u/somethingicanspell

Medicine could be revolutionized if

1. All patients were genetically sequenced
2. All medical outcomes were tracked in tandem with patient's genes with millions of observations
3. Privacy Regulations were weakened to allow for this mass tracking of outcomes and the training of machine learning algorithms to generate novel insights at lower and lower costs
4. Clinical Practice was restructured to take into account the ever increasing amount of information about how genetics affected the odds of a diagnosis and likely treatment response and this became a standard tool in personalizing and guiding treatment

This would not happen overnight if everyone's genes were sequenced but it would provide the necessary backbone to revolutionize medicine as more and more data was generated and clinicians were trained or retrained to incorporate these insights into how they practice. We could imagine that the ideal anti-depressant for a patient could be selected after treatment response was compared to the genetics of the many millions of patients on each type of anti-depressant.

The advantages of improved health outcomes for patients would outweigh the privacy concerns stemming from the generation of a such a dataset. The world is already transparent the use of grades, BMI, credit card spending and existing medical information, and online activity would be sufficient already to build an Orwellian surveillance state if anyone really wanted to. Genetic data is not going to change the picture much and fears are overblown

Implementing this system would require a lot of work and stepping on the toes of patients, providers, and health insurance companies who would all have their own reasons for not wanting to embrace it but it is no longer impractical to do with significant investment and regulatory easing from the government.
When adjusting for labor costs, the cost of sequencing a whole genome at high fidelity is about $500 (the raw cost is closer to $200 and a cheaper targeted genetic screen could be implemented for much less), and this only needs to be performed once. Likely, this cost would go down by a factor of two after some upfront investment in the government and the gradual improvement of sequencing machinery. In contrast a Colonoscopy costs about $1000 and will be performed ~3-5 times per lifetime. The cost of generating high quality raw genetic data is not a limiting factor in medicine, the lack of interest, expertise or infrastructure to interpret the data into clinical decisions is and this a problem that could be overcome.

A new analysis of DESI DR1 Full-Shape + DESI DR2 BAO comes close to restoring concordance with Lambda CDM.

Very intriguing theory that provides a physical explanation for dark energy that seems plausible and requires few assumption. My understanding is the framework could explain the Hubble tension and DESI anomaly although looking at the math thats still a bit far way in my opinion but it does offer a mechanism to do so. That said a bit outside what I know well can any cosmologist share their thoughts on how plausible this is?

The biggest thing that makes me doubt my faith is I find hell impossible to reconcile with Christ.

I guess I’m a coward and I don’t want to burn in hell, but if anyone I deeply cared about was in hell I feel like a coward if I was saved and I let them burn. It’s like an officer who flees on horseback and lets his doomed enlisted men he’s responsible for die in a last stand without having the courage to die with them. How would I be able to enjoy salvation knowing others are left to a horrific fate doing so seems obscene and selfish. Christ suffered enormously to carry our sins there doesn’t seem anything more Christ like than suffering with your brothers. I admit to being too selfish to feel the same way for strangers as for those I deeply care about but I imagine that Christ loves all of us more than I love anyone and I just can’t imagine wanting anyone to burn in hell and be ok with that

For the purposes of this question I'm largely interested in physicists or grad students answers. I have a good grasp on the experimental program in particle physics, cosmology and astrophysics.

I also understand that the basic idea of unification with some sort of Lie algebra group that arguably has driven a lot of BSM physics since the 1970s is beginning to run into serious constraints

I'm not particularly well informed on what the major theory projects are and what the trend in the theory community is. Is much of the work still focused on unification or is the field dominated by new ideas and if so what?

It’s easy to fall through the cracks of the medical system as often times chronically ill patients are given low prioritization for care this can disguise serious problems and delay recovery as many know.

In general, if you have PCP who is prioritizing your care it’s good to address things via appointment where possible as it’s generally preferred but when you are falling through the cracks patient portal messages are good ways to protect your access to healthcare

Why?

1. You are creating a formal paper trail of your symptoms and response to interventions that in the event of misdiagnosis/neglect will make it much easier to receive financial compensation
2. It make it harder to dismiss your illness on grounds your not making the necessary lifestyle changes sending a status report of what you tried what’s working and what’s not once a month and what questions you have clearly outlines if an intervention is working and is more likely to lead to changes
3. Doctors generally do not want to address mychart messages but are still responsible for taking into account what you say from a liability standpoint making it more likely to get an appointment. If doctors cannot make a timely appointment to address an issue that now becomes more clear in the written record

There’s no point of getting angry in a mychart message as that can muddy the facts. Dispassionately as possible outline what you have done, what is changing, what is still bothering you, and a simple open ended question of how do you wish to proceed. Sending an update once a month or once every two months is more likely to be effective barring serious emergent issues than very frequently as that is more likely to be ignored

I understand my critique is open for theological debate given that the Bible does not directly comment on it but I am firmly against AI and see it as a spiritual crisis of our time 

All men and women are made in gods image. Every man no matter how despicable cannot help but feel the Holy Spirit’s pull. Paul of Tarsus was a venal persecutor of Christians but on the Road to Damascus the Lord revealed himself to Paul and he could not resist Gods grace, goodness, and mercy. Many sinners speak of similar tales. Creation is ultimately benevolent even if fallen because God constantly guides us to Christ and a better world

AI has no soul, it has no mercy, it has no relationship with Christ. The builders of AI aim to create a superior man, one who is smarter, who doesn’t tire, who doesn’t question its orders,  a man free from the limitations and gifts that god bestowed to our human soul. I firmly believe this an abomination and modern Tower of Babel. Imagine wars conducted by autonomous drones without soul, with no innate desire to seek Christ and have no Christ striving mercy for their fellow man. Imagine a super intelligent state police agent capable of detecting the subtlest patterns of dissent and creating the perfect message to manipulate its citizens. Imagine AI girlfriends designed to indulge every pleasure and psychiatric weakness of their partner devoid of any of the love or sacred bonds God intended for man and woman. 

If AI aims to create a world in which man is dependent on soul-less automatons to do all of its labor so we can indulge a life of idleness I am highly skeptical of the spiritual value of a life of leisure and dependency.  If AI aims to strip workers of their livelihoods and the dignity of their flawed but god inspired labor then it’s a disgusting abomination that as a brother to all men I condemn. I see no value in a world of soul-less autonomous agents nor do I believe man can improve gods creation by creating a soulless mimic of gods inspired creation of a human soul and human intelligence. 

I am deeply troubled by this and would like to hear your thoughts and spiritual guidance

I know all sky surveys have been done in various wavelengths and I know at larger distances very large planets could exist that evade detection. My question is within 100 AU what would be the largest object that could have evaded detection until now?