r/Tirzeglutide

Has anybody been on both Reta and Tirz who can share some insight on which they liked better and which had less side effects? Thank you so much.

I was using AltRx for my tirz, started back in Aug 26 and when I was due for my net month they took forever. Example: paid my month on Sept 15,26, script sent to pharmacy on Sept 22 and I just received my medication today (10/06/26). Crazy!!

So I took the initiative and switched to Rift and chose the 3mo plan. Best decision ever. I received my meds and they have a BUD of 12/15/26.

Now I need you guidance and assistance what should I do with the tirz from AltRx, they have a BUD of 12/27/26.

I don’t want to waste this golden liquid, it hurts me.

I took 2.2mg of this compounded Tirz and the next day i felt horrible. I had muscle aches (flu like) back pain and badly flushed face. The muscle aches got better, but the flushing got worst and spread to my shoulders and arms and itching in my legs. Felt bad through out the day, like weak and fatigued. I have not taken my next shot, I am afraid. the side effects.

Anyone else experience this?

*** new to this*** i got a 60mg bottle of triz and am seeing that one bottle should not go past 2 months but with my plan I’ll be using the same bottle for about 3 months. Should i split the amount in another sterile bottle and freeze it? I’m adding 3 Ml of bac h20. also in total I purchased 5 of the 60mg bottles will the rest be fine for a long time as long as they’re not opened or punctured? * my husband is planning to eventually start too*

Can anyone help how much bac water to add to a 60mg vial I’m on high doses 12.5mg

hi I took my very first shot on triz at 2.5mg today and idk if I’m trippin but I got super tired like a couple hours after taking the shot and now I’m having kind of like mild body aches and it’s been like 8 hours since, it feels like a bit like the flu or something. is this normal? has anyone experienced this, I’m getting kind of anxious. my eyes started twitching too randomly

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I (60F) lost 90lbs with 5mg tirz weekly over about 15 months, and have kept it off for over a year. Overall I feel better than ever and my inflammation is way down, making it so much easier to be active.

Over the summer I suddenly started snacking a bit more, and I wanted a little something before bed, and I could now finish a big restaurant meal instead of splitting half of it to-go. And just little changes here & there, causing me to gain 10lbs. I attributed it to stress, poor self control, maybe the 5mg just wasn't cutting it anymore?? And though I'm still ok and haven't yet gone up a pant size, I felt like this was a really scary trend and dreaded what it might mean.

I have familial high cholesterol. If I don't take statins my total cholesterol is around 350. I've taken a statin since my late teens (over 40 years), with an 8 year break when I had my kids and was nursing.

I recently started seeing a cardiologist for preventive care. All good - the statins have done their job over the years and I don't have heart disease. I was on 40mg atorvastatin and 10mg Zetia and he raised the statin to 80mg in June because of my family history (brother didn't take statins and had a quad bypass at 56) and the new guidelines for even lower total cholesterol and LDL. He also started me on Repatha, the new cholesterol lowering drug (not a statin) that helps lower LDL dramatically.

Then I saw a YT video by a geneticist who said in passing that statins, particularly high-dose statins, lower GLP-1 in the body. I was like WHAT?! Replayed it a couple times to make sure I heard that right, and then went down a rabbit hole. Yes, in fact, statins DO lower GLP-1 and other satiety hormones in our system, and now I'm mad/sad that I blamed myself for the 10lbs. and relieved that I have an answer and I'm not doomed to gaining back all that weight. And I'm not surprised at all that a drug I've been on my whole life is JUST now being shown to cause weight gain, and that my lifestyle and lack of self control was blamed instead by every medical professional and casual bystander I ever came across. No, not bitter at all....

I'm hoping that the Repatha lowers my LDL enough to go back down to 40 on my atorvastatin and it'll become easier again to keep the weight off. Meanwhile, I'm going up on my tirz. Went up to 7mg, and I'll just go up to 10mg or more if necessary, while I'm still on 80mg statins.

Here's some of the research, for others who are also on statins. I'm a HUGE proponent of statin therapy with proof that they work, and am not recommending anyone go off statins. I still have my mom with me, as healthy as ever at 83, because of statins. I also realize that some people have side effects from them that are too much to continue them. And I'm so glad this new drug Repatha, which isn't a statin, is now available for those of us with familial high cholesterol.

Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner: https://www.sciencedirect.com/science/article/pii/S1550413123005053

Statins decrease leptin expression in human white adipocytes: https://pmc.ncbi.nlm.nih.gov/articles/PMC5789723/

Can Taking Statins Make You Gain Weight?: https://www.goodrx.com/classes/statins/statins-weight-gain

I’ve been on tirz the last 6 months but will researching Reta now because honestly the blindness lawsuit freaked me out so I’m gonna give Reta a shot. Any advice or what was your experience making this transition ?

*UPDATE: I’ve decided to stay on Tirz, didn’t want to risk weight gain and have received more insight on what caused blindness and I don’t believe I have a high chance of it affecting me.

When I started Reta it was a dream, great appetite suppression and I did not crave anything unhealthy and I dropped weight and gained muscle. At 2mg I now woke up super hungry one day and have been super hungry ever since.

I have a trip in December so I want to cut a bit for it, I'm thinking of adding tirz. How low should I start, should I take both on the same day?

Anyone who has done this and can tell me their experience?

TIA

So I have been on tirz since June 6th. I am currently taking 5mg every Friday night. I upped my mg from 3.5 to 5 back on August 14th. I was curious if anyone would recommend adding Reta and if so what I should do for both dosages? I feel like the last few weeks my weight hasn’t moved at all. And my food suppression isn’t the best. Maybe I’m just impatient and need to wait it out. Just looking for suggestions and advice. Thanks in advance!

Stalled, switching over to Reta what's a good way to proceed? What dose should I start the Reta at?

Hello guys,

Tirzepatide cost too much in europe where i live and i got retratrutide.

i'am ending my 7,5 mg tirzepatide .. so i wanted to know how to switch to reta and what dosage?

How was your swap? and did you had more benefits using Retatrutide ?

Thank you in advace