switching SSRIs?

what's up gamers, hope you're doing okay. I'm trialing a microdose of tirzepatide for PGAD and I'm not sure yet if it's helping. I'll continue to monitor.

I also currently take 25mg Zoloft. I've been on a few different SSRIs in my life, and my PCP suggested maybe switching to Lexapro or a different one to see if the sexual side effects get any better. I'm willing to try, but I'm honestly a bit terrified. my nervous system doesn't function on its own really at all. super cool and fun.

I absolutely cannot take SNRIs - duloxetine sent me to the ER 3 times. I lost 30 lbs in 2 months. was vomiting constantly. my body hates any increased norepinephrine.

has anyone had success with their PGAD symptoms by switching antidepressants? thanks much!

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u/doinmydarndest — 7 days ago

hormones & endo/adeno

hi everyone, I'm 26F, been in PFPT for about a year.

I think that my pelvic floor issues are mostly due to (diagnosed) endometriosis/adenomyosis and hormone fluctuations. I've had great success with reduction of pain on norethindrone (Aygestin) 5mg daily, but there are so many side effects.

my most unbearable side effect of synthetic hormones is increased inflammation and blood flow in my vulva, which plays a big role in my issues with PGAD (persistent genital arousal disorder). it's either I have pelvic floor muscle pain (soreness, burning, zaps, stabbing sensations) OR I have PGAD. I haven't found an in-between.

I'm strongly considering trying bioidentical progesterone instead of other synthetic progestins. apparently it has fewer side effects and has anti-inflammatory properties.

this is probably a very niche question for this sub, but I'm wondering if there are others who can tell me their experiences with bioidentical progesterone and the effect it has on their pelvic floor (if any). thanks very much!

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u/doinmydarndest — 1 month ago

hi friends! I'm 26, no kids.

I'll be getting the Mirena (or a different hormonal IUD depending on my uterus size) placed in about a month, and I'm willing to give it a try despite all the horror stories. I've tried so many other things that haven't worked, so, why not?

the thing is, I don't have the super heavy bleeding symptom of adeno. I've been diagnosed with adeno on MRI and ultrasound. no fibroids. I bleed a pretty normal amount, BUT I constantly feel like I'm carrying a bowling ball around in my pelvis and am always in pain. it feels like something is sitting on my bladder all day. I deal with a lot of inflammation and nerve pain too.

I tend to gaslight myself about adeno because I lack the bleeding symptom. but I've gone through so many other tests to figure out my pelvic pain, and it seems that adeno is the only logical explanation. a hysterectomy is on the table if the IUD doesn't help. but surgery is a last resort for me.

wondering if I'm not alone in this? are there others with adeno who DON'T have the heavy bleeding? has the IUD helped with pelvic pressure and pain for you?

I'd rather not read more negative stories about IUDs in the comments of this post, since I already know it's very hit or miss. I'll never know how my body will react until I try it.

thanks very much!

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u/doinmydarndest — 2 months ago

any at all would be nice :) maybe symptoms have improved for you. maybe you're in remission entirely. maybe you met a cute dog today. maybe your friend landed her dream job. just looking for hope 💜

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u/doinmydarndest — 2 months ago