r/ureaplasmasupport

my main symptom was primarily an ammonia smell. it went away for a few days but is back. my doctor wants me to wait four weeks to get retested before prescribing more medication but the first round was only a 7 day doxycycline course.

I just saw that Wisp will prescribe two weeks doxy for $40. i’m wondering if i should just do that so i can start getting this taken care of.

is waiting for another test the best move? is wisp the best online prescriber? cost is a concern for me.

Why is there so little information about pristinamycin here? Can you please tell me how should I take it if I can get it? Has anyone been cured by it when everything else failed? Is it dangerous like the quinolones?

So i got tested positive for ureaplasma in January. Took doxycycline 7 days and later for a month with azithromycin. And it came back again now in prescribed moxifloxicin for 21 days I'm taking with NAC and i swear to God i have having weird moving pain in all my joints some day it's in one joint next day or next hour in another joint.
Also some pain in my balls now i nev3r had pain in my balls since January but these 4 days are being cruel to me.
Help me if anyone been through that and what did you do? Of course I'll visit doctor too if it gets worse but it's kind of moving pain for me. And it does hurt yeah. Since my job is not office job where i can just sit.

Full Text (since paywalled):

Farrah was fed up with her vagina.

For the past two years, the 29-year-old dancer from Ohio had been dealing with severe pelvic pain and vaginal odor. “It was like 8/10, horrible core pain,” she says. “I couldn’t lie down. I couldn’t even work an office job. It was bad.”

When she visited doctors, she told them what she thought the culprit was: an allergic reaction to soy oil in a vat of water she’d swam in during a pirate-themed dinner theater performance. But they didn’t believe her. “They attempted to fix it with antibiotics,” she says. “And they just did nothing.”

So Farrah (who requested we withhold her full name to speak freely about health matters) started Googling her symptoms. That’s how she stumbled on NeuEve, a vaginal health company that provides supplements, suppositories, and at-home vaginal microbiome testing kits.

She ordered a test from the company for $150, and it came back with a diagnosis: aerobic vaginitis (AV), a bacterial infection caused by an overgrowth of E. coli or streptococcus. She ordered supplements the company recommended, and she says the pain abated almost immediately. “I was just so glad to actually know what was wrong,” she says.

Farrah is one of a growing number of women who have used at-home tests to self-diagnose issues with the vaginal microbiome—an ecosystem of bacteria growing inside the vagina; the presence of “good” bacteria correlates with lower risk of STIs and other types of infections, according to numerous studies. The industry got a shoutout when the Silicon Valley entrepreneur Bryan Johnson recently posted on X that he had just given oral sex to his girlfriend, Kate Tolo, then followed up with a screengrab of her Tiny Health vaginal microbiome report. He proclaimed that she scored “100/100” and that hers was in the “top 1% of all vaginas” due to the dominance of Lactobacillus crispatus, a type of “good” bacteria found in the vagina.

Johnson’s thread garnered widespread mockery, with many questioning why Johnson would publicly quantify his partner’s vaginal health in such a fashion. But it also received replies from women online who are tracking their own vaginal microbiomes to treat their bacterial infections, to boost fertility, or just out of interest. Some even posted their results.

The market for at-home vaginal microbiome tests is growing—Tiny Health, the startup Tolo used, claims vaginal health testing sales spiked 2,000 percent within the first 48 hours of Johnson’s post—and similar companies include Juno Bio, which partners with Neueve; the UK-based Daye, and Evvy. But some experts believe there’s not yet enough research to support the long-term validity of such tests. None of the at-home kits on the market are approved by the FDA. There are also questions as to whether they empower women to take their health care into their own hands or simply create more anxiety for them.

Twenty-eight-year-old Samantha (she also requested a pseudonym given the sensitive nature of this topic) developed an interest in vaginal microbiome testing after experiencing a bout of bacterial vaginosis, or BV. She ordered a testing kit from Evvy upon the recommendation of the Facebook group Beyond BV, which offers support for women with recurring vaginal infections, and where they often post their own results.

