u/Anonym_Talker

I would like to read where this come from. It looks like all Doctors dismissed any patient experimentations with food or vitamins and argue they need therapy or a medication. Is there someone here, that can tell me in which course you have learned that? And in which school book. I assume this is public knowledge, available for peer review, right?

So, where do they learn that?

Right now, Doctors had actually made more harm to my health, with no improvement. And reddit users, with their experimentations and personal research. (and me reading them open minded) Actually helped me.

The question is not about if Doctors are wrong, its about where do they got their false beliefs?

Where, what course, which book, etc... I want the source.

Hi guys, I am at my very last mile of stopping all my meds, after successfully stopping propranolol, Lemborexant/Daridorexant and gabapentin, I've finally stopped Buspirone.

It was the cause of my panic attack for the last 6 Months, Gabapentin was actually patching some of the headache and panic that the med gave me. No Doctors confirmed that any of their meds could give me any of these side effects, and all wanted to either give me more meds or switch meds, and asked me to go in therapy because its du to my "GAD".

Anyway, I've stopped Buspirone 2 weeks ago, and I am meds free since. I had no episode of headache or panic attack since, thus re-inforcing the fact that it was indeed Buspirone that was maintaining me in that state.

Now, what this last 9Months of medication gave me is:

- No plaisure anymore

- numb sex and no libido. (not low libido, NONE)

- And today, extreme sadness. (its been a week, but today is bad...)

I am not suicidal, I am pretty sure its from stopping buspirone... I am here to ask you, how long does it take to pass... I am asking specifically about the extreme sadness... I read enough on PSSD and I accepted that it might takes months to come back, and also that it might never come back... but for the sadness... same!? Its disturbing.

Also, don't waste your time writing that its the ultimate proof that I need medication or therapy. I was in much better shape before starting any of it. I didn't trust the psych med industry before, and even less now. I profoundly regret not trusting my guts in the first place.

Hi Guys, I come back here, because my Doctor is pretty clueless. I was on 4 differents medication last winter, and I finally stop all of them, except buspirone. they have "diagnose" me with GAD, but in fact, I was just having paradoxical reaction from TTFD B1... It's crazy to see how clueless they can be.

Before they put me on all these meds, I was starting to get better, (I had stopped all of my supplement, just in case it was 1 of them causing the panic... and it was) after 4 months, when I got better, I restarted my supplement 1 by one. (basically, multi, vit D, Mag, zinc (and now copper) and omega 3) Nothing "crazy" and I was fine.

Then, I re-added the TTFD B1, smaller doses, but I started to have the same kind of "panic"/overactivation symptoms, (I had to go to ER again, so they can tell me its my "panic" and that I need a therapist. LOL.

Any way, now I know, and I am off the meds. I was starting to panic after taking gabapentin, and if I didn't take gabapentin, so that was the one to stop first!

I kept buspirone because it gave me motivation in the morning. like a small dose in the morning, with a small coffee, was amazing, I felt normal, like all of those people out there. That was amazing. BUT, I started to have to lower my dosage, so much that I am now at 2.5mg 2 times a day, and now, even at that dosage, I start to have those annoying headaches, the kind of headache that makes me panic... After all that time, could it be buspirone that was giving me those panic!? and that the other medication I had with it was actually balancing out the panic created by buspar?!?

Should I just stop Buspirone?!? Since I might not need it at all after all?!? Can this med stop working properly? does that mean that I don't need it anymore? or its the yo-yo of the recent weeks that gives me those very unpleasant "panic headache"?!? I think I was fine at 2 times 2.5, and after stopping gabapentin, I wanted to go back at 5mg 2 times a day, because this was the dose I had that was helping me the most with my motivation issue. but when I did, I started to panic again and started to have huge headache. I've heard that its a med that people can take PRN, is that true? I mean... if that's the case, what is going on!? the med was only working well for me when I was on gabapentin too!? that means, its not a good med for me after all?!?

Any help is welcome. Its been a 8 Months journey, I would like to go back to my life and be normal again.

how long after stopping the medication shpuld I get my libido back?

