6. Of the remaining 3 attempts, 2 cycles cancelled for no response, 2 for early ovulation (1/2 times still made it to retrieval to get what hadn’t ovulated).

I have switched to natural cycle recently and have had more success with that than with stims; I have done every protocol on the planet (or so it seems).

Cycle History:

Age 36 at ARGC, Cycle 1 12/25: high dose stims. Nearly ovulated early. 2 follicles, 2 eggs overmature, 0 fertilised. Dual trigger, ICSI. Started melatonin.

Cycle 2 2/26: high dose plus omniotrope, AOA, ICSI. 2 follicles, 2 eggs, 1 mature. 1 Day 2 embryo failed to implant during fresh transfer. 35 hour dual trigger. Diagnosed with high NK cells and Cytokines, had intralipids & prednisone. 35 hour trigger

Cycle 3 4/26: same protocol. 2 follicles. 35 hour trigger. Ovulated early. Changed clinics.

ARIA Cycle 4 5/26: synthetic stims. 2 follicles, 2 eggs, both mature, 0 fertilised. 35 hour dual trigger.
Turned 37.

Recommended Ovarian PRP - 2 rounds at 3rd clinic, FGA. June & July 2026.

Returned to ARIA Cycle 5 8/26: low dose stims with omniotrope, ICSI, AOA PIMSI cancelled for no response. Diagnosed with moderate adenomyosis.

Cycle 6 9/26: Same protocol. 3 follicles. Ovulated early. Retrieved 1 egg. Day 5.5 bc blast frozen. 35 hour trigger. Changed clinics

CRGH Cycle 7 01/26: same protocol. Cancelled for no response. Changed diet from high protein to low protein high glucose. Period pain stopped.

Turned 38 Cycle 8 6/27: natural cycle. 1 follicle, 1 egg. Indomactin once LH rose and 10,000 Zivverfert 35 hour trigger. Day 5 3AB blast frozen.

Cycle 9 07/27 natural cycle. 2 follicles, 2 eggs, both fertilised. As of Day 5, 1 at 5 cells and 1 at 7, unlikely to survive. Diagnosed with endo 18mm on left ovary

Hi everyone,

I’m 38 with 2 frozen blasts, a Day 5.5 BC (age 37) and a Day 5 3AB (newly 38), both untested. I’m trying to decide if I should do a few more rounds to try for a 3rd or if it’s time to move to transfer, in which case I’d like your advice on whether I should do a lap then supression, or just supression.

Diagnosis:

At 36, I was diagnosed with severe DOR: AMH 0.02, AFC 3, FSH 15. Over the past 2 years, I was also diagnosed with moderate adenomyosis, endometriosis with an 18mm on my left ovary which seems to have stopped working, high Natural Killer cells and high Cytokines. Normal BMI and otherwise healthy. My husband is 43 with chronic health and sperm issues but low DNA fragmentation.

If I were to move to transfer, would you go for a lap and then suppression, or just suppression? Because of my severely depleted reserve I’m nervous about the surgery, but equally nervous without losing my only 2 embryos which took me 8 cycles to make.

Any advice? What would you do?

History:

9 IVF attempts. 10 eggs collected across 6 retrievals, 8 mature, 5 fertilised resulting in 1 Day 2 embryo which failed to implant on fresh transfer & 2 frozen blasts. Across these retrievals, I had 2 rounds with total fertilisation failure and 1 round where my embryos were very slow growing and discarded Day 6. Of the remaining 3 attempts, 2 cycles cancelled for no response, 2 for early ovulation (1/2 times still made it to retrieval to get what hadn’t ovulated).

I have switched to natural cycle recently and have had more success with that than with stims; I have done every protocol on the planet (or so it seems).

Cycle History:

Age 36 at ARGC, Cycle 1 12/25: high dose stims. Nearly ovulated early. 2 follicles, 2 eggs overmature, 0 fertilised. Dual trigger, ICSI. Started melatonin.