Samantha found her test results useful, but she also noticed a distinct strain of paranoia within the group. For instance, when many women receive their results, they tend to focus on whether they have enough Lactobacillus crispatus, or “good” bacteria, in the vagina. “I'll read posts where women are freaking out if they have like 97 percent crispatus and then they'll retest and they'll have like 60 percent and be really disappointed and scared,” she says. The opposite also holds true. “Women will post about having 100 percent crispatus and other women in the comments will just be like, ‘Oh, I'm so jealous, I'm having so many issues, I hope to be you one day.’”

In internet communities like the subreddit r/Healthyhooha , which has more than 100,000 members, women regularly discuss their ratios of “protective” to “destructive” vaginal bacteria, often trying to optimize the former. Some take vaginal microbiome tests multiple times, as a preemptive measure to avoid future infections. Research indicates that 50 to 80 percent of women who get BV once will get it again.

Longevity researcher Kayla Barnes-Lentz tests her vaginal microbiome about twice a year and publicly posts her results. (She also uses Evvy and acts as a paid adviser for the brand.) She started testing it not because she has any underlying health issues, but because she wants to do everything in her power to try to boost her numbers—for instance, she says she got her 97 percent protective bacteria score up to a 100 percent by taking vaginal probiotics.

“We know that decline occurs as we age, and I want to be as protected against that as possible,” she says. “I’m always striving, and I’m always in competition with myself.”

Evvy founder and CEO Priyanka Jain says the company has served more than 100,000 patients since its launch in 2020. She says that while the vast majority of her customers struggle with preexisting vaginal health issues, 10 percent take the test out of “curiosity,” and more than 50 percent are regular subscribers, taking the test every three months, either to track their fertility or prevent recurrence.

There’s a paucity of research surrounding the vaginal microbiome in comparison to the much better-known gut microbiome. This is in part due to gender bias within the scientific research community, says Hana Janebdar, the founder and CEO of the vaginal microbiome testing startup Juno Bio. Historically, “there has been this huge amount of research and commercialization into every aspect of microbiomes except how it pertained to women's health,” she says.

But even though recurring BV infections among women are a legitimate issue, some researchers say the utility of taking an at-home vaginal microbiome test is debatable—especially when one is asymptomatic, as Barnes-Lentz and Tolo were.

The vaginal microbiome is ever-fluctuating and can vary depending on factors like diet, sexual activity, and whether someone is pregnant or menstruating, says Jacques Ravel, a vaginal microbiome researcher at the University of Maryland. (Ravel is also listed as a scientific adviser to probiotics company Seed.) “It’s a very dynamic system,” he says. “Knowing what happened at one point in your life won’t really tell you much about what’s going to happen even two weeks from now.”

Vaginal microbiome diversity also varies by race and ethnicity: Black women, for instance, are statistically more likely to have less Lactobacillus crispatus, the protective bacteria, than white women of European descent, but that doesn’t necessarily indicate a problem with their vaginal health. And some women can have little to no lactobacillus and be perfectly healthy.

The tests also typically suggest treatment protocols like antibiotics or probiotics, some of which can disrupt the bacteria ecosystem in the vagina if introduced unnecessarily. “You're going to maybe end up with something that might not be optimal for you, and all of a sudden you're going to start having problems,” such as worsening irritation or discomfort, Ravel says. “I think that’s dangerous.”

When asked about such critiques, the CEOs I spoke with take issue with the idea that the tests provide zero insight into long-term vaginal health, arguing that results fluctuate far less than Ravel suggests. While Kimberley Sukhum, the chief science officer at Tiny Health, agrees that unnecessary treatment such as antibiotic intervention “can be harmful,” she says biomarkers such as lactobacillus dominance are “not fleeting signals. They reflect the underlying character of a woman’s vaginal community at a given point in time and are associated with real health outcomes.”

Regardless of the long-term utility of the tests—or, at the very least, the ludicrous idea of a woman having a “top 1%” vagina—their popularity undoubtedly points to a larger issue within the women’s health space. Until 1993, researchers were not legally required to include women in clinical trials, contributing to a massive gender gap in data. The women who regularly test their vaginal microbiomes are trying to find their own answers within a medical system that has largely failed them.

“We have not done extensive research or funded enough for extensive research to come up with new medicine to solve this problem,” says Ravel. “For almost 50 years, we have not come up with a solution to help women. And I think that’s very, very sad.”