I took sertraline for 2 weeks, 9 Months ago. it killed my libido and evem after stopping it, it never came back...

Anyone here have a positive story about PSSD?!? I am afraid that's its just the new me, and that the medication just killed my sex life for ever.

I've been on buspirone which was supposed to help since, with no good results. now stopping all med, I do not believe ineds anymore, that a crooked business.

Hi Guys, I come back here, because my Doctor is pretty clueless. I was on 4 differents medication last winter, and I finally stop all of them, except buspirone. they have "diagnose" me with GAD, but in fact, I was just having paradoxical reaction from TTFD B1... It's crazy to see how clueless they can be.

Before they put me on all these meds, I was starting to get better, (I had stopped all of my supplement, just in case it was 1 of them causing the panic... and it was) after 4 months, when I got better, I restarted my supplement 1 by one. (basically, multi, vit D, Mag, zinc (and now copper) and omega 3) Nothing "crazy" and I was fine.

Then, I re-added the TTFD B1, smaller doses, but I started to have the same kind of "panic"/overactivation symptoms, (I had to go to ER again, so they can tell me its my "panic" and that I need a therapist. LOL.

Any way, now I know, and I am off the meds. I was starting to panic after taking gabapentin, and if I didn't take gabapentin, so that was the one to stop first!

I kept buspirone because it gave me motivation in the morning. like a small dose in the morning, with a small coffee, was amazing, I felt normal, like all of those people out there. That was amazing. BUT, I started to have to lower my dosage, so much that I am now at 2.5mg 2 times a day, and now, even at that dosage, I start to have those annoying headaches, the kind of headache that makes me panic... After all that time, could it be buspirone that was giving me those panic!? and that the other medication I had with it was actually balancing out the panic created by buspar?!?

Should I just stop Buspirone?!? Since I might not need it at all after all?!? Can this med stop working properly? does that mean that I don't need it anymore? or its the yo-yo of the recent weeks that gives me those very unpleasant "panic headache"?!? I think I was fine at 2 times 2.5, and after stopping gabapentin, I wanted to go back at 5mg 2 times a day, because this was the dose I had that was helping me the most with my motivation issue. but when I did, I started to panic again and started to have huge headache. I've heard that its a med that people can take PRN, is that true? I mean... if that's the case, what is going on!? the med was only working well for me when I was on gabapentin too!? that means, its not a good med for me after all?!?

Any help is welcome. Its been a 8 Months journey, I would like to go back to my life and be normal again.

Hi guys,

I am at day 6 today after stopping Gabapentin completely.

I had terrible headache during the night and on waking up. Also back pain and muscle tightness. I survived it. I had to cut on caffeine to prevent being over wired.

I was a little bit depressed on day 5, but that was manageable. It seems that I am less dizzy, vut Instill have my moments. I need to sleep whenever I can, if not, I'll get sleep deprived easily.

Today, I have nerve pain in my legs, mostly thighs and hips... which is unusual for me. I also have constant micro vibration when at rest. This is driving me crazy.

Is this all part of the withdrawal effect!?

I am concerned about the dizziness... If it is not the gabapentin, I am scare that it might be something more serious that was put on the "anxiety"...

Anyway, any cheering 📣 would help me. day 6 is so far the hardest one. I am looking at my bottle almost full and It getting harder not to just take a little...

I stopped because it was giving me headache and panic attack, so I won't... but ho god, I feel like crap taking it, or not taking it...

😭

the micro vibration in my neck/head is so scary...

I was in the assumption that vitamine B1 in the form of HCL was rate limited and thus, less likely to create paradoxical reaction. is that right?

I had a terrible reaction with TTFD, I thought I was ok with Benfothiamine, but now I doubt, so I took 200mg of B1 HCL alone last night and this morning I that same annoying headache...

Anyone having such a reaction with B1 HCL?

Seriously, I am considering to just stop taking ANY form of B1 at this point... That can't be the paradoxical reaction going on for MONTHS!

