Long-term PPI use has documented nutrient effects, here's what to actually ask your doctor to check
If you've been on a PPI for a long stretch, a few nutrients are worth bringing up at your next appointment. PPIs are often the right medication, and knowing these effects helps you ask your doctor more specific questions.
Magnesium. PPIs can reduce magnesium absorption; low magnesium affects muscle tone, sleep, and smooth muscle function (including your LES, somewhat ironically).
B12. Stomach acid is needed to absorb B12 from food; years on a PPI can lead to clinically meaningful depletion.
Iron. Stomach acid converts iron into its absorbable form; long-term suppression can reduce iron absorption.
Calcium. Relevant for bone density, especially for perimenopausal women on long-term PPIs.
Zinc. Needed for mucosal repair, and can be depleted with long-term acid suppression.
Please don't stop a PPI on your own. Stopping suddenly can cause rebound acid, where symptoms come back stronger for a few weeks, and that's why so many people decide they can't come off. If you want to reduce or stop, ask your doctor about tapering slowly.