4 Days on Modafinil 50 mg - Stomach Issues
Title: 4 days on Modafinil (50mg). Incredible mood improvement, but now stomach issues. Anyone else?
I started taking modafinil Monday Oct 5th for excessive daytime sleepiness. My doctor prescribed 100mg but agreed I could start with 50mg to see how I tolerate it. ( I don’t take meds outside of my thyroid med )
For some background, I have mild sleep apnea and struggle with pretty severe daytime fatigue. Around 1-5pm, I can become completely exhausted. It affects my mood, patience, motivation, and ability to concentrate.
Day 1 was honestly incredible. I felt almost wired, but in a good way. My appetite practically disappeared, my energy was great, and my mood improved dramatically.
But the biggest surprise wasn’t the energy. It was my personality.
I’m normally very irritable, especially when I’m exhausted. Little things bother me, and sometimes I don’t even have the patience to explain something because it feels like too much effort.
On modafinil, I’d say I’m literally 70-80% nicer. I’m happier, calmer, more patient with my wife, more social, and even enjoy striking up conversations with strangers. My anxiety and negative feelings seem significantly reduced.
It’s honestly been amazing to experience this version of myself.
Now the downside.
I’m on day four, and the initial intensity has gradually decreased. I’m also developing mild but persistent stomach cramps, some digestive discomfort, and extremely dry mouth. My appetite has also started returning.
I’m currently traveling and forgot my sleep apnea mouthpiece, so I realize poor sleep and other factors might be affecting how I feel.
I also notice some of my usual irritability returning around 8–9pm.
I’m concerned about the stomach issues because I already have a history of gastritis. I really don’t want to give up something that’s helped me this much, but I also don’t want to create another health problem.
A few questions for anyone who’s been on modafinil longer:
Did anyone experience this kind of dramatic improvement in mood, patience, or anxiety?
Did stomach cramps or digestive issues eventually disappear, or did they get worse?
Did the positive mood effects last, or was it just an initial honeymoon period?
Does anyone take it only as needed rather than daily?
If you stopped taking it, did your mood simply return to baseline, or did you temporarily feel worse?
I’m speaking with my doctor about all of this, but I’d really appreciate hearing people’s personal experiences.
I genuinely feel like I’ve gotten a glimpse of what life could be like without constant exhaustion and irritability. I just hope there’s a way to maintain those benefits without the stomach problems.