ER says I am fine, the doctor at the clinic sent me there asap after seeing a video of me having convulsions, that is probably PNES...

I wasn't sharp with my buspirone intake, so I restarted to take 2.5mg 2 times a days.

for the last 2 days, randomly, I have bouts of micro fall, that accompanies my dizzy moments.

its like one of my leg is suddenly super heavy and I kinda failed to lyft it as high as I normally do when walking. When that happens, I generally have to sit or lay down, it is traumatic if I can say...

Is this what you all called "Dizziness" from buspirone?

I used to have a feeling that the floor is falling, like an orthostatic pressure drop, but this is kinda new...

I can't wait to see the neurologist, I have my legs that are painful randomly, dull nerve pain, not always, often before I need to poop.

I have one of my leg that my toes twitch when relaxing or falling asleep, in the morning it might fully wake me up if I wake up enough, the twitching start.

I know I am anxious, and I just got an emotional rollercoaster, and my sleep is not good right now, but after the PNES seizure like episode I had (its not a seizure, I stay fully conscious...) that new leg that fail to lift is stressing me out. also, when that happens, I feel like my brain is tilting, its hard to describe...

It often after I take my buspirone, like 2-3 hours later.

What is going on, I got all sort of side effect with this med, and at 2*2.5mg, it seems like its worst than at 5mg 2 times a day...

I just want to get better. Can the medication aggravated a nerves issue I had in the first place?

I can't go back to ER seriously, they just laughed at me now. That actually scares me even more... Like, if there is really something bad happening, they won't help me now.

:(

TL;DR

are those "mini ceisure" at night a side effect of tapering gabapentin, or TTFD? or TTFD withdrawal!?

\----

I've been on TTFD B1 last year, and I suspect that's what triggered my initial "panic attack". I've been on many medications since, and got better, to a point where I stopped all my meds, except for low dose buspirone (5mg) and low dose gabapentin (100mg)

I've recently tapered the gabapentin until I stopped for 3-4days. I was doing fine, good actually.

meanwhile, I've restarted the TTFD B1 at low dose, over the last 2 weeks. 12.5mg 2x per day.

I increased to 25mg 2x a day and this is when I crashed again. (Starting to feel super dizzy)

I restarted Gabapentin thinking it was the withdrawal effect starting after 4 days. so I did like 100mg, 2tines a day, then 100mg/day for 3 days.

Then, I started to have terrible headache after taking the gabapentin and I kinda need to taper it and stop it again.

last nigh, and 4 night ago, I woke up in the middle of the night, with a "weird" brain pain-ish, band like headache... then, my whole body started to shake, mostly my legs, but yesterday it was my arm/upper body as well, and my jaw was super thigh.

I can shake like that in total agonie for 30min, then it passes, and I can fall asleep 1h after does episode.

The first night I called the ambulance, got triage low priority and sent home.

My doctor ordered a Neurological test (for my leg twitching, differente problem)

My question here, since does episode feels to me like a partial ceisure. (I "feel" there's a place in my brain that is in a different state than the rest of my brain, like if my brain is half sleeping)

I am going back to see a doctor today, but they really don't know what I have. (they say its a panic attack...)

TL;DR

are does "mini ceisure" at night a side effect of tapering gabapentin, or TTFD? or TTFD withdrawal!?

----

I've been on TTFD B1 last year, and I suspect that's what triggered my initial "panic attack". I've been on many medications since, and got better, to a point where I stopped all my meds, except for low dose buspirone (5mg) and low dose gabapentin (100mg)

I've recently tapered the gabapentin until I stopped for 3-4days. I was doing fine, good actually.

meanwhile, I've restarted the TTFD B1 at low dose, over the last 2 weeks. 12.5mg 2x per day.

I increased to 25mg 2x a day and this is when I crashed again. (Starting to feel super dizzy)

I restarted Gabapentin thinking it was the withdrawal effect starting after 4 days. so I did like 100mg, 2tines a day, then 100mg/day for 3 days.

