New phase 4 trial recruiting to see if semaglutide reduces morning stiffness in people with osteoarthritis
I have osteoarthritis in my knees, and I've noticed that my morning stiffness improved within weeks of starting Zepbound, before I lost significant weight. Now there's an official phase 4 trial (NCT06942051, just posted) looking specifically at whether semaglutide 2.4 mg reduces morning stiffness duration and severity in knee OA patients with obesity. The primary endpoint is change in WOMAC stiffness subscore at 24 weeks. If you're struggling with creaky mornings, this might be something to keep an eye on.