Ebselen for Hyperacusis

Hey all

I'd like to make it short. I have had moderate hyperacusis for years. Now that would be manageable if I didn't get a permanent worsening of my tinnitus each time I have a setback. I have encountered periods of instability where my hyperacusis went down to severe and I accumulated loads of worsenings. Fortunately I managed to stabilize again (usually with loads of silence and some luck). I seem currently at the start of another such period, and my tinnitus and situation have become so hard to endure at this point that I am willing to start experimenting with whatever medicine I can get hold off. I don't have a choice anymore.

I am wondering if anyone has tried Ebselen already (by importing it from China). So far I've seen one report from u/Dents1993, who said he didn't see an improvement. I wonder if anyone else has personal experience with Ebselen that he or she could share?

Big thanks in advance for any information you can provide.

reddit.com
u/WiseMorning1 — 6 days ago

Progressively worsening tinnitus

Hey everyone.

I just wanted to try my luck because maybe somebody has some knowledge that might be helpful. I've had tinnitus and hyperacusis since a somewhat loud concert in 2019. I rigorously tried to protect myself in the following years, but you can't always predict what is going to happen and over the years I was exposed to the occasional loud noise that worsened both conditions. My tinnitus interacts with my hyperacusis in a way that if my loudness discomfort level from hyperacusis is crossed significantly, I always without fail get a permanent spike about 10 hours later. It never gets better, and the increase in volume of my tinnitus is also always the same.

I've had long periods of stability over the years where things just stayed the same, then the isolation would make me somewhat depressed eventually and that would make me kinda out of nowhere super sensitive to noise, where even very low sounds could give me a permanent spike. I had another period of stability for the past four months, now it seems that I might slip into a period of instability again. The tinnitus is loud and I'm just starting to feeling kinda done, since it just never gets better. So far I've always gotten used to the spikes, I mean it's always kinda the same experience with very predictable increases, but the volume is starting to make me feel depressed.

I've obviously become a hermit years ago, last year I was still able to leave the house for very specific types of walks out in nature (I live in a rural area), now not even that is possible. I guess if it continues I'll just hit the next bout of depression that will erode my stability again, and then it might be game over this time.

I'm not sure what's wrong with me that I always get permanent spikes. I'm wondering if anyone here has been in the same situation, and has found a way to make these damn spikes temporary.

reddit.com
u/WiseMorning1 — 7 days ago

Scrolling suddenly has insane lag in browsers only

I'm being confronted today with a bizarre new behaviour of my Logitech Mouse (a M510). When I try to scroll down in browers (same behaviour in both Firefox and Chrome), I experience intense lag and the scroll happens very choppedly over a duration of 30-60 seconds, basically making it unusable. Curiously in any other program (Word, Excel, Discord), it works perfectly normal. Using arrow keys or page up/page down to navigate browers works normal too, as does scrolling down while pressing the scrolling wheel. Just the normal wheel scroll without pressing it down doesn't work anymore. Restarting computer did nothing.

Does anyone have an idea what happened here? Thank you very much in advance for any help.

Edit: I've tried installing some other browsers. The problem persisted in Google Chrome, but not in Brave or DuckDuckGo Browser. Very unusual.

reddit.com
u/WiseMorning1 — 9 days ago

Is dry mouth always a problem?

I (35m) tend to have somewhat dry mouth at night (not using any meds and not smoking). I've been wondering to what extent this is a problem. From my current understanding, cavities form due to enamel being eroded by acid, either by consuming acidic foods/beverages directly or from carbs that get fermented by bacteria in your mouth. Saliva acts as the natural defense mechanism since it's slightly alcalic and thus neutralizes acids, and also remineralizes teeth.

Now let's say I'd stop eating carbs in the evening and do a really great job with cleaning my teeth before sleeping. So there's kinda nothing to attack my teeth even if I have low saliva during the night. Is this a correct take?

reddit.com
u/WiseMorning1 — 29 days ago
▲ 0 r/keto

How much carbs is in a roux?