Cycle 2 2/26: high dose plus omniotrope, AOA, ICSI. 2 follicles, 2 eggs, 1 mature. 1 Day 2 embryo failed to implant during fresh transfer. 35 hour dual trigger. Diagnosed with high NK cells and Cytokines, had intralipids & prednisone. 35 hour trigger

Cycle 3 4/26: same protocol. 2 follicles. 35 hour trigger. Ovulated early. Changed clinics.

ARIA Cycle 4 5/26: synthetic stims. 2 follicles, 2 eggs, both mature, 0 fertilised. 35 hour dual trigger.
Turned 37.

Recommended Ovarian PRP - 2 rounds at 3rd clinic, FGA. June & July 2026.

Returned to ARIA Cycle 5 8/26: low dose stims with omniotrope, ICSI, AOA PIMSI cancelled for no response. Diagnosed with moderate adenomyosis.

Cycle 6 9/26: Same protocol. 3 follicles. Ovulated early. Retrieved 1 egg. Day 5.5 bc blast frozen. 35 hour trigger. Changed clinics

CRGH Cycle 7 01/26: same protocol. Cancelled for no response. Changed diet from high protein to low protein high glucose. Period pain stopped.

Turned 38 Cycle 8 6/27: natural cycle. 1 follicle, 1 egg. Indomactin once LH rose and 10,000 Zivverfert 35 hour trigger. Day 5 3AB blast frozen.

Cycle 9 07/27 natural cycle. 2 follicles, 2 eggs, both fertilised. As of Day 5, 1 at 5 cells and 1 at 7, unlikely to survive. Diagnosed with endo 18mm on left ovary

Hi everyone,

I’m 38 with 2 frozen blasts, a Day 5.5 BC (age 37) and a Day 5 3AB (newly 38), both untested. I’m trying to decide if I should do a few more rounds to try for a 3rd or if it’s time to move to transfer, in which case I’d like your advice on whether I should do a lap then supression, or just supression.

Diagnosis:

At 36, I was diagnosed with severe DOR: AMH 0.02, AFC 3, FSH 15. Over the past 2 years, I was also diagnosed with moderate adenomyosis, endometriosis with an 18mm on my left ovary which seems to have stopped working, high Natural Killer cells and high Cytokines. Normal BMI and otherwise healthy. My husband is 43 with chronic health and sperm issues but low DNA fragmentation.

If I were to move to transfer, would you go for a lap and then suppression, or just suppression? Because of my severely depleted reserve I’m nervous about the surgery, but equally nervous without losing my only 2 embryos which took me 8 cycles to make.

Any advice? What would you do?

History:

9 IVF attempts. 10 eggs collected across 6 retrievals, 8 mature, 5 fertilised resulting in 1 Day 2 embryo which failed to implant on fresh transfer & 2 frozen blasts. Across these retrievals, I had 2 rounds with total fertilisation failure and 1 round where my embryos were very slow growing and discarded Day 6. Of the remaining 3 attempts, 2 cycles cancelled for no response, 2 for early ovulation (1/2 times still made it to retrieval to get what hadn’t ovulated).

I have switched to natural cycle recently and have had more success with that than with stims; I have done every protocol on the planet (or so it seems).

Cycle History:

Age 36 at ARGC, Cycle 1 12/25: high dose stims. Nearly ovulated early. 2 follicles, 2 eggs overmature, 0 fertilised. Dual trigger, ICSI. Started melatonin.

Cycle 2 2/26: high dose plus omniotrope, AOA, ICSI. 2 follicles, 2 eggs, 1 mature. 1 Day 2 embryo failed to implant during fresh transfer. 35 hour dual trigger. Diagnosed with high NK cells and Cytokines, had intralipids & prednisone. 35 hour trigger

Cycle 3 4/26: same protocol. 2 follicles. 35 hour trigger. Ovulated early. Changed clinics.

ARIA Cycle 4 5/26: synthetic stims. 2 follicles, 2 eggs, both mature, 0 fertilised. 35 hour dual trigger.
Turned 37.

Recommended Ovarian PRP - 2 rounds at 3rd clinic, FGA. June & July 2026.

Returned to ARIA Cycle 5 8/26: low dose stims with omniotrope, ICSI, AOA PIMSI cancelled for no response. Diagnosed with moderate adenomyosis.

