Supratherapeutic INR >10 Admission vs Discharge
I’ve got another one for the community. in a patient with an INR >10 without signs of bleeding, do y’all generally admit or discharge with close outpatient follow up?
Specific case prompting the question: 50s male with TAVR 2 weeks ago for infective endocarditis cause symptomatic regurg, small septic emboli stroke 4 months ago without residual deficits, also on linezolid and amiodarone (cytochromes in shambles). Supratherapeutic INR on routine outpatient labs, medical sub specialist sent patient to ED. verified INR. No other lab abnormalities. Received oral vitamin K. Patient has ability to get lab draws tomorrow and to follow up closely with PCP. Partner able to monitor patient at home.
Couldn’t find any solid literature about bleed risk in the acute/ED setting beyond that there’s more risk. Got a wide variety of impressions between ED docs, hospitalists, and pharmacists.