u/DeRpY_CUCUMBER

Before Ketotifen, any orgasm would cause a massive flare that would last 2-4 weeks.

Upset stomach, massive anxiety, POTS symptoms I don’t have otherwise, brain fog, irritability, inability to concentrate, waking up feeling like i got no sleep, being extra reactive to food, bad impulse control, hives, flushing, weird social anxiety where I can’t even look someone in the eye when talking to them.

It got so bad I actually broke up with my girlfriend and was abstinent for more than a year. In my opinion, no orgasm is worth weeks of suffering.

I never knew if this was related to my MCAS or something else. After stabilizing on Ketotifen for a couple months, 90% of my POIS symptoms are gone. Im now now convinced atleast for me, POIS is all about MCAS.

The only real lingering symptom I get is feeling extra tired the day after. But it only lasts 1 day. I couldn’t be happier.

I believe that if I were to up my Ketotifen more, I could probably get rid of all symptoms.

It’s weird because Ketotifen has cleared up my POIS faster than it’s helped with other aspects of my MCAS.

Anyway, I know there are a lot of other people in this sub who suffer from something similar, just wanted to share my experience.

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1 mg of Ketotifen has cleared up 90% of my POIS symptoms.