Cycle 6 9/26: Same protocol. 3 follicles. Ovulated early. Retrieved 1 egg. Day 5.5 bc blast frozen. 35 hour trigger. Changed clinics

CRGH Cycle 7 01/26: same protocol. Cancelled for no response. Changed diet from high protein to low protein high glucose. Period pain stopped.

Turned 38 Cycle 8 6/27: natural cycle. 1 follicle, 1 egg. Indomactin once LH rose and 10,000 Zivverfert 35 hour trigger. Day 5 3AB blast frozen.

Cycle 9 07/27 natural cycle. 2 follicles, 2 eggs, both fertilised. As of Day 5, 1 at 5 cells and 1 at 7, unlikely to survive. Diagnosed with endo 18mm on left ovary

Hi everyone,

I’m 38 with 2 frozen blasts, a Day 5.5 BC (age 37) and a Day 5 3AB (newly 38), both untested. I’m trying to decide if I should do a few more rounds to try for a 3rd or if it’s time to move to transfer, in which case I’d like your advice on whether I should do a lap then supression, or just supression.

Diagnosis:

At 36, I was diagnosed with severe DOR: AMH 0.02, AFC 3, FSH 15. Over the past 2 years, I was also diagnosed with moderate adenomyosis, endometriosis with an 18mm on my left ovary which seems to have stopped working, high Natural Killer cells and high Cytokines. Normal BMI and otherwise healthy. My husband is 43 with chronic health and sperm issues but low DNA fragmentation.

If I were to move to transfer, would you go for a lap and then suppression, or just suppression? Because of my severely depleted reserve I’m nervous about the surgery, but equally nervous about losing my 2 embryos which took me 8 cycles to make.

Any advice? What would you do?

History:

9 IVF attempts. 10 eggs collected across 6 retrievals, 8 mature, 5 fertilised resulting in 1 Day 2 embryo which failed to implant on fresh transfer & 2 frozen blasts. Across these retrievals, I had 2 rounds with total fertilisation failure and 1 round where my embryos were very slow growing and discarded Day 6. Of the remaining 3 attempts, 2 cycles cancelled for no response, 2 for early ovulation (1/2 times still made it to retrieval to get what hadn’t ovulated).

I have switched to natural cycle recently and have had more success with that than with stims; I have done every protocol on the planet (or so it seems).

Cycle History:

Age 36 at ARGC, Cycle 1 12/25: high dose stims. Nearly ovulated early. 2 follicles, 2 eggs overmature, 0 fertilised. Dual trigger, ICSI. Started melatonin.

Cycle 2 2/26: high dose plus omniotrope, AOA, ICSI. 2 follicles, 2 eggs, 1 mature. 1 Day 2 embryo failed to implant during fresh transfer. 35 hour dual trigger. Diagnosed with high NK cells and Cytokines, had intralipids & prednisone. 35 hour trigger

Cycle 3 4/26: same protocol. 2 follicles. 35 hour trigger. Ovulated early. Changed clinics.

ARIA Cycle 4 5/26: synthetic stims. 2 follicles, 2 eggs, both mature, 0 fertilised. 35 hour dual trigger.
Turned 37.

Recommended Ovarian PRP - 2 rounds at 3rd clinic, FGA. June & July 2026.

Returned to ARIA Cycle 5 8/26: low dose stims with omniotrope, ICSI, AOA PIMSI cancelled for no response. Diagnosed with moderate adenomyosis.

Cycle 6 9/26: Same protocol. 3 follicles. Ovulated early. Retrieved 1 egg. Day 5.5 bc blast frozen. 35 hour trigger. Changed clinics

CRGH Cycle 7 01/26: same protocol. Cancelled for no response. Changed diet from high protein to low protein high glucose. Period pain stopped.

Turned 38 Cycle 8 6/27: natural cycle. 1 follicle, 1 egg. Indomactin once LH rose and 10,000 Zivverfert 35 hour trigger. Day 5 3AB blast frozen.

Cycle 9 07/27 natural cycle. 2 follicles, 2 eggs, both fertilised. As of Day 5, 1 at 5 cells and 1 at 7, unlikely to survive. Diagnosed with endo 18mm on left ovary.