First time poster.

Finished a 7 days 100mg doxycycline 2x a day and one day 250 mg azythromiacin a week ago.

Still having symptoms (but tested positive for yeast so taking flucanazole). Concerned the treatment didn’t work and wasn’t long enough because I can’t really tell if it improved. I’ve been having symptoms since September (9 months of gaslighting YAY :D) that come and go, mostly burning pee and sort of foamy/white bits in urine, plus pain after sex.

Urogynecologist told me to get re-tested a week after antibiotics, which kind of makes me not trust her… because afaik test of cure is supposed to be 3+ weeks after treatment?

Also, nervous that my IUD might reinfect me?

Let me know what you lovely people think… should i ask for more antibiotics? Should I remove my IUD to avoid risk of bacteria lingering and reinfecting me?

Also, I gave my partner 7 days of doxy, but should I have him take the azithromiayn after as well? He was asymptomatic.

Thanks!
<3

Fighting this infection unsuccessfully so far. Going in 6 months. Painful urethra. Done 2 rounds of doxy.

Ciao ragazzi, sono nuova e qui ho trovato le uniche informazioni veramente utili, spero ci sia qualcuno che possa aiutarmi.

Ormai due mesi fa vado dalla ginecologa per un prurito vaginale e delle perdite bianche e inodore, la classica sintomatologia da candida e lei mi cura come se fosse candida. Dopo qualche settimana i sintomi tornano e peggiorano, presentando anche l’inizio di quello che sarebbe stato il mio inferno: la cistite.

Non soddisfatta faccio un tampone vaginale (che risulta positivo a gardanarella, klabisella pneumoniae e UREOPLASMA PARVUM) e un’urinocultura che però risulta negativa.

Io mi ero già informata su questo ureoplasma parvum, per una corrispondenza con i miei sintomi ancor prima che uscisse il risultato del tampone, e quindi sapevo che solitamente si cura con la doxiciclina o l’azitromicina. Niente di tutto questo mi è stato prescritto, quello che mi è stato prescritto è stato:

-ovuli di chemicitina 500mg + cefixoral 500 mg

ma non mi è servito a niente per i sintomi urinari e quindi mi è stato prescritto:

-ciproxin 500 mg

Anche questo inutile con i miei sintomi urinari, ho contattato 3 ginecologi diversi negli ultimi 2 mesi, ormai quasi 3 mesi, e ancora niente. L’ultimo ginecolo, visto i miei sintomi imperterriti agli antibiotici mi ha prescritto terapia di integratori e ovuli vaginali a base di pre e pro biotici e il D-mannosio: non funziona neanche questo.

Io sono convinta che la causa del mio problema sia il batterio che non è stato trattato correttamente e che i miei sintomi urinari derivino da lui: dall’ureoplasma parvum e dall’assenza del ciclo con il doxy.

Non so a chi rivolgermi per avere un parere valido, che dovrei fare? Contattare un urologo? Fare un tampone con PCR per l’ureoplasma? Se volessi prendere doxy (richiesta che i miei ginecologi ignorano e rifiutano) come dovrei fare per capire il dosaggio giusto? Dovrei chiedere a il mio medico di base?

Scusate io sono disperata, ogni giorno da ormai due mesi sento questo stimolo urinario 24/7 e sta rovinando sul serio la mia qualità di vita. Spero ci sia davvero qualcuno che possa aiutarmi a tornare alla normalità

AZITHROMYCIN GUIDELINES

A question that gets asked often here is about how to take Azithromycin after doxycycline. First off, usually when we reference how to take it, we are talking about the CDC guidelines for mycoplasma (ureaplasma is in the mycoplasma family). So that’s easy to google.

FOR EASY REFERENCE:
- 2.5g total is the standard

- 12 hours after DOXY: You take 1g (that might be 2 pills, maybe 4. Do the math depending on what dose your pills are!! Often 250mg or 500mg)

- then you take 500mg daily until they are finished (usually 3 days)

https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm

In general, please utilize the resources of this group, especially the info guide if you’re new to this infection. All the pinned posts at the top of this subreddit have a plethora of info.