Then, I started to have terrible headache after taking the gabapentin and I kinda need to taper it and stop it again.

last nigh, and 4 night ago, I woke up in the middle of the night, with a "weird" brain pain-ish, band like headache... then, my whole body started to shake, mostly my legs, but yesterday it was my arm/upper body as well, and my jaw was super thigh.

I can shake like that in total agonie for 30min, then it passes, and I can fall asleep 1h after does episode.

The first night I called the ambulance, got triage low priority and sent home.

My doctor ordered a Neurological test (for my leg twitching, differente problem)

My question here, since does episode feels to me like a partial ceisure. (I "feel" there's a place in my brain that is in a different state than the rest of my brain, like if my brain is half sleeping)

I am going back to see a doctor today, but they really don't know what I have. (they say its a panic attack...)

​

Might makes no sens, but that's the conclusion I am getting to what might happened to me.

I started to have silent migraine and Panic attack After taking 50-100mg TTFD B1 per day.

I didn't make the connection until recently. Since all of those symptoms restarted after I restarted TTFD again, ut was obvious that the cause was TTFD.

I immediately stopped the Supplement, and even after 3 days, I gets the same bad headache, panic like symptoms right after I drink a coffee. So, I dig this down and that's what I came out with. Share your experiences, did you ever experienced that with TTFD? can you have caffeine while supplementing it?

Should I just stop this supplement for ever? or stop caffeine until I supplement?

Also when do we know we can stop supplementing with this form!!?

This explanation here does not explain why Coffee alone after 3 day can trigger the headache again.. can it be?

# TTFD Paradoxical Reaction: D1 Dopamine Mechanism → Headache/Migraine → Anxiety/Panic

## TL;DR

TTFD directly triggers dopamine release via D1 receptor activation (confirmed in rat studies). D1 receptors sit in headache/migraine pathways and follow a bell-shaped dose-response (overstimulation = dysfunction). In people with pre-existing dopamine sensitivity (migraine-prone, addiction history, or thiamine-deficient with poor methylation clearance), this D1 surge can plausibly cascade into headache and, at the extreme, anxiety/panic — though the full chain hasn't been directly studied as a unit.

The mechanism, step by step

1. TTFD → dopamine release → D1 activation TTFD metabolizes into thiamine phosphate esters (TTP/TDP), which trigger dopamine release in the prefrontal cortex. This effect works specifically through D1 receptors — blocking D1 (not D2) fully suppresses it.
2. D1 overactivation → headache/migraine susceptibility D1 receptors are densely present in the trigeminocervical complex — the pathway directly responsible for headache pain signaling. Migraine patients specifically show dopaminergic hypersensitivity, meaning their D1 system overreacts to normal dopamine levels. D1 agonists also show a bell-shaped dose-response: moderate activation is fine, but overstimulation impairs function — consistent with a "too much, too fast" reaction.
3. Compounding factors that push it further Caffeine independently potentiates D1 signaling (via adenosine A1 receptor blockade, forming an A1R-D1R heteromer) — stacking two D1-activating inputs Pre-existing dopamine dysregulation (addiction history) means receptors are already primed to overreact or underreact unpredictably to a new dopamine surge Poor methylation/glutathione clearance of TTFD byproducts (the "paradox reaction" mechanism) means the dopamine surge isn't buffered as quickly, prolonging exposure
4. Headache → anxiety/panic (weaker link) Once D1-driven headache/migraine circuits are activated, the case for anxiety/panic is real but less direct — caffeine-induced panic is documented, but mainly at high doses (400mg+) via a different receptor pathway (A2A-D2), not the A1-D1 one discussed for TTFD. So headache is the stronger, more mechanistically supported endpoint; panic is a plausible but unconfirmed extension. Bottom line TTFD (D1 dopamine trigger) → headache/migraine (documented D1 pathway) is a coherent, evidence-backed chain. TTFD → anxiety/panic is plausible but relies on stacking mechanisms that haven't been tested together — treat that part as hypothesis, not established fact. References Tsujita et al., "Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex," Scientific Reports, PMC6041333. Akerman & Goadsby, "Dopamine and Migraine: Biology and Clinical Implications," Cephalalgia, 2007. Ferré, "An update on the mechanisms of the psychostimulant effects of caffeine," J Neurochem, 2008. ClinicalTrials.gov NCT03305809 protocol (LY3154207) — D1 agonist bell-shaped dose-response. Systematic review/meta-analysis on caffeine and panic attacks, J Psychiatr Res, PMC (S0163834321001614) and PMC12287556.

