u/chaoserrant

Does anybody have low back weakness/instability from repatha? Like hip instability or weakness around SI joints? I had the classical back pain episodes for 1-2 days after the first 2 doses and then the pain went away later on but my low back is weaker and weaker. Or rather unstable....as if i have time recruiting the stabilizing muscles in the core....the problem is I have other competing causes that could explain this but the timing makes me wonder....

Does anybody have a low back symptom that is not pain?

Below is the list of symptoms that am more and more convinced is postviral related (though not officially diagnosed with anything). If you had something similar what did it help if anything?

1. Joint laxity. Not at the level of EDS but as an active person I notice certain joints that are subject to sudden movements or more stress they stretch too much. They feel as if they dislocate a little. Examples: toes (I walk and hike 5 miles a day on average), neck (on occasions it feels it twistes too much), hips (feels stuck on one side or another)
2. Tendons. This is my biggest issue and I torn already the big toe tendon last year from running before I realized the problem. Tendons again feel far too vulnerable under regular load. Aside from feet I had big issues with elbow tendons. they burn and feel ready to give out from regular things such as lifting a bottle or pulling a tight door etc...
3. Fascicluations in random places. (though this may be anxiety related due to als scare)

These symptoms have some pattern in the last 2 years. Periods of worsening alternating with improvement. One episode really bad last year then steady improvement (I even began to lift again at the gym) and then another relapse starting a week ago. Not as bad as last year but seems to worsen

I had an ALS scare but repeated neurological examinations and emgs found nothing but mild radiculopathy which I suspect is secondary to these joint problems. Basic rheumatology panels negative.

I threw the chicken sink of supplements I figured may help: B1, B2, B12, L-Acetyl-Carntiine, Lactoferrin, Inositol, Lysine, Augmented NAC, vit D, Magnesium, vit K2, creatine (10grams a day), iron (because I have low ferritin with no explanation)

One interesting thing is normally creatine has a great effect on me. I feel the muscles pumped out and helps me in the gym, helps with walking stability etc....But, crucially, when I have these symptoms relapse it seems the creatine has little to no effect. Not only I feel the tendons strained but the muscles suddenly lose some volume as if I am dehyrdated though I drink plenty

I am looking to see if I have spike protein persistence (there is a lab in Germany that tests this). the only lab I have that somewhat relates to this is the antibody count which is very high in my case (over 20,000 u/ml) but some doctors say it does not automatically indicate the virus or viral particle are present

The patterns in the last months are so strange and hard to believe i worry doctors will think i am insane if i tell them.

First of all until a week ago i had a nearly 2 months of continuous improvements in problematic areas such as the right hand and feet. My strength program supported by creatine was going fine. Managed to lift 20 lbs with arms.

In a week i have to travel to Europe for 2 months to see my mother. It is stresful and anxiety ridden period for mamy reasons. Starting a werk ago almost overnight muscles feel more and more drained. Creatine seems to have little to no effect. Joints feel loose and the ones used more feel stretched. Particularly elbows or toes. Fasciculations increased a little.

I wonder if stress related what possible hormone could cause such an effect but it feels hard to believe.

I still wonder about strange post viral things. 3 days ago i was teaching in the clasroom and i had this allergy attack out of the blue. Felt all of a sudden pins and needles in the back of the nose and eyes, runny nose suddenly. I had to stop couple of times and students probably thought i was on drugs. It went away in 5 minutes but have no idea why it happened.

I plan to use one of these independent labs in Germany to test for spike protein. Might be a waste of money but i wished i get some confindence of the source of the problem at least.

Timing and patterns seem to point to some severe effect from stress or something autoimmune. I thought i would share this because maybe others notice similar patterns

Unfortunately i have lots of comorbidities which makes it hard to figure out the cause but have to ask did anybody experience core weakness rather than pain from repatha.

With first 2 doses i got the classical side effects of low back pain for 2 days post dose. The pain went away and it did not re-appear with later doses but i have the impression thst since that time my core is much weaker. Slouches so to speak and i dont feel the muscles there well. Now i have an old mild disc problem and othet suspected issues but i wonder if anyone can relate with low back symptoms that are not pain

I noticed something that I think justifies checking ApoB and maybe even using it instead of LDL as a treatment goal. What I noticed on Repatha plus Zetia (my current regiment) is that the difference between LDL and ApoB is greater in the sense that I get better (lower) ApoB levels for similar LDL values. I track both cause now you can get these cheaply if paid cash. On 20 mg Crestor and Zetia LDL was 88 and APoB 84, with 10mg Crestor plus Zetia LDL was 104 and APoB was 94. Now on Repatha plus Zetia LDL is 107 and ApoB is 86. LDL is a calculated value anyway... Still not ideal values but my cardiologist agreed with me that I can focus more on ApoB as target goal if I want to.

I wonder if it is just individual variation or is there something about PCsK9 inhibitors that have a better effect on lowering ApoB than statins