u/No-Suggestion-8878

Hi fellow DOR ladies! I am 5W (got pregnant spontaneously with cyclical HRT ~ transdermal estradiol 1mg daily & 100-200mg luteal oral progesterone). Doctor's haven't been able to fully diagnose me as I am somewhere between DOR & POI... Still get regular periods but need HRT to make everything function. I'm curious about those with DOR who got pregnant naturally ~ did you need HRT?

I'm currently on pretty high levels of vaginal progesterone (200mg vaginally 3x/day) (at 200mg total per day my progesterone was 15, which my RE says is too low).

I'm also still on transdermal estradiol (1mg/day) as when I get off of it I get night sweats, heart palpations and insomnia, so my RE said to stay on it a bit longer until placenta takes over, or at least until week 6.

I am reading all these studies about progesterone or estrogen use while pregnant causing autism, gender dysmorphia, birth defects, behavioral challenges etc. Its just so overwhelming as its not like I want to be taking hormones, but my body doesn't make enough naturally for me to carry the pregnancy to term without help. I make SOME, but not enough.

I wanted to know if some of you DOR ladies were on HRT while pregnant, and how your babies came out? Did you need HRT?

Hi fellow POI mamas! I am 5W (got pregnant spontaneously with cyclical HRT ~ transdermal estradiol 1mg daily & 100-200mg luteal oral progesterone). I am worried about how much hormone I'm on and its safety while pregnant. It feels sometimes like we are such an outlier population that even most RE don't really know how to deal with us... like we CAN get pregnant naturally but then we need HRT to sustain the pregnancy...

I'm currently on pretty high levels of vaginal progesterone (200mg vaginally 3x/day) (at 200mg total per day my progesterone was 15 which my RE says is too low).

I'm also still on transdermal estradiol (1mg/day) as when I get off of it I get night sweats, heart palpations and insomnia, so my RE said to stay on it a bit longer until placenta takes over, or at least until week 6.

I am reading all these studies about progesterone or estrogen use while pregnant causing autism, gender dysmorphia, birth defects, behavioral challenges etc. Its just so overwhelming as its not like I want to be taking hormones, but my body doesn't make enough naturally for me to carry the pregnancy to term without help.

I wanted to know if you were on HRT while pregnant how your babies came out?

It can feel so lonely to be POI and pregnant as family & friends are really worried with all the HRT I'm taking, and, as someone who generally doesn't like drugs or want to expose a baby to them, I am worried too! Although also so grateful as they are why I was able to conceive! It can feel really overwhelming as I don't think as a population we are really studied at all (like we are not IVF, we do conceive, but then need a lot of overlapping care), and I don't know if the health of our babies as a population is really studied either. Sometimes I feel defective but I know we are not!

Anyone relate? How was your pregnancy? And how did your babies turn out? Thank you so much.

TW: Sexuality & Gender Identity

I'm 5w pregnant with my first, and have POI so do not create enough hormone on my own and am on HRT (estrogen & progesterone). Since becoming pregnant (spontaneous while on HRT), I've continued 100mg oral progesterone, and then switched to 200mg vaginal progesterone per my OB. My progesterone across week 4 and week 5 blood tests has been consistent around 15. I saw an OB specialist yesterday who diagnosed a hematoma near the embryo and gave me a progesterone IM injection, and asked me to also take 400mg progesterone daily (plus the 50mg IM progesterone), to get my levels up higher.

I tend to want to do everything naturally and Googled what side effects progesterone can have on embryo and the children when they become adults, and found a (flawed) study where it increased the percentage of homosexual and bisexual sexual orientation. It scared the daylights out of me (cue questions of why more studies like this haven't been done, have pharma groups suppressed data, are we guinea pigs, etc).

I was wondering if anyone has experiences with IVF or miscarriage or otherwise needed progesterone for the pregnancy and if that affected your children across their development and puberty?

I know this is a touchy subject and I am not trying to be unkind or unaccepting. And I would feel absolutely terrible if I altered our child's orientation or sense of identity artificially through drugs while they were developing.

Thank you

I have been on 1mg topical daily systemic estradiol & 100mg luteal micronized progesterone for the last couple years following a traumatic injury that caused premature POI, endocrine collapse & menopause symptoms.

I'm receiving mixed info from my Doctors and don't know what to trust. I think cases like mine are very rare and no one seems to know what to do with me. I was told by an RE I had a less than 1% chance of conceiving and that I needed donor eggs, and to get off all hormones, which I refused to do.

I'm 4.5 weeks, with doubling HCG and stable progesterone levels per 2 blood tests.

I did contact that RE (who I've only seen once & didn't feel gave my chart the time of day) and his nurse told me to stay on the 100mg of progesterone and stop the estradiol.

My ND who prescribed the HRT for POI said to switch to 200mg vaginal progesterone suppositories (100mg twice a day) and stop the estradiol.

I booked with an OB (I didn't have one) and she told me to stop everything, but hasn't seen me as a patient yet so doesn't understand my case.

I'm terrified of stopping the estradiol before the placenta takes over since my body doesn't make enough on its own (I'm in low-normal ranges when taking daily 1mg topical cream).

I've read that many IVF and donor egg pregnancies stay on estradiol until the placenta takes over.

If my body doesn't produce enough estrogen on its own, is it truly safe for me to stop taking it before the placenta takes over? Is it dangerous to continue?

I don't want to harm this pregnancy and at the same time I don't feel like any of these doctors are actually reviewing or understand my case. The RE runs a massive clinic and he doesn't really give the time of day to anyone ~ everything is referred through his nurses via messages and they were telling me for months that i needed to stop HRT and that supplements wouldn't make a difference, which I knew was wrong. He runs an IVF business so I think he focuses mostly on that.

My ND is awesome but she doesn't specialize in pregnancy so she doesn't know for sure what to do.

And my new OB I don't see until mid-July, so she told me to stop everything via a receptionist but has never seen my chart.

I just messaged the RE's office and asked to have the Dr there review my chart and case and call me, and also messaged another RE practitioner to see if there's any chance I can get in with them asap.

I'm afraid of stopping the estradiol since I don't make enough naturally (although clearly make some as I did ovulate) but I also don't want to harm the developing fetus. This is super time-sensitive and I am so stressed. Guidance is very much appreciated!