Hi guys, I am entering the very last stage of this tapering.

I've been on 50mg for the last 3 days, so far its manageable. I was taking it every 20h because its was starting to get very uncomfortable around that time frame.

Today I was able to though it out, and now I have passed the 32h with any dose. I started crying earlier, but I was ok and didn't take anything.

Now I am starting to be shaky internally, but its manageable...

should I just thought it out and stop entirely, or start a 25mg tapering... or continue at 50mg?

I can't wait to be off this med... :(

I need to take a small dose right now, so I'll take 25mg. but then what, I thought it out and stick to 25mg? or take 25mg 2 times a day from now on!?

Thanks in advance. any input is welcome.

since I started TTFD, I react so BAD to high histamine food.

One night it was a left over (3-5 days) and last night it was parmesan cheese...

I gets weird leg crawling feelings and nerve pain its crazy... (and high HR...)

If I take a anti-histamine it calms everything, vut I do not sleep super well... IDK if its a paradoxical reaction to the TTFD...

Anyone had that? Will it pass!? how long, when!?

I am at the hospital right now, my blood test came back "normal". they test the basic stuff only here...

​

Anyone here have had something like that!? I am using such a small dose of TTFD, for weeks, this morning I've increased to 50/3mg instead of 50/4.

​

I can't imagine that's why!?

​

Still waiting to see the Doc, but they are pretty clueless.

​

Right now I can't walk, I start to be super dizzy if I stand up for more than 5min.

​

TL;DR Buspirone make you sad at lower doses, but motivated at higher dosages? like, 2.5 makes you sad, 5mg -> motivated?

Me again... I am still trying to improve my medication. long story short, I was on a bunch of medication, and I was able to stop all of them. I do not have the need for them anymore. (sleep aid, nerve pain killer)

I stopped them because I started to be super sad after taking my morning dose of buspirone.
Since I was also tapering down gabapentin, and stoping other med, I decided to stop all my meds to see where my baseline was at now. So far, so good, I have improved my condition a lot. A LOT.

I needed to start medication because I started to do panic attack almost a year ago. My panic attack are gone, I mostly just have autonomic disfonction right now, due to covid I got last winter... (working on that, but with food adjustment and sport)

That aside, during the 6 months I was medicated, the buspirone gave me so much motivation, I actually started to feel "normal" and I started to understand how people can actually do it in like. I always had to push myself WAY more than anyone else. Hearing "you just have to force youself and go" kind of thing was making me laught at the end. I tried that, but tbh, I needed to force WAY MORE than the average person. Taking buspirone actually prove this to me. I was actually going to the gym almost everyday, on days I felt like not going, I was actually able to "kick myself in the butt" and go, or, I decided not to go because I legitimately needed to rest. (not because of the old constant low motivation I was having...)

Anyway, after a week without meds, (and back to my old, life is so hard situation) I decided to restart buspirone. I started at 2.5mg morning, and 2.5mg mid afternoon.
(when it was working best for me, I was taking 5mg 2 times a day)
I then lowered it to 2.5+2.5 in 2 separate dose, morning and mid afternoon, so I didn't get the dizziness when it kicks in. This is when I started to feel super sad, or depress with the medication.

Today, the same sadness happened after my second dose of 2.5mg. I wonder, is the sadness dose dependant? is going backup to 5mg (one shot dose) morning and mid afternoon might prevent the "sadness" to occur?

I really liked how this medication helped me in my life. I talk about that to my doctor and he says that there is no other med, that could work for me (and I've tried a lot of them...)

