r/TTC_POI

Sorry if this is the wrong group, I’m not sure where would be the right one or if anyone would have any input.

Background info - 34Y female, suspected POI, low AMH and high FSH. Started NHS wales referral in August 2024, due to the time it took to get to the first phone call, we decided to have some private investigations which led to us finding out about my issues. Eventually saw NHS consultant, had Hycosy and both tubes open. Ovaries during scans were either silent or AFC was 3 at most. Periods all over the place. Tried letrozole, first two rounds I ovulated on 2.5mg but then nothing after that. NHS consultant referred us in March 2026 for NHS IVF because I did respond to meds but the referral was declined instantly. Hard pill to swallow and we felt very lost but accepted and moved on.

This morning, I received a phone call from the fertility centre in wales advising someone within gynae has queried why it was refused causing a DR to look into it and whilst it was refused due to low AMH, she said there are other options to try help. I’ve been sent forms to complete, asked to have another AMH blood test and invited to a consultation with my husband in October.

We know we are likely still not eligible for IVF but also grateful just for them being willing to try help us. Just no clue what to expect going forward?

Anyone experienced anything similar?

Sending lots of love to us warriors going through this tough journey xxx

Hey everyone! I’m not sure if this is the right place to post as I haven’t gotten an official POI diagnosis, and I’m considered DOR. My AMH is super low (undetectable) but my FSH can swing from 9 to 60. My REI still won’t say POI because I still get spontaneous cycles that range from 23-35 days, but are unpredictable. I have no other classic menopause symptoms and irregular cycles have been since my late teens / early 20s so I may have been DOR all along.

I’m currently 34 and I’m egg freezing because I’m still single and I want to wait for a partner first. (I’m not open to donor eggs or single parenting at this tine). My doctor said if I was willing to get pregnant now, IUI would be a good option, but my goal is freezing for now, knowing my early menopause risk.

I was initially turned away from an egg freezing clinic at 32 but at 34 I had one amazing doctor who took a chance on me. We had two cancelled cycles because both times I ovulated quickly but we finally managed to retrieve 1 egg at the third attempt and I couldn’t be prouder of my body.

I understand that 1 egg isn’t enough for the bank so my doctor said a realistic target is 4-5 at my age. I’m open to doing more cycles. My issue is that my AFC usually hovers from 4-6 at the beginning of the cycle but two follicles hog up the stims but the end. Is there a way to evenly distribute the growth so I can potentially retrieve more in one cycle? I have my follow up appointment in a couple of days so I want to come prepared with questions for him. Otherwise I’ve budgeted 4 cycles for 4 eggs, knowing it’s the best I can get. I’m just hoping I could somehow get two eggs per cycle.

The protocol we did was estrase priming with letrozole after and stims with double orgalutran to prevent ovulation. And triggering at 17 mm. A natural start did manage to recruit more follicles but I lost the cycle too quickly to ovulation.

Hi everyone,

Hoping to find someone here who has experienced the same and can give me some advice, because my head is spinning. Actually cried over this a lot today.

My very close friend who supported me through thick and thin the last years and I had conversation about my fertility journey yesterday in which she all of a sudden shared with me she would never feel comfortable donating her egg to anyone.

Now, this is all hypothetical because we are both 40 and I was never going to ask her for anything or expecting anything . But it really felt like a punch in the gut to hear her say “it would feel like giving away my own child” while she knows I am in the process of deciding if egg donation is the right way for me. I’ve never heard her say anything negative about gamete donation before. I thought she was on board and supporting my journey. She even said a few years ago she would’ve become a single mom if she had not found her boyfriend.

I’m very torn between the “it’s her opinion and that’s fine” and “is she rejecting my life choices?”. Or is it something she wouldn’t do but she’s ok with people donating to banks?

I thought she was supportive of my choices, but now I don’t know. Has anyone been in this situation and what did you do? I’m so torn between accepting her personal beliefs and it not being any judgement over mine, but it feels like she’s judging my decisions. But I want to decide if I should respond to this or not, or just let it be. Any advice?

I used DE with success, now about 2 months postpartum and finally got someone to prescribe estrogen (weekly patch) and progesterone. They said that though hormones pass through the breastmilk, it is thought to be safe.. but I have not seen studies talking about safety while taking POI doses of hormones. Looking for reassurance this won't hurt the baby! Thank you!

In June , my AMH and AFC were respectively 0.8 and 5
My doctor told us to start trying. however since me and my partner weren’t mentally prepared we hadnt started actively trying. Though i started folic acid, d3 , b12, ovares A and KQ fert tablets.
Cut short, I visited doctor today, my amh is 0.99 and afc is 4. The doctor told this is the last cycle we can try naturally or else we go for IVF. I am confused. My age is 28 and husband is 30.None of us is obese , husband SA was 47 mil.
I dont want to jump into ivf. Have this gut feeling will concieve this month

Hi all. I am wondering about my low estrogen, how often we should be testing + what day of cycle to draw, and why it wasn't caught? I am still cycling but on HRT. I began having more extreme symptoms of POI in 2024 (had been since 2018 at age 32 but wasn't given HRT until 2024)

My labs were always drawn 4-6 days post ovulation. (LUTEAL)

2024: 87 pg/mL (on 0.025mg weekly patch)

2024 (a week after bumping up to 0.0375mg biweekly estradiol patch): 146 pg/mL

2025: 94pg/mL (a year on the 0.0375mg biweekly patch as it stopped working; I hadn't ovulated this month either)

2026: 56.7 pg/mL (on the oral pill at 0.75mg daily about a year)

At this point and after ME doing so much research into POI and cycling POI, my Dr. FINALLY decided I needed a physiologic replacement dose and bumped me up to 1mg topical estradiol gel and now we are exploring 1.5mg topical gel. I'm in the water daily so the patch was not consistent for me.

I'm wondering when the proper time is to draw blood when you're still cycling (on HRT)?

Also ~ WHY with low levels across YEARS AND having POI, why wasn't I given the proper dose??

I'm now having to get a DEXA scan and am really worried about osteoperosis and osteopenia. I'm 40, and have had low estrogen since age 32. What do I do?

I'm so upset. We are also TTC and I did get pregnant a few months ago after being put on a higher estrogen dose, but had a miscarriage.