r/Thiamine

It 100% Worked no doubt.

But i still have fatty stool, 80% of time it's brown and 20% lighter. TUDCA, Ox bile, Super enzyme from now foods doesn't resolve it.

Hi again, sorry for another post but this is the only place I can get any helpful guidance!

Been suffering from tingling and burning on and off for 8 months since having gastritis. I was also lightheaded for 7 months which has retreated slightly.

My active b12, mma and homocysteine were all tested and fine so i started a trial of Thiamine hcl 100mg supplementation about a month ago. I took it for 9 days but I seemed to feel worse on it, mainly head pressure, anxiety and upset stomach and I also had a bad migraine during it.

I decided to stop and felt better the first day but since then ive felt awful. Ive had a bit of numbness in my tongue and throat, very low mood, continued stomach ache and neuropathy. Its been over 3 weeks now.

Ive felt that bad and the tongue and throat sensation is so odd ive even spiralled into worries about mnd but think this is mainly health anxiety.

I want to maybe try a lower dose initially but cannot find anywhere in the UK offering 25mg Thiamine hcl?

I found 10mg tablets would that do anything for me? Should I even be trying Thiamine again if it made me feel bad or was that a sign it was doing something?

Thanks for reading.

27M, suplemnting 300mg thiamine hcl daily, for 4 weeks but now my heart rate has gone up like 30 beats per minute, i am taking magnesium and other b vitamins.

I’ve been suffering from Dysautonomia now for over 5 years. I’ve seen every type doctor under the sun and non of them could do anything that moves the needle.

I saw Elliot Overton on YouTube and bought his Thiamine protocol where he recommends TTFD for autonomic nervous system issues.

Has anyone had success with it?

Hello all, hope everyone is feeling well today. I started benfotiamine last September for CFS after a week of high dosing B Complex.

The B Complex had 100mgs of HCL Thiamine in each pill, I took 6 per day and had really incredible results. Felt a little better each day and by the 6th day was perfect. Looked up high dose b complex for CFS/ME and came across thiamine as the possible reason for feeling so well. I had paused taking the B Complex once I felt so much better because I didn’t know what I was doing and wanted to research a bit. Immediately went downhill and was right back where I started a day after stopping the B Complex.

Learned a bit about Benfotiamine so began taking 500mgs immediately, along with 100mgs of B2. Continued with the 300mgs or so of Magnesium glycinate and 100mgs of HCL Thiamine (from the bcomplex with other b’s included). Never felt as good on the Benfotiamine as the HCL, but did respond immediately and began feeling better right away.

I had to stop taking the benfo within a few months due to a strange headache. Severe pain at the base of my skull, like a gripping pain, and severe neck pain. Also experienced severe depression, so severe it made me nervous.

Now, 7 months or so since stopping benfo, that bad headache and neck pain returns if I take any b vitamins, no matter the dose, other than the liquid B12 I’ve been taking all along.

I tried taking amino acid complex but that headache and neck pain kicked in after the second day and stayed at least a week. I tried taking small amounts of benfo to see if I could tolerate it but the head/neck pain starts within hours and stays for days/a week or so.

Anyone maybe have any suggestions? My main issue is fatigue - exercise intolerance and PEM. Lots of other symptoms I suppose but would be so nice to be able to move around a bit more than I am. Not bedridden but unable to work and live normal life. I have recently started a low histamine diet and that seems to be helping the fatigue a bit. I know there are underlying reasons for histamine issues and plan to investigate, but that thiamine HCL helped me so incredibly, I’m hoping I can get back to it.

Again, hope everyone is well. Really appreciate any thoughts anyone may have. Thanks so much for your time!❤️

Hello, I am a 27-year-old male. Exhausted by chronic fatigue and mental lethargy for a long time, I have tried numerous supplements, but the high-dose thiamine therapy I tried most recently was the most effective. I took 500mg of thiamine mononitrate daily for two days, then increased the dose to 1000mg. Two days later, I experienced a tremendous improvement in my mood, recovery of my speech and breathing abilities, and reduction in facial swelling. However, the very next day, I experienced extreme anxiety, facial swelling, and fatigue. How can I resolve this? I am certain that thiamine is a crucial piece of the puzzle I need. Although I am currently taking magnesium, potassium, and other B vitamins, I am not seeing the same effects as before; in fact, my condition is worsening. Is there anyone who has overcome these paradoxical symptoms and maintained good health? I would like to know the solution.

For reference, I am currently taking 100mg of thiamine hydrochloride, and 150mg of benfotiamine caused me erectile dysfunction.

How long should I take high-dose thiamine before I can be sure if I actually need it?

I'm trying high-dose thiamine to see if my fatigue and brain fog could be related to my Crohn's (very mild) or mitochondrial dysfunction. I'm starting to suspect this is not the case. After 3 weeks I feel no difference at all. I started with 1500mg thiamine mononitrate for 2 weeks, then 300mg benfotiamine + 500mg thiamine HCL for 1 week. I also take magnesium, potassium and B2.

The title...

Hi everyone,

It turns out I’ve been B1 deficient for quite some time without realizing it. Whenever I took magnesium supplements, I would suffer from severe insomnia, extreme fatigue, a lack of strength, and so on.

I recently started taking 600mg of benfotiamine and immediately noticed a huge boost in my energy and strength; the magnesium started working better, too. However, a week later, I’m starting to experience issues again, such as poor sleep and irritability...