Anythough on this? Anyone here on buspirone and also experience something like that while tapering off gabapentin? (I am still tapering gabapentin, 50mg before bed...) The odd thing is that, if its the tapering of gabapentin, the sadness is much worst after taking buspirone...

Doctors don't need reddit and people experiences on meds. Reddit comments are fake. The big pharma study are good. They are paired reviewed by an other big pharma study, so they know its true. Big pharma study are better than real world, real human experience. everyone knows that.

​

Trust your doctor when they say the opposite of what your body is telling you. Ignore your body. take more meds. The best is when you add more meds to counteract the side effects of the other medd you take. That's how you know its working.

​

The more meds you take, the best you are going to feel. Trust me, that's what big pharma study shows.

​

When you have so many side effect that you forget why you are taking those meds in the first place, that's when you know they worked. Don't say that the med didn't help you, its a lie and you know it. If they didn't work, you would not stop them. Everyone knows that.

​

I've stopped all my meds once, and felt so good, I felt like myself again. That was a terrible experience, I hope one day I can go back on buspirone, gabapentin, propranolol, sertraline, Vyvanse, Cymbalta, Prazosin, hydroxyzine, Lisinopril, Lemborexant, Daridorexant.

​

I miss how they were making me feel anxious, depressed, numb, in pain, the headache, the silent headache, the band headache, the seizure like headache, the nausea, the constipation, the diarhea from the med I added to fix the constipation.

​

Always trust your doctor, they know their stuff. You don't need reddit. Reddit is not real.

​

Doctors don't need reddit and people experiences on meds. Reddit comments are fake. The big pharma study are good. They are paired reviewed by an other big pharma study, so they know its true. Big pharma study are better than real world, real human experience. everyone knows that.

​

Trust your doctor when they say the opposite of what your body is telling you. Ignore your body. take more meds. The best is when you add more meds to counteract the side effects of the other medd you take. That's how you know its working.

​

The more meds you take, the best you are going to feel. Trust me, that's what big pharma study shows.

​

When you have so many side effect that you forget why you are taking those meds in the first place, that's when you know they worked. Don't say that the med didn't help you, its a lie and you know it. If they didn't work, you would not stop them. Everyone knows that.

​

I've stopped all my meds once, and felt so good, I felt like myself again. That was a terrible experience, I hope one day I can go back on buspirone, gabapentin, propranolol, sertraline, Vyvanse, Cymbalta, Prazosin, hydroxyzine, Lisinopril, Lemborexant, Daridorexant.

​

I miss how they were making me feel anxious, depressed, numb, in pain, the headache, the silent headache, the band headache, the seizure like headache, the nausea, the constipation, the diarhea from the med I added to fix the constipation.

​

Always trust your doctor, they know their stuff. You don't need reddit. Reddit is not real.

​

Hi! I've been posting in other threads, (gabapentin, buspirone, Lemborexant, Daridorexant, Propranolol...)

Because I thought it was related to my medication, but now I am off everything and its still happening.

I use to be able to nap in the afternoon, and it was the most refreshing sleep I was able to get.

Now, in the afternoon, if I ataet to fall asleep, I come so close to "switch off" but I don't. I kinda feel that "stuff" is moving in me, and my brain kinda wake me up. it can happens 5-6 times, until I finally give up and wake up.

It rarely happens at night.

I think all of that started when I started buspirone. I adjusted my schedule so I don't take it before bed and it was fine. the med also helped me not tonhave to nap in the afternoon, so it was ok.

The problem now, is that since I've stopped all my meds, I can barely sleep 5-6 ours per night and I am exhausted. I really need to nap...

Is anyone here know what I am talking about? I have to tell, I do feel sleepy, I do start to fall asleep. its not at all a problem with that part. its the "transition switch" that seems to be broken. I wake up with the worst headache in the middle of my brain... What is that? a med side effect?

I think I had that all my life, maybe due to hyper arousal because of a C-PTSD, but now it is so bad that even if I stay in bed and keep trying, it won't work.

Any help of any kind in welcomed.