u/MossKing69

so the left is the 'impurities' and the right is "pure" mescaline sulfate.

BOTH had that black reaction which likely means some mescaline is present however after a few minutes it becomes Bright orange (the mescaline) and the 'impurities' become orange red tone. This likely means amphetamines no?

I'd guess likely TMA aka α-methylmescaline. IDK if recorded before so could be something else... am I doing the reagent test wrong? Indeed both samples start black then go orange or red.

I made this using sodium nitrite and sulfuric acid at 1g to 12ml ratio.

The white crystals that form also didn't dissolve even when crushed.

I can make more reagent and test or film completely. I thought it would remain black solution... anyone else try this reagent on mescaline extract?

Added hcl to fumarate salt from EtOAc precipitation

This is the 'washes' that came off the pretty sulfate crystals I shared a week ago.

so I've come to the conclusion that the 'impurities' from a/b salting regardless of color or solubility is all mescaline. The different solubility of impurities and the insoluble 'pure/clean' mescaline is most likely due to different hydrate form or polymorph of the mescaline salt. I've tested TLC in the past and showed that the impurities is mescaline and now I did a mini a/b using ethyl acetate and fumaric acid on the 'impure washes' and remaining sulfuric acid and recovered 650mg of mescaline fumarate. I estimated around 1.4g sulfate but that was wet material due to sulfuric acid remaining and never 'drying' due to being very hygroscopic. I removed 100mg of a black powder impurity from just doing sodium carbonate freebase. Then did two pulls on the liquid using around 150ml EtOAc. For my references I estimate around 3mg/mL freebase in ethyl acetate. 550mg first pull and 100mg second pull.

Ceilo makes a uniform crystal where as salting with aqueous hcl or sulfuric acid make different forms. I may try gassing hcl in the future to see if it prevents this but not a big fan of the idea. However I've used equal values of mescaline in these different salt forms of mescaline and there seems to be quite a notable subjective difference and most agree that hcl is stronger not only by weight but the experience itself.

Interested in different salt forms to test bioavailability. Many on reddit report lacking experience from citrate and fumarate perhaps since provide dose based on weight and bioavailability is a bigger factor than that? HCL is always reported as strong and my experience has been the same. The only form I felt was as strong or stronger was 'carbonate'

Don't wash your 'dirty' salts or save all the washes. I've had 'losses' as high as 60% to clean the brown hcl salts

from 2.1g total crude to 700mg sulfate. still light brown but doesn't matter.

The swirls was a surprise from the alcohol washed glass normally get needles not swirls

IDK what these are but these only appeared after overnight freezing of sieve dried ethanol washes of the chloroform sulfate extraction. After reaching room temperature it all dissolved and only a smaller amount of white crystals remained which is most likely mescaline sulfate.

Due to color impurities I'll likely need to do a mini-a/b. Isopropanol seems to not dissolve these while ethanol does.

Much darker before first wash. Over acidification as usual. Will save all washes and recrystallize a few times in hot ethanol and hot water.

this is a methanol extraction without any acids. Mescaline in most forms are soluble in methanol... these crystals are likely natural acids and maybe sugars are other products.

Not the best picture but mescaline sulfate is the prettiest crystal form I’ve seen for Mescaline.