I came across information stating that a B-complex is also needed as a co-factor. Is that true? I’m worried that taking a B-complex daily might lead to vitamin B6 toxicity. Can I take a B-complex without B6 in it? Or does thiamine (B1) deplete B6 as well?

Does anyone know a lot about this? Which vitamins or minerals are really critical because they might get depleted by my benfotiamine dosage?

Thanks in advance.

The title...

Can anyone recommend me Nutritionists / Practitioners that know about Vitamin B1 supplementation that offer consultations online?

I feel overwhelmed on my own and with my symptoms and want to consult a professional

Hi I’m a 20 year old female, and I’ve been struggling to find a root cause to my symptoms for the past 3 months. One random day I started having EXTREME DPDR, daily panic attacks, terrible anxiety, depression, brain fog, sleep issues, chronic fatigue, low energy, and a lightheaded/dizzy feeling when standing. I got all my blood work done, and the most notable issues were high inflammation markers, extremely high cortisol, fatty liver, severely low vitamin d, and a borderline b12 deficiency. I’ve tried supplementing for both of the deficiency’s, and instead of feeling significantly better, I felt significantly worse to the point I have become housebound for months. I want to preface by saying my anxiety/panic have gone away, but the DPDR is still EXTREME. That is why I don’t leave the house. I recently worked with a functional medicine clinic to get a GI map done. The results came back with a very high overgrowth of yeast. My functional medicine doctor believes this has been the root to all of my issues. I want to know if this is true, and if so can it be treated through diet alone. I’m iffy on taking all these natural herbs/supplements she keeps suggesting. I understand that’s the whole point of being holistic, but my body doesn’t do well with things like that. Please someone give me some answers. Can yeast really cause mental health issues like this, she claimed it’s because neurotoxins are flowing throughout my body due to the yeast build up.

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I’m wondering whether thiamine deficiency/functional B1 deficiency could be a significant part of my long-term severe fatigue and heavy-body feeling (even turning over in bed can feel physically difficult). Looking back through my tests, a FunctionalDX blood panel in 2020 actually flagged an 80% thiamine need, based partly on fasting glucose 6.19 mmol/L, anion gap 18.5 and CO₂ 23.6. My HbA1c was 5.69%, C-peptide 1.10 nmol/L and fasting insulin 79.87 pmol/L, and the report also flagged blood-sugar/metabolic dysregulation. On an OAT in 2023 my urinary lactate was only 6.9 (lab range ≤48), but on the 2024 OAT it had risen dramatically to 326 mmol/mol creatinine; pyruvate also went from 0.81 to 6.7. By Sept 2025 my CO₂ had fallen to 20.9 and anion gap risen to 20.9, fasting glucose was still 5.68, and the report again gave me an 80% thiamine-need score. I’ve also historically eaten a fairly high-sugar/high-carb diet and my health/energy deteriorated substantially after surgery several years ago. I realise none of this proves B1 deficiency, but the lactate/pyruvate + glucose + CO₂/anion-gap pattern has made me wonder about impaired thiamine-dependent carbohydrate metabolism/PDH. I’m currently titrating thiamine HCl low and slow and am at 300 mg/day (100 mg three times daily), alongside a calcium/magnesium supplement and a non-methylated B-complex. I previously tried one capsule/day of TTFD for perhaps ~2 months but noticed no improvement and stopped; I don’t remember the exact dose. I’m considering trying benfotiamine and/or TTFD again after giving HCl a proper trial. For those knowledgeable about high-dose thiamine: does this biochemical pattern look suggestive to you, which form would you favour, how would you titrate it, and what cofactors/labs would you monitor?

Hi all, i have been experiencing weird symptoms all year around which have been unexplainable as all my results have come back normal. All my symptoms started during an extremely stressful period in my life and i thought it was just stress.

I recently asked for a b12 test (in uk) and my current reading is 185NG/L. My Gp called and said this is a lower but normal reading. I have not done a b1 test as of yet but i have a history of alcohol abuse.

I have been experiencing

- parastesia and burning in my legs
- buzzing feet and toes
-internal vibrations
- dizziness when i stand sometimes
- severe anxiety
- muscle aches and pains

Just wondering what you all think and whether my symptoms could be caused by a deficiency.

I took a single dose of 200mg of benfotiamine and have had extreme side effects for the past 3 days. I normally take Thorne B complex with no issue and take 240mg of magnesium glycinate nightly. I have had a headache/neck pain for 3 days straight, dizzy, weak, major insomnia, hives, itchy, rashy. It feels like it triggered a massive histamine reaction. I already have me/cfs from long covid, so this is distressing.

I am continuing the magnesium and drinking coconut water, but think I am going to stop the B complex for now. Also taking anti-histamines for the hives and itching.

Is there anything else I can try? I hope I didn’t trigger mca’s.

27M, started supplementing b1 (hcl) 100mg twice a day 3 weeks ago, have seen improvement but i want the energy my brain had years ago to be back, stress was never an issue for me, i believe when the nerves and brain are strong enough they can counter any stress. But ever since 3 years of undiagnosed b12, b9 and b1 deficiency i have not been myself, first i did 4 months of b12 and one month of b9 (cant tolerate folate), and now a month of b1 with cofactors but i am just tired now.

Is there anyone who can help me understand why /how this could have happened? It’s been 10 months since stopping all supplements and I’m still no better.

MIP measured at 63
MEP 68 down from 87
RV high on lung function tests

Diaphragm ultrasound shows poor excursion but no paradoxical motion.