u/Evening_Flower8

See my comment on the post “opioid tone rebound causal”from a few days ago for the theory behind this

To be clear I’m a male in mid-20s and fit

Essentially I’m starting to suspect the hangover effect and fever effect is simply a temporary stop to SIBO interference with the vagus nerve.

Ethanol would be directly antibacterial and fever effect would be immunity waking up towards these gram-positive bacteria that it would typically ignore.

The window of sudden dip in the bacterial products tryptamine, 5HT, Gaba,… which are all dopamine antagonists, would lead the vagus nerve to wake up and vagal euphoria to be engaged

Linoleic acid is a potent anti gram positive agent (and way less toxic than alcohol ), also NaCl in the diet is another one.

Yesterday’s meals were high in omega 6 and salt, starches but zero sugar, and also supplemented with nicotinic acid which enhances bile flow and further inhibits SI bacteria. Intense body high the afternoon until I slept which was then effortless to do. I did notice this never happens if I had high sugar intake.

the past weeks I made 2 posts one on the GABA idea the other on Salsonilol.

It hit me these don’t explain the Fever Effect at all.

This effect has been reported here many times, and in my experience the last time I had a cold with fever 3 years ago was a period where my Qi life force roared back on for an entire week. Much more intense than any hangover effect I had. and I quit alcohol so I don’t even get the HE.

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The way it makes me look in front or even rear cam especially outdoors is horrifying. Skin tone, texture, distortion… like a literal monster or troll

Like if I really looked that horrific then people and kids in public would steer away from me which i confirmed does not happen.

I have heard of complaints on these newer iPhones does anyone have experience with this too.
I want to throw it away and get a midrange Samsung

This guy figured it out 5 years ago

« non-enantiospecific Pictet-Spengler reaction of dopamine and acetaldehyde »

Although it might be much simpler and have nothing to do with gut bacteria, as the acteldehyde post drinking reacts with dopamine to make this bizzare dopamine and opioid activator that is also neurotoxic.

This is technically not a good thing despite being euphoric.

Maybe this is why I stopped having hangover effect or even craving alcohol (I fully quit) since I started Abram Hoffer style mega dosing of flush niacin 2 years ago (neutralizes aldehydes via ALDH)

I somehow stumbled on this years ago and think about it every once in a while.

There’s a research compound that induces potent and long-term enhancement of libido

« induces longlasting sexual excitation in male rats. »

« excessive sexual activity in cats⁸»

« they required fewer mounts and intromissions prior to ejaculation, and displayed shorter intromission and ejaculation latencies as well as shorter refractory periods and intervals between successive intromissions. »

« These observations established that "hypersexuality," increased aggression, and perceptual disorientation are sequelae of the chronic administration of the drug in cats. »

It’s a potent neuroprotective agent too:

« Pretreatment significantly attenuated breakdown of the BBB permeability, brain edema and the CBF disturbances. Damaged and distorted nerve cells were markedly less frequent in treated rats »

Its effects are independent of hormones:

« No effect on plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), thyroid stimulating hormone (TSH), testosterone and other steroid hormones could be observed. These results are discussed in respect to the sexually stimulating effect »

It’s p-chlorophenylalanine (PCPA), a selective and irreversible inhibitor of tryptophan hydroxylase the rate-limiting enzyme in the biosynthesis of serotonin. It doesn’t seem to have been tested in humans yet. The studies are all from the 60s-70s interestingly right before SSRIs were introduced.

It’s just a slightly modified phenylalanine with a Cl. I’m not sure why they wouldn’t instead use a tryptophan derivative but it seems to work.

If low serotonin caused depression then why deleting it causes high libido which is supposedly lost in depression.