I've been a bit unsure about this. Certainly the flour in a roux before cooking is full carbs, but the Maillard reaction leads to the formation of melanoidins which are polymers. Are these polymers still carbs? And how much flour is transformed into melanoidins?

reddit.com
u/WiseMorning1 — 3 months ago

Can you prevent cavities just by rinsing with water?

So I learned that cavities are essentially just a balance problem where too much acid is in your mouth, either due to sour food or carbs that get metabolized by bacteria into lactic acid, and your saliva and fluoride can't keep up to reverse the resulting demineralization of your teeth. From what I believe to have read is that demineralization happens mostly within 30-60mins after eating carbs and that most carbs has been metabolized already by then (or is that just simple sugars?). If that is the case, if I repeatedly rinse my mouth with water within those 30-60mins, wouldn't I constantly neutralize those acids in my mouth and thus prevent a demineralization and as such the potential for cavities?

Another thing that interests me, wouldn't food stuck in your mouth give bacteria food for longer than those 30-60mins?

reddit.com
u/WiseMorning1 — 3 months ago

Possible buccal pit cavity / managing a cavity without drilling

Thank you very much for this subbredit in advance. This is going to be a bit of text, I've added a TLDR at the end.

Going to the dentist has been complicated for the past years as I've started suffering from worsening hyperacusis (sound hypersensitivity). The neurological condition has been bad enough that I have major trouble leaving the house, even with hearing protection. Dentist cleanings have been done purely manual and without suction device for the past few years because anything more risks making the condition permanently worse. So obviously the prospect of drilling isn't a quick little procedure but more like a potential death sentence as the worsening would likely be absolutely massive.

I've been taking care of my teeth because I was aware of the risks of drilling. I'm in my mid thirties, I don't drink at all, drink soft drinks maybe once a month and eat very little sugar (and for the past year have cleaned my teeth immediately after). Sadly it didn't seem to work out as I hoped because recently I've noticed two small dark spots on the buccal pits of my wisdom teeth. I estimate my tooth brush didn't reach that area with sufficient efficiency and I tend to have dry mouth. It's a rather hidden spot and my camera doesn't have great resolution, so I can only post an approximate foto of another user.

https://www.reddit.com/r/askdentists/comments/plmbmo/noticed_a_small_black_dot_at_one_of_my_teeth_i_do/

Looks about like the case of this user (but on the wisdom teeth), the dark area is slightly bigger in my case (estimate 1,2mm in diameter). Perceived depth feels in a grey area where it could be a somewhat deep buccal pit with stain or a smaller one with initial carious activity.

Obviously my dentist will be able to tell more with probing and an X-ray. He's unfortunately not the most communicative person, I've tried asking him via e-mail about my options and haven't received an answer at all. I've had a strong impression in the past that he sees my neurological condition just as an exaggerated fear of sound (which it definitely isn't). I will have an appointment in two weeks and I somewhat fear he will just tell me to get the cavity filled and tough it out, in case it is a cavity of course.

So I've been researching my options myself since I absolutely can't have drilling in the near future. From what I've seen if the enamel hasn't been breached I'm good and can use stuff like high-fluoride tooth-paste, and even for non-cavitated dentin caries there seem to be options like Curodont Repair. It seems though that once the cavity has grown past this stage my options are limited to arresting the cavity with Silver Diamine Fluoride, which spares me the drilling but would need reaplication every 6 months and stain the affected part permanently dark (which is irrelevant, since it's a visibly hidden spot). Filling with laser isn't an option since it seems you still need to mold/polish the filling at the end, which requires a drill-type tool.

TLDR: So my question at the end is: Do I have the right understanding that dentin caries can be arrested reliably with Silver Diamine Fluoride, as long as you keep reapplying it and improve your oral hygiene?

reddit.com
u/WiseMorning1 — 3 months ago