u/Gwobbo_

From Wikipedia: "It is the first drug developed that is a highly selective agonist for the D4.

In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.

Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs."

I doubt anyone here has tried this, but it's made me curious about the potential of D4 Agonism for ADHD.

5-Methoxytryptamine from Wikipedia: a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. It has been shown to occur naturally in the pineal gland of the brain. 5-MT is a highly potent and non-selective serotonin receptor agonist and shows serotonergic psychedelic-like effects in animals. However, it is inactive in humans, at least orally, likely due to rapid metabolism by monoamine oxidase (MAO). The levels and effects of 5-MT are dramatically potentiated by monoamine oxidase inhibitors (MAOIs) in animals.

I found a post on reddit describing the experience as "like...contemplative speed. I get an incredible drive to do something worthwhile, to live in the moment."

Also, notably: "There are no distortions but there is a sort of delay when I turn my head." The above Reddit comment is the only anecdote I could find.

"It is an extremely potent serotonin 5-HT2A receptor agonist in vitro, with a EC50Tooltip half-maximal effective concentration of 0.5 nM or 0.7 nM. This was more potent than any other tryptamine evaluated in two large series of compounds. For comparison, 5-MeO-DMT had an EC50 of 3.87 nM (7.7-fold lower) and dimethyltryptamine (DMT) had an EC50 of 38.3 nM (76-fold lower)."

I'm really curious about what would happen if someone combined it with an MAOI. Of course, to my knowledge that'd be dangerous because of potential serotonin syndrome.