Would Tempus AI be a good play (Comparison to Guardant)
I believe Tempus AI (TEM) looks interesting relative to Guardant Health (GH)
TEM is guiding to ~$1.6B of 2026 revenue and trades around ~6x sales, while GH is guiding to ~$1.35B and trades closer to ~15x sales. GH is growing faster (~37% vs. ~25%), so it deserves a premium, but TEM is already adjusted-EBITDA positive while GH is still burning significant cash.
Even giving GH a large growth premium, the valuation gap looks pretty extreme. Am I missing a key reason TEM deserves to trade at less than half GH’s market cap? Tempus has a 9B valuation while Guardant boasts an expensive 23B valuation while they both are running similar numbers.
Also one of the most significant places where AI could take off would be in biotech companies like Tempus and AI. Tempus has an extremely large data moat and serve very broad areas of healthcare. They also hit their first GAAP positive quarter and are trending towards profitability. Tempus acquired Personalis for 1.5 billion so that dilution might be a little downside. AI in Biotech would probably be the next place for something to run massively in the future.