We didn’t have the azithro guidelines “officially” posted anywhere though so here they are.
The fact that the guidelines often prove unsuccessful and we tend to advocate longer treatments here is a separate issue…

hi recently got diagnosed with ureaplasma, im doing 7 days of doxy and azithromycin 500 for 4 days. my symptoms have definitely improved but the strong fishy odor is still there. i tested negative for all std/sti.
my symptoms before:
discharge
pelvic pain
back pain
pain while urinating/urgency to urinate

when can i expect the smell to go away? is there something i am missing?

I just tested positive for ureaplasma after almost 9 months of symptoms and a few positive tests for BV that were treated. The BV tests are now coming back negative but now I have to treat the ureaplasma. I have mild symptoms: mainly discharge and occasionally some dull pain. I also have autoimmune issues that have been flaring nonstop the past 2 months so I’m quite certain my immune system is in pretty bad shape. Currently trialing a new med for this and being super careful about my diet & taking probiotics daily.

My gyno prescribed me moxifloxacin 400mg for 7 days. I’m traveling abroad in 10 days with no clue when I’ll be back in the states (going to care for my dad who has stage IV cancer and is likely going to pass soon). From what I’ve read, a 7 day treatment is usually not enough. Has anyone gotten rid of this with a short treatment? Should I ask my doctor for a longer treatment in case? I feel annoying because I sent her a few messages today when I got the results because I was super anxious and already requested a diflucan prescription in case. Any advice is much appreciated. Thank you all in advance.

Edit: to add I’m extremely sensitive to antibiotics especially doxycycline that’s why she opted for the moxifloxacin. I’ve never taken it so we’ll see how that goes but I’ll suffer through the side effects in hopes of getting rid of this nightmare😞

“I’VE JUST BEEN DIAGNOSED. NOW WHAT?”

I’m putting this info out there, all in one place, for people who need general guidance on where to start with this infection. Please read throughly!

*Please be aware there really are no standard guidelines for ureaplasma in most countries. You can look up the CDC guidelines in the USA for mycoplasma. Ureaplasma can potentially be treated with the same antibiotics, as they are in the same family*.

The general consensus here, however, is that those guidelines are not sufficient. The advice here is just that. ADVICE. Based on opinions and experience. We are not doctors and nothing here should be considered medical advice. This is why it gets complicated to post a specific protocol.

But here are *my personal opinions* on approaching ureaplasma after an *initial diagnosis* (this advice is not necessarily for chronic suffers and especially those who have failed multiple treatments):

1.) HOW SHOULD I TREAT?
Short courses rarely work.
14 days doxycycline and 2.5g of Azithromycin is often done by people here as an initial treatment. This is slightly longer than the CDC protocol.
I don’t think this has a high success rate.
I tend to recommend 28 days doxy and 7 days Azithromycin as an initial treatment. But if you are worried about extended antibiotics or don’t tolerate antibiotics well, you can try this first.

Please see our post on how to take the standard dose (2.5g) of Azithromycin, if you go that route, because many people find it confusing. You should take a longer course the same way, you’ll just be doing it longer.
https://www.reddit.com/r/ureaplasmasupport/s/Oj2o8B5cxk

Fluoroquinolones such as Moxifloxacin should be reserved for after this treatment has failed, as they come with a risk of severe side effects (please research if you’re considering this class of antibiotic).

2.) SHOULD MY PARTNER ALSO BE TREATED?
A resounding YES. This is an STI. Men are often asymptomatic and test negative. Doesn’t matter. If asymptomatic, the 7-14 days doxy and 2.5g may bend sufficient but we really don’t know for sure and when they are asymptomatic, it’s very hard to know if they are actually cured.
No sex should happen until both partners are symptom free and negative (6-8 weeks post treatment).

3.) WHY MIGHT WE NEED ANTIBIOTICS FOR SO LONG?
You do not want to PARTIALLY treat this bacteria. It’s a tricky, teeny-tiny little intracellular bacteria and it will make it difficult for you.
This is the biggest problem we see here. Doctors prescribe ridiculously short courses and people end up with symptoms that haven’t fully resolved or go away and then return days or weeks later.
IF YOU ARE SEEING IMPRPROVEMENT on your antibiotics and are not completely symptom free towards the end of your course, PLEASE ask your doctor to extend it!
Way too many people here stop before they are done! This is a recipe for a resistant infection embedded in biofilm. Not. Good.

