r/cbdinfo

How does the cbd weed work?

I have an active medical cannabis prescription however I’m pregnant and can’t smoke it but I’m really struggling with my anxiety and honestly not been able to feel relaxed. I was looking at cbd weed so I can still have a smoke if I need to but was really concerned that I would be buying “cbd” but not actually and it being thc with I can’t have. So I just wondered how it makes you feel. I’m aware I won’t actually feel that high that I do from THC weed but I was looking for something to make me relaxed

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u/WiseAstrologer — 17 hours ago

Looking for a CBN/CBG website

I recently got some free samples for cbn & Cbg, I’m looking to get a full sized product, but they’re all super expensive. Does anybody know of a site that has CBN/CBG products that are good quality, but not overpriced? I just want CBN on its own & CBG on its own, I don’t mind if it’s bud/oil/pen/dab. Thank you!

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u/Beautiful-State1046 — 4 days ago
▲ 13 r/cbdinfo+2 crossposts

Nobiletin and limonene synergistically activate OX1R

Cancer cachexia, often observed in patients with advanced-stage cancer, is characterized by the loss of body weight and appetite. The Japanese herbal medicine Ninjinyoeito (NYT), which is composed of 12 crude herbal components, has been used as a therapeutic in Japan to improve anorexia and fatigue, which are commonly observed in cancer patients with cachexia. We have previously reported that Citrus unshiu peel (CUP) contained in NYT can enhance food intake by activating the orexin 1 receptor (OX1R). Using the CellKey™ system, which offers detection of OXR activity in intracellular impedance changes, NYT and CUP were found to activate OX1R, which in turn was inhibited by SB-674042, a selective OX1R antagonist. Among the flavonoids contained in CUP, nobiletin and hesperidin, but not naringin, activated OX1R. Furthermore, some monoterpenes contained in CUP, including limonene and linalool, but not terpineol, activated OX1R. In addition, nobiletin and limonene synergistically activated OX1R when added simultaneously. However, neither NYT nor CUP induced OX2R activity. The results collectively suggested that the CUP contained in NYT activates OX1R, but not OX2R, and that flavonoids and monoterpenes in CUP can synergistically activate OX1R. These findings could provide evidence supporting the therapeutic potential of NYT in cancer patients with cachexia.

https://www.mdpi.com/2218-273X/15/4/533

Tldr:

Nobiletin, Hesperidin and monoterpenes limonene and linalool activated OX1R.

This might explain some of the unknown mechanism of Action for Nobiletin and also Cannabis containing limonene and linalool.

u/Flitzer09 — 5 days ago

Does cbd numb emotions?

I have been using thc alot for emotional regulation, it helped me come down and feel things i was actively pushing away sober. Quitting weed and thinking about changing to cbd i was wondering if it would be beneficial to that? Like to what extent does cbd sedate you or just calm you down? I‘m sick of struggling to feel my sadness and would hate to see cbd worsening the dissociation
I would also guess it depends on the strain perhaps? Are there any recommendations maybe?

Thanks in advance!!

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u/Stunning-Start-8108 — 7 days ago

qual laboratório é melhor? primeira vez comprando

me ajude!!!! no receituário tem “Canabidiol 50mg/ml” tratamento de dor crônica

u/Medical_Afternoon324 — 6 days ago

Are Premium CBD Vapes Worth It? Considering TribeTokes and a Few Others

I've gone down a serious reddit rabbit hole over the last week trying to learn more about premium CBD vapes. Every thread seems to tell a different story.

One person says premium brands completely changed their experience. The next person says they switched back to a cheaper brand because they couldn't tell any difference.

That's why I'm posting here.

One name that kept showing up during my search was TribeTokes. I've also seen recommendations for Secret Nature, and CBDfx. They all seem popular but popularity doesn't always mean better. What I'm really trying to understand is whether premium CBD vapes provide enough extra value to justify the higher cost.

For those who've used them consistently:

  1. What made you stick with a premium brand?
  2. Did you ever switch back to a budget option?
  3. Was there a noticeable difference in quality or effects?
  4. If you had to start over today would you buy the same brand again?

Tbh I trust user experiences way more than review sites these days.

Would appreciate any honest feedback good or bad.

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u/Zealousideal-Lunch53 — 8 days ago

CBD for intrusive thoughts & OCD like symptoms

hi, i'd like to know if anyone has had success with using CBD to manage intrusive thoughts and compulsions?

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u/mike_836 — 9 days ago

CBD oil and sleep

Recently my country has decided that ultra low/0% THC containing CBD flowers are no longer allowed to be sold. I could get a prescription for THC cannabis but I don't want that

So I went and bought some oil 35% CBD and CBG

Its certainly helping pain management as well as smoking the buds; it's no worse or better, and my partner is finding it very good at reusing anxiety and is falling asleep very quickly

However my insomnia has come back. I'm taking hours to fall asleep (3-4 hours) and I'm waking up several times in the night. I'm utterly exhausted

Last night I broke out the one remaining pack of bud we have (I hadn't realised that the ban was coming, so didn't stock up 😭) and slept much better. I don't smoke much, only 3-5 a day

I can't go back to terrible sleep. After 25 years of insomnia, to finally have found something that truly helps (even if I end up with lung or oral cancer from smoking) it's been amazing, I don't want to go back to how I was

What would you recommend I do when this packet is finished?

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u/RutabagaCreepy3297 — 12 days ago