There is a reason doctors and all antibiotic inserts instruct people to continue their course until the end even if symptoms are gone. Why?? Because there can be low levels of bacteria still there once your symptoms go away. You have to continue the medication further in order to eradicate it.

So if you are not even symptom free on antibiotics, you’re DEFINITELY not done! (This is assuming you are seeing noticeable improvement. If you are NOT noticing improvement within 2 weeks, you may need an alternative antibiotic. Please be aware that everyone is different in when they tend to respond to treatment.)

4.) I’VE HEARD LINGERING SYMPTOMS ARE NORMAL AFTER ANTIBIOTICS
The philosophy of this group is that lingering symptoms mean something is still going on. The philosophy of this group is that testing is not accurate after treatment. Trust your symptoms.

5.) WHEN DO I RE-TEST?
You want to attempt avoid a false negative, which is extremely common. I wouldn’t trust anything prior to 6-8 weeks post antibiotics. I’d trust a negative even less at that point if I still had symptoms.
DONT SIT AROUND IN PAIN. If you are still experiencing symptoms, go ahead and test for all other possible infection 7-14 days post treatment.
If they are negative or if treating what shows up doesn’t help, I’d assume it’s still ureaplasma and try to get back on treatment asap.

6.) I DONT HAVE SYMPTOMS, DO I HAVE TO TREAT?
Reasons to treat if you are asymptomatic:

- you’re trying to get pregnant or would like to in the future. Ureaplasma can cause infertility, miscarriage, and pre-term birth in some cases.

- you’re not in a committed relationship with one person (who is ALSO asymptomatic). Even if you’re asymptomatic, you can pass it to other sexual partners, who may not be so lucky. If your partner has symptoms but you do not, you’d want to treat to avoid reinfecting them.

- you have reoccurring BV or yeast. Or you have been experiencing infertility. These ARE symptoms of ureaplasma.

7.) MY DOCTOR WONT TEST FOR THIS OR REFUSES TO TREAT IT APPROPRIATELY
Most doctors still do not acknowledge that ureaplasma can be pathogenic. This is common, regardless of what country you’re in. I am in the USA however so my advice on this may not apply to everyone here, unfortunately. There are a few ways to approach this:

For treatment-

- Use an online pharmacy. TelyRx is recommended here a lot. They have good, sufficient quantities of doxycycline (and minocycline). But there are many others. Google.

- Put serious effort into finding a doctor who will at least be open minded and listen to you.

- Seek out a chronic specialist. They aren’t perfect but pickings are slim. They are more likely to treat with extended or long term antibiotics and not brush off your symptoms. Here are the ones I know of:

- Dr Stewart Bundrick (UTI only, no vaginal issues, offers virtual appointments after initial visit)
- Dr Ryan Heer (fully virtual)
- NY urology
- Artemis Clinic at Harley Street (UK but has virtual options, primarily a UTI clinic)

For testing -
There are many at-home microbiome tests you can order. Microgendx, Juno, Evvy, Daye, and more. Again, Google.

Do your own research, browse the group. There is a plethora of information here! It’s important to educate yourself and decide what opinions resonate with you.

Last year in April I noticed excess amounts of discharge thinking it was BV or Yeast infection. (I get those infections a lot). I went to planned parenthood they said I had CV. I did recommended treatment Got retested at planned parenthood good, the CV was treated. I was still having symptoms. My mistake was going to planned parenthood repeatedly and not an obgyn for the first couple months. I started experience bleeding between periods, stool with mucus, watery discharge, thick clump discharge, sharp pelvic pains, a fishy taste in my mouth thick white oral thrush, painful periods. October 29th, 2026 my gyn does PCR test for Ureaplasma/Mycoplasm. Also does full panel STD/STI test. Ureaplasma Parvum came back positive on Nov 3rd 2025. Nov 5 2025 I start doxycycline 100mg x 2 pills a day x 7 and Azithromycin 500mg I forgot the dosage and time I took it. I get tested again Dec 23,2025. Negative Result came back Dec 28th,2025. Within that time frame most of my symptoms subsided but I was still experiencing pelvic pain, bleeding between periods, diarrhea and watery discharge. my stool has mucus and is very concerning looking. Inform my gyn and pcp. PCP refers MRI. I go in for appointment February 10th, 2026. Results come back February 12th, 2026. Results are negative, except for nabothian cyst on cervix. March 25, 2026 I get PCR and also get Pap Smear done. Results come back 3/28/2026. Everything is negative. Im still experiencing symptoms so gyn schedules biopsy. Biopsy is done April 28th 2026. Results are negative does not show any signs of endometriosis, hyperplasia, atypia, or malignancy. Still having above symptoms. The male obgyn said it’s residual and try birth control for my hormonal changes and pain pills for pain management. I know it’s not what he’s making it seem it’s racking my brain. I’m not sexually active have been in almost a year. I’ve never experienced this before I don’t know what to do.

Advice!
Will 500mg of Azithromycin for 1 day and then 250mg for 4 days be enough to cure my ueraplsma.
I was on doxy for 14 days 5 months ago to treat suspected pid which was actually misdiagnosed as I have found out recently I have actually got ueraplsma parvum, bv and thrush.
I’ve been having symptoms for over 2 years since the I had a coil put in and taken out.
My bf will be receiving the same exact treatments but I’m scared it’s not going to work and we have to do the treatment again and my bf won’t believe that this is not from me cheating - I haven’t and I’m he hasn’t.

My main question is will this be enough to cure it alongside the bv and thrush medication and not having any sex with him for 4 weeks until the test of cure.

It’s really stressing me out that it might not clear it because the 14 days of doxy and metro did not change a single symptom of mine but I would have been reinfected by my current partner because we were unaware of the actual cause of my symptoms. And now both of us will be treated at the same time.
I just don’t know what to do and want this to be over.
Would it be beneficial for me only to do 7 days of doxy following Azithromycin will it get rid of it for me and my partner

Many thanks

Hi everyone!! A year or so ago we started doing Zoom support meetings every month or so, but it’s been a WHILE! A few people have expressed interest in doing one again, so let’s do it!

In the past, these meetings were always a low key, friendly, no judgment, supportive place where we can share our stories, advice, and see real faces of real people who are also battling this infection. If you need support and want to connect, join us!

**Please RSVP on this post** and you will be added to our group chat. *We will only send the zoom link to that chat*, just before the meeting. So please make sure you are checking Reddit around then! And please do not RSVP unless you have a legitimate intention to join (I realize life happens sometimes and people have to cancel but let’s keep the true intention there at least!)

**Zoom meeting: Saturday May 16th at 2:00pm central standard time (CST) USA**

Hi guys, does anyone have any studies or information about Ureaplasma infections in newborns?

Hi everyone,

My issues began 2 weeks ago. I started having symptoms of a UTI (frequency, bladder pressure, cloudy urine, white specs in urine, strong smelling urine) I also had discharge that was coming out a ton and some of it had white chunks in it. I got a few urine cultures done and everything came back negative. Then, my gyno sent out the swab test and it came back positive for ureaplasma parvum. I’m on doxycycline now. All of this started after having sex with a new partner. I was completely fine and symptom free before. I’m just wondering if ureaplasma can cause all of these symptoms to happen. I’m scared, confused, and I feel alone :( this has been terrible

Hi Reddit!

I can’t believe after all these years of watching Reddit story videos I have never posted but here we are with my first post asking for some advice.

My copper IUD was just recently expelled and in the process I found out I have ureaplasma. I have 0 symptoms except for a little bit of itchiness so I was pretty surprised.

Here’s where I need your help. One of my best friends is getting married this weekend and I’m a bridesmaid. I really want to be able to drink freely and enjoy the wedding. I’m wondering if you all think it might be OK for me to start the meds (doxycycline) on Sunday when the weddings over? Today is Tuesday. Based on what I’m reading from you guys it seems like it’s a pretty difficult infection to treat but I’m having no symptoms so I